Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SLC9A4 (solute carrier family 9 member A4)

Identity

Alias_namessolute carrier family 9 (sodium/hydrogen exchanger), isoform 4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
Alias_symbol (synonym)NHE4
Other alias
HGNC (Hugo) SLC9A4
LocusID (NCBI) 389015
Atlas_Id 73495
Location 2q12.1  [Link to chromosome band 2q12]
Location_base_pair Starts at 102473303 and ends at 102533972 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC9A4   11077
Cards
Entrez_Gene (NCBI)SLC9A4  389015  solute carrier family 9 member A4
AliasesNHE4
GeneCards (Weizmann)SLC9A4
Ensembl hg19 (Hinxton)ENSG00000180251 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180251 [Gene_View]  chr2:102473303-102533972 [Contig_View]  SLC9A4 [Vega]
ICGC DataPortalENSG00000180251
TCGA cBioPortalSLC9A4
AceView (NCBI)SLC9A4
Genatlas (Paris)SLC9A4
WikiGenes389015
SOURCE (Princeton)SLC9A4
Genetics Home Reference (NIH)SLC9A4
Genomic and cartography
GoldenPath hg38 (UCSC)SLC9A4  -     chr2:102473303-102533972 +  2q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC9A4  -     2q12.1   [Description]    (hg19-Feb_2009)
EnsemblSLC9A4 - 2q12.1 [CytoView hg19]  SLC9A4 - 2q12.1 [CytoView hg38]
Mapping of homologs : NCBISLC9A4 [Mapview hg19]  SLC9A4 [Mapview hg38]
OMIM600531   
Gene and transcription
Genbank (Entrez)AL833048 BC160158 CR627411 DA442134
RefSeq transcript (Entrez)NM_001011552
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC9A4
Cluster EST : UnigeneHs.447686 [ NCBI ]
CGAP (NCI)Hs.447686
Alternative Splicing GalleryENSG00000180251
Gene ExpressionSLC9A4 [ NCBI-GEO ]   SLC9A4 [ EBI - ARRAY_EXPRESS ]   SLC9A4 [ SEEK ]   SLC9A4 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC9A4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)389015
GTEX Portal (Tissue expression)SLC9A4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6AI14   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6AI14  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6AI14
Splice isoforms : SwissVarQ6AI14
PhosPhoSitePlusQ6AI14
Domains : Interpro (EBI)Cation/H_exchanger    Cation/H_exchanger_CPA1    Na/H_exchanger_2    NaH_exchanger    NHE_CaM-bd   
Domain families : Pfam (Sanger)Na_H_Exchanger (PF00999)    NEXCaM_BD (PF16644)   
Domain families : Pfam (NCBI)pfam00999    pfam16644   
Conserved Domain (NCBI)SLC9A4
DMDM Disease mutations389015
Blocks (Seattle)SLC9A4
SuperfamilyQ6AI14
Human Protein AtlasENSG00000180251
Peptide AtlasQ6AI14
HPRD15973
IPIIPI00465002   
Protein Interaction databases
DIP (DOE-UCLA)Q6AI14
IntAct (EBI)Q6AI14
FunCoupENSG00000180251
BioGRIDSLC9A4
STRING (EMBL)SLC9A4
ZODIACSLC9A4
Ontologies - Pathways
QuickGOQ6AI14
Ontology : AmiGOgastric acid secretion  epithelial cell development  plasma membrane  plasma membrane  ion transport  sodium:proton antiporter activity  sodium:proton antiporter activity  potassium:proton antiporter activity  integral component of membrane  basolateral plasma membrane  apical plasma membrane  regulation of intracellular pH  potassium ion transmembrane transport  sodium ion import across plasma membrane  hydrogen ion transmembrane transport  
Ontology : EGO-EBIgastric acid secretion  epithelial cell development  plasma membrane  plasma membrane  ion transport  sodium:proton antiporter activity  sodium:proton antiporter activity  potassium:proton antiporter activity  integral component of membrane  basolateral plasma membrane  apical plasma membrane  regulation of intracellular pH  potassium ion transmembrane transport  sodium ion import across plasma membrane  hydrogen ion transmembrane transport  
Pathways : KEGGGastric acid secretion   
NDEx NetworkSLC9A4
Atlas of Cancer Signalling NetworkSLC9A4
Wikipedia pathwaysSLC9A4
Orthology - Evolution
OrthoDB389015
GeneTree (enSembl)ENSG00000180251
Phylogenetic Trees/Animal Genes : TreeFamSLC9A4
HOVERGENQ6AI14
HOGENOMQ6AI14
Homologs : HomoloGeneSLC9A4
Homology/Alignments : Family Browser (UCSC)SLC9A4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC9A4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC9A4
dbVarSLC9A4
ClinVarSLC9A4
1000_GenomesSLC9A4 
Exome Variant ServerSLC9A4
ExAC (Exome Aggregation Consortium)SLC9A4 (select the gene name)
Genetic variants : HAPMAP389015
Genomic Variants (DGV)SLC9A4 [DGVbeta]
DECIPHERSLC9A4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC9A4 
Mutations
ICGC Data PortalSLC9A4 
TCGA Data PortalSLC9A4 
Broad Tumor PortalSLC9A4
OASIS PortalSLC9A4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC9A4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC9A4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC9A4
DgiDB (Drug Gene Interaction Database)SLC9A4
DoCM (Curated mutations)SLC9A4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC9A4 (select a term)
intoGenSLC9A4
Cancer3DSLC9A4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600531   
Orphanet
MedgenSLC9A4
Genetic Testing Registry SLC9A4
NextProtQ6AI14 [Medical]
TSGene389015
GENETestsSLC9A4
Target ValidationSLC9A4
Huge Navigator SLC9A4 [HugePedia]
snp3D : Map Gene to Disease389015
BioCentury BCIQSLC9A4
ClinGenSLC9A4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD389015
Chemical/Pharm GKB GenePA35933
Clinical trialSLC9A4
Miscellaneous
canSAR (ICR)SLC9A4 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC9A4
EVEXSLC9A4
GoPubMedSLC9A4
iHOPSLC9A4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:38:20 CEST 2017

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