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SLC9A8 (solute carrier family 9 member A8)

Identity

Alias_namessolute carrier family 9 (sodium/hydrogen exchanger), isoform 8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
Alias_symbol (synonym)KIAA0939
NHE8
Other aliasNHE-8
HGNC (Hugo) SLC9A8
LocusID (NCBI) 23315
Atlas_Id 50908
Location 20q13.13  [Link to chromosome band 20q13]
Location_base_pair Starts at 49812713 and ends at 49892242 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PC (11q13.2) / SLC9A8 (20q13.13)PTPN1 (20q13.13) / SLC9A8 (20q13.13)SLC9A8 (20q13.13) / CCDC64B (16p13.3)
SLC9A8 (20q13.13) / RAE1 (20q13.31)SNAI1 (20q13.13) / SLC9A8 (20q13.13)ZC3H7B (22q13.2) / SLC9A8 (20q13.13)
ZFP28 (19q13.43) / SLC9A8 (20q13.13)PTPN1 20q13.13 / SLC9A8 20q13.13SLC9A8 20q13.13 / CCDC64B 16p13.3
SLC9A8 20q13.13 / RAE1 20q13.31SNAI1 20q13.13 / SLC9A8 20q13.13ZC3H7B 22q13.2 / SLC9A8 20q13.13
ZFP28 19q13.43 / SLC9A8 20q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC9A8   20728
Cards
Entrez_Gene (NCBI)SLC9A8  23315  solute carrier family 9 member A8
AliasesNHE-8; NHE8
GeneCards (Weizmann)SLC9A8
Ensembl hg19 (Hinxton)ENSG00000197818 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197818 [Gene_View]  chr20:49812713-49892242 [Contig_View]  SLC9A8 [Vega]
ICGC DataPortalENSG00000197818
TCGA cBioPortalSLC9A8
AceView (NCBI)SLC9A8
Genatlas (Paris)SLC9A8
WikiGenes23315
SOURCE (Princeton)SLC9A8
Genetics Home Reference (NIH)SLC9A8
Genomic and cartography
GoldenPath hg38 (UCSC)SLC9A8  -     chr20:49812713-49892242 +  20q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC9A8  -     20q13.13   [Description]    (hg19-Feb_2009)
EnsemblSLC9A8 - 20q13.13 [CytoView hg19]  SLC9A8 - 20q13.13 [CytoView hg38]
Mapping of homologs : NCBISLC9A8 [Mapview hg19]  SLC9A8 [Mapview hg38]
OMIM612730   
Gene and transcription
Genbank (Entrez)AB023156 AK124491 AK131001 AK295665 AK295803
RefSeq transcript (Entrez)NM_001260491 NM_015266
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC9A8
Cluster EST : UnigeneHs.444202 [ NCBI ]
CGAP (NCI)Hs.444202
Alternative Splicing GalleryENSG00000197818
Gene ExpressionSLC9A8 [ NCBI-GEO ]   SLC9A8 [ EBI - ARRAY_EXPRESS ]   SLC9A8 [ SEEK ]   SLC9A8 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC9A8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23315
GTEX Portal (Tissue expression)SLC9A8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2E8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2E8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2E8
Splice isoforms : SwissVarQ9Y2E8
PhosPhoSitePlusQ9Y2E8
Domains : Interpro (EBI)Cation/H_exchanger    Cation/H_exchanger_CPA1    Na/H_exchanger_8    NaH_exchanger   
Domain families : Pfam (Sanger)Na_H_Exchanger (PF00999)   
Domain families : Pfam (NCBI)pfam00999   
Conserved Domain (NCBI)SLC9A8
DMDM Disease mutations23315
Blocks (Seattle)SLC9A8
SuperfamilyQ9Y2E8
Human Protein AtlasENSG00000197818
Peptide AtlasQ9Y2E8
HPRD18062
IPIIPI00943142   IPI00183933   IPI01013242   IPI01015766   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2E8
IntAct (EBI)Q9Y2E8
FunCoupENSG00000197818
BioGRIDSLC9A8
STRING (EMBL)SLC9A8
ZODIACSLC9A8
Ontologies - Pathways
QuickGOQ9Y2E8
