SLC9A8 (solute carrier family 9 member A8)

2009-05-01  

Identity

HGNC
LOCATION
20q13.13
LOCUSID
ALIAS
NHE-8,NHE8
FUSION GENES

Other Information

Locus ID:

NCBI: 23315
MIM: 612730
HGNC: 20728
Ensembl: ENSG00000197818

Variants:

dbSNP: 23315
ClinVar: 23315
TCGA: ENSG00000197818
COSMIC: SLC9A8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197818ENST00000361573Q9Y2E8
ENSG00000197818ENST00000417961Q9Y2E8

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium/Proton exchangersREACTOMER-HSA-425986

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
211716502011Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions.34
182094772008Gastrointestinal distribution and kinetic characterization of the sodium-hydrogen exchanger isoform 8 (NHE8).30
191095232009Tumor necrosis factor-{alpha} downregulates intestinal NHE8 expression by reducing basal promoter activity.19
207199632010The sodium/proton exchanger NHE8 regulates late endosomal morphology and function.17
178814262008Familial pure proximal renal tubular acidosis--a clinical and genetic study.12
203752732010Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription.11
216665032011Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea.5
265647202016Intestinal NHE8 is highly expressed in goblet cells and its expression is subject to TNF-α regulation.5
284768882017Loss of the Na+/H+ exchanger NHE8 causes male infertility in mice by disrupting acrosome formation.3

Citation

Dessen P

SLC9A8 (solute carrier family 9 member A8)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50908/slc9a8