Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SLC9A3 (solute carrier family 9 member A3)

Identity

Alias_namesNHE3
solute carrier family 9 (sodium/hydrogen exchanger), isoform 3
solute carrier family 9 (sodium/hydrogen exchanger), member 3
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Other aliasDIAR8
NHE-3
HGNC (Hugo) SLC9A3
LocusID (NCBI) 6550
Atlas_Id 45845
Location 5p15.33  [Link to chromosome band 5p15]
Location_base_pair Starts at 471986 and ends at 524434 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC9A3   11073
Cards
Entrez_Gene (NCBI)SLC9A3  6550  solute carrier family 9 member A3
AliasesDIAR8; NHE-3; NHE3
GeneCards (Weizmann)SLC9A3
Ensembl hg19 (Hinxton)ENSG00000066230 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000066230 [Gene_View]  chr5:471986-524434 [Contig_View]  SLC9A3 [Vega]
ICGC DataPortalENSG00000066230
TCGA cBioPortalSLC9A3
AceView (NCBI)SLC9A3
Genatlas (Paris)SLC9A3
WikiGenes6550
SOURCE (Princeton)SLC9A3
Genetics Home Reference (NIH)SLC9A3
Genomic and cartography
GoldenPath hg38 (UCSC)SLC9A3  -     chr5:471986-524434 -  5p15.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC9A3  -     5p15.33   [Description]    (hg19-Feb_2009)
EnsemblSLC9A3 - 5p15.33 [CytoView hg19]  SLC9A3 - 5p15.33 [CytoView hg38]
Mapping of homologs : NCBISLC9A3 [Mapview hg19]  SLC9A3 [Mapview hg38]
OMIM182307   616868   
Gene and transcription
Genbank (Entrez)BC011555 BC101669 BC101671 BC143328 BP270851
RefSeq transcript (Entrez)NM_001284351 NM_004174
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_046804 NT_187550
Consensus coding sequences : CCDS (NCBI)SLC9A3
Cluster EST : UnigeneHs.658120 [ NCBI ]
CGAP (NCI)Hs.658120
Alternative Splicing GalleryENSG00000066230
Gene ExpressionSLC9A3 [ NCBI-GEO ]   SLC9A3 [ EBI - ARRAY_EXPRESS ]   SLC9A3 [ SEEK ]   SLC9A3 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC9A3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6550
GTEX Portal (Tissue expression)SLC9A3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48764   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48764  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48764
Splice isoforms : SwissVarP48764
PhosPhoSitePlusP48764
Domains : Interpro (EBI)Cation/H_exchanger    Cation/H_exchanger_CPA1    Na/H_exchanger_3/5    NaH_exchanger   
Domain families : Pfam (Sanger)Na_H_Exchanger (PF00999)   
Domain families : Pfam (NCBI)pfam00999   
Conserved Domain (NCBI)SLC9A3
DMDM Disease mutations6550
Blocks (Seattle)SLC9A3
SuperfamilyP48764
Human Protein AtlasENSG00000066230
Peptide AtlasP48764
HPRD01660
IPIIPI00011184   IPI00967021   
Protein Interaction databases
DIP (DOE-UCLA)P48764
IntAct (EBI)P48764
FunCoupENSG00000066230
BioGRIDSLC9A3
STRING (EMBL)SLC9A3
ZODIACSLC9A3
Ontologies - Pathways
QuickGOP48764
Ontology : AmiGOprotein binding  plasma membrane  plasma membrane  plasma membrane  brush border  ion transport  cell surface  sodium:proton antiporter activity  sodium:proton antiporter activity  sodium:proton antiporter activity  potassium:proton antiporter activity  integral component of membrane  apical plasma membrane  apical plasma membrane  PDZ domain binding  brush border membrane  brush border membrane  regulation of intracellular pH  extracellular exosome  potassium ion transmembrane transport  sodium ion import across plasma membrane  hydrogen ion transmembrane transport  
Ontology : EGO-EBIprotein binding  plasma membrane  plasma membrane  plasma membrane  brush border  ion transport  cell surface  sodium:proton antiporter activity  sodium:proton antiporter activity  sodium:proton antiporter activity  potassium:proton antiporter activity  integral component of membrane  apical plasma membrane  apical plasma membrane  PDZ domain binding  brush border membrane  brush border membrane  regulation of intracellular pH  extracellular exosome  potassium ion transmembrane transport  sodium ion import across plasma membrane  hydrogen ion transmembrane transport  
Pathways : KEGGProximal tubule bicarbonate reclamation    Protein digestion and absorption    Bile secretion    Mineral absorption   
NDEx NetworkSLC9A3
Atlas of Cancer Signalling NetworkSLC9A3
Wikipedia pathwaysSLC9A3
Orthology - Evolution
OrthoDB6550
GeneTree (enSembl)ENSG00000066230
Phylogenetic Trees/Animal Genes : TreeFamSLC9A3
HOVERGENP48764
HOGENOMP48764
Homologs : HomoloGeneSLC9A3
Homology/Alignments : Family Browser (UCSC)SLC9A3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC9A3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC9A3
dbVarSLC9A3
ClinVarSLC9A3
1000_GenomesSLC9A3 
Exome Variant ServerSLC9A3
ExAC (Exome Aggregation Consortium)SLC9A3 (select the gene name)
Genetic variants : HAPMAP6550
Genomic Variants (DGV)SLC9A3 [DGVbeta]
DECIPHERSLC9A3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC9A3 
Mutations
ICGC Data PortalSLC9A3 
TCGA Data PortalSLC9A3 
Broad Tumor PortalSLC9A3
OASIS PortalSLC9A3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC9A3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC9A3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC9A3
DgiDB (Drug Gene Interaction Database)SLC9A3
DoCM (Curated mutations)SLC9A3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC9A3 (select a term)
intoGenSLC9A3
Cancer3DSLC9A3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182307    616868   
Orphanet14984   
MedgenSLC9A3
Genetic Testing Registry SLC9A3
NextProtP48764 [Medical]
TSGene6550
GENETestsSLC9A3
Target ValidationSLC9A3
Huge Navigator SLC9A3 [HugePedia]
snp3D : Map Gene to Disease6550
BioCentury BCIQSLC9A3
ClinGenSLC9A3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6550
Chemical/Pharm GKB GenePA316
Clinical trialSLC9A3
Miscellaneous
canSAR (ICR)SLC9A3 (select the gene name)
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC9A3
EVEXSLC9A3
GoPubMedSLC9A3
iHOPSLC9A3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:07:49 CEST 2017

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