Ontology : AmiGOGolgi membrane  Golgi apparatus  plasma membrane  ion transport  sodium:proton antiporter activity  sodium:proton antiporter activity  potassium:proton antiporter activity  integral component of membrane  regulation of intracellular pH  potassium ion transmembrane transport  sodium ion import across plasma membrane  hydrogen ion transmembrane transport  
Ontology : EGO-EBIGolgi membrane  Golgi apparatus  plasma membrane  ion transport  sodium:proton antiporter activity  sodium:proton antiporter activity  potassium:proton antiporter activity  integral component of membrane  regulation of intracellular pH  potassium ion transmembrane transport  sodium ion import across plasma membrane  hydrogen ion transmembrane transport  
NDEx NetworkSLC9A8
Atlas of Cancer Signalling NetworkSLC9A8
Wikipedia pathwaysSLC9A8
Orthology - Evolution
OrthoDB23315
GeneTree (enSembl)ENSG00000197818
Phylogenetic Trees/Animal Genes : TreeFamSLC9A8
HOVERGENQ9Y2E8
HOGENOMQ9Y2E8
Homologs : HomoloGeneSLC9A8
Homology/Alignments : Family Browser (UCSC)SLC9A8
Gene fusions - Rearrangements
Fusion : MitelmanPTPN1/SLC9A8 [20q13.13/20q13.13]  [t(20;20)(q13;q13)]  
Fusion : MitelmanSLC9A8/CCDC64B [20q13.13/16p13.3]  [t(16;20)(p13;q13)]  
Fusion : MitelmanSLC9A8/RAE1 [20q13.13/20q13.31]  [t(20;20)(q13;q13)]  
Fusion : MitelmanSNAI1/SLC9A8 [20q13.13/20q13.13]  [t(20;20)(q13;q13)]  
Fusion : MitelmanZC3H7B/SLC9A8 [22q13.2/20q13.13]  [t(20;22)(q13;q13)]  
Fusion : MitelmanZFP28/SLC9A8 [19q13.43/20q13.13]  [t(19;20)(q13;q13)]  
Fusion: TCGAPTPN1 20q13.13 SLC9A8 20q13.13 BRCA
Fusion: TCGASLC9A8 20q13.13 CCDC64B 16p13.3 BRCA
Fusion: TCGASLC9A8 20q13.13 RAE1 20q13.31 BRCA
Fusion: TCGASNAI1 20q13.13 SLC9A8 20q13.13 BRCA
Fusion: TCGAZC3H7B 22q13.2 SLC9A8 20q13.13 OV
Fusion: TCGAZFP28 19q13.43 SLC9A8 20q13.13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC9A8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC9A8
dbVarSLC9A8
ClinVarSLC9A8
1000_GenomesSLC9A8 
Exome Variant ServerSLC9A8
ExAC (Exome Aggregation Consortium)SLC9A8 (select the gene name)
Genetic variants : HAPMAP23315
Genomic Variants (DGV)SLC9A8 [DGVbeta]
DECIPHERSLC9A8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC9A8 
Mutations
ICGC Data PortalSLC9A8 
TCGA Data PortalSLC9A8 
Broad Tumor PortalSLC9A8
OASIS PortalSLC9A8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC9A8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC9A8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC9A8
DgiDB (Drug Gene Interaction Database)SLC9A8
DoCM (Curated mutations)SLC9A8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC9A8 (select a term)
intoGenSLC9A8
Cancer3DSLC9A8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612730   
Orphanet
MedgenSLC9A8
Genetic Testing Registry SLC9A8
NextProtQ9Y2E8 [Medical]
TSGene23315
GENETestsSLC9A8
Target ValidationSLC9A8
Huge Navigator SLC9A8 [HugePedia]
snp3D : Map Gene to Disease23315
BioCentury BCIQSLC9A8
ClinGenSLC9A8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23315
Chemical/Pharm GKB GenePA134924114
Clinical trialSLC9A8
Miscellaneous
canSAR (ICR)SLC9A8 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC9A8
EVEXSLC9A8
GoPubMedSLC9A8
iHOPSLC9A8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:15:00 CEST 2017

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