SLC9A5 (solute carrier family 9 member A5)

2014-11-01 Affiliation

Identity

HGNC

SLC9A5

LOCATION

16q22.1

LOCUSID

6553

ALIAS

NHE5

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6553
MIM: 600477
HGNC: 11078
Ensembl: ENSG00000135740

Variants:

dbSNP: 6553
ClinVar: 6553
TCGA: ENSG00000135740
COSMIC: SLC9A5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135740	ENST00000299798	Q14940
ENSG00000135740	ENST00000564812	H3BNY2
ENSG00000135740	ENST00000566345	J3KSE2
ENSG00000135740	ENST00000566626	J3KSB3
ENSG00000135740	ENST00000567247	J3QRV1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME	R-HSA-425393
Sodium/Proton exchangers	REACTOME	R-HSA-425986

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA27745	ELF2	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
21551074	2011	Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na⁺/H⁺ exchanger NHE5.	23
15699339	2005	beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform.	17
12205089	2002	Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton.	14
16920332	2007	RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity.	13
19276089	2009	Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5.	10
21296876	2011	CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis.	6
24936055	2014	Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surface.	5
31595389	2019	NHE5 regulates growth factor signaling, integrin trafficking, and degradation in glioma cells.	2

Citation

Dessen P

SLC9A5 (solute carrier family 9 member A5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73496/slc9a5