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SLC9A4 (solute carrier family 9 member A4)

Identity

Alias (NCBI)NHE4
HGNC (Hugo) SLC9A4
HGNC Alias symbNHE4
HGNC Previous namesolute carrier family 9 (sodium/hydrogen exchanger), isoform 4
 solute carrier family 9 (sodium/hydrogen exchanger), member 4
 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
LocusID (NCBI) 389015
Atlas_Id 73495
Location 2q12.1  [Link to chromosome band 2q12]
Location_base_pair Starts at 102473226 and ends at 102533972 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SLC9A4   11077
Cards
Entrez_Gene (NCBI)SLC9A4    solute carrier family 9 member A4
AliasesNHE4
GeneCards (Weizmann)SLC9A4
Ensembl hg19 (Hinxton)ENSG00000180251 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180251 [Gene_View]  ENSG00000180251 [Sequence]  chr2:102473226-102533972 [Contig_View]  SLC9A4 [Vega]
ICGC DataPortalENSG00000180251
TCGA cBioPortalSLC9A4
AceView (NCBI)SLC9A4
Genatlas (Paris)SLC9A4
SOURCE (Princeton)SLC9A4
Genetics Home Reference (NIH)SLC9A4
Genomic and cartography
GoldenPath hg38 (UCSC)SLC9A4  -     chr2:102473226-102533972 +  2q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC9A4  -     2q12.1   [Description]    (hg19-Feb_2009)
GoldenPathSLC9A4 - 2q12.1 [CytoView hg19]  SLC9A4 - 2q12.1 [CytoView hg38]
ImmunoBaseENSG00000180251
Genome Data Viewer NCBISLC9A4 [Mapview hg19]  
OMIM600531   
Gene and transcription
Genbank (Entrez)AL833048 CR627411 DA442134
RefSeq transcript (Entrez)NM_001011552
Consensus coding sequences : CCDS (NCBI)SLC9A4
Gene ExpressionSLC9A4 [ NCBI-GEO ]   SLC9A4 [ EBI - ARRAY_EXPRESS ]   SLC9A4 [ SEEK ]   SLC9A4 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC9A4 [ Firebrowse - Broad ]
GenevisibleExpression of SLC9A4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)389015
GTEX Portal (Tissue expression)SLC9A4
Human Protein AtlasENSG00000180251-SLC9A4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6AI14   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6AI14  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6AI14
PhosPhoSitePlusQ6AI14
Domains : Interpro (EBI)Cation/H_exchanger    Cation/H_exchanger_CPA1    Na/H_exchanger_2    NaH_exchanger    NHE_CaM-bd    NHX4   
Domain families : Pfam (Sanger)Na_H_Exchanger (PF00999)    NEXCaM_BD (PF16644)   
Domain families : Pfam (NCBI)pfam00999    pfam16644   
Conserved Domain (NCBI)SLC9A4
SuperfamilyQ6AI14
AlphaFold pdb e-kbQ6AI14   
Human Protein Atlas [tissue]ENSG00000180251-SLC9A4 [tissue]
HPRD15973
Protein Interaction databases
DIP (DOE-UCLA)Q6AI14
IntAct (EBI)Q6AI14
BioGRIDSLC9A4
STRING (EMBL)SLC9A4
ZODIACSLC9A4
Ontologies - Pathways
QuickGOQ6AI14
Ontology : AmiGOgastric acid secretion  epithelial cell development  vacuolar membrane  plasma membrane  plasma membrane  ion transport  response to salt stress  sodium:proton antiporter activity  potassium:proton antiporter activity  integral component of membrane  basolateral plasma membrane  apical plasma membrane  regulation of intracellular pH  potassium ion homeostasis  potassium ion transmembrane transport  anion transmembrane transport  sodium ion import across plasma membrane  proton transmembrane transport  
Ontology : EGO-EBIgastric acid secretion  epithelial cell development  vacuolar membrane  plasma membrane  plasma membrane  ion transport  response to salt stress  sodium:proton antiporter activity  potassium:proton antiporter activity  integral component of membrane  basolateral plasma membrane  apical plasma membrane  regulation of intracellular pH  potassium ion homeostasis  potassium ion transmembrane transport  anion transmembrane transport  sodium ion import across plasma membrane  proton transmembrane transport  
NDEx NetworkSLC9A4
Atlas of Cancer Signalling NetworkSLC9A4
Wikipedia pathwaysSLC9A4
Orthology - Evolution
OrthoDB389015
GeneTree (enSembl)ENSG00000180251
Phylogenetic Trees/Animal Genes : TreeFamSLC9A4
Homologs : HomoloGeneSLC9A4
Homology/Alignments : Family Browser (UCSC)SLC9A4
Gene fusions - Rearrangements
Fusion : QuiverSLC9A4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC9A4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC9A4
dbVarSLC9A4
ClinVarSLC9A4
MonarchSLC9A4
1000_GenomesSLC9A4 
Exome Variant ServerSLC9A4
GNOMAD BrowserENSG00000180251
Varsome BrowserSLC9A4
ACMGSLC9A4 variants
VarityQ6AI14
Genomic Variants (DGV)SLC9A4 [DGVbeta]
DECIPHERSLC9A4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC9A4 
Mutations
ICGC Data PortalSLC9A4 
TCGA Data PortalSLC9A4 
Broad Tumor PortalSLC9A4
OASIS PortalSLC9A4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC9A4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSLC9A4
Mutations and Diseases : HGMDSLC9A4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSLC9A4
DgiDB (Drug Gene Interaction Database)SLC9A4
DoCM (Curated mutations)SLC9A4
CIViC (Clinical Interpretations of Variants in Cancer)SLC9A4
Cancer3DSLC9A4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600531   
Orphanet
DisGeNETSLC9A4
MedgenSLC9A4
Genetic Testing Registry SLC9A4
NextProtQ6AI14 [Medical]
GENETestsSLC9A4
Target ValidationSLC9A4
Huge Navigator SLC9A4 [HugePedia]
ClinGenSLC9A4
Clinical trials, drugs, therapy
MyCancerGenomeSLC9A4
Protein Interactions : CTDSLC9A4
Pharm GKB GenePA35933
PharosQ6AI14
Clinical trialSLC9A4
Miscellaneous
canSAR (ICR)SLC9A4
HarmonizomeSLC9A4
DataMed IndexSLC9A4
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSLC9A4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:21:14 CEST 2021

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