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SLC9A8 (solute carrier family 9 member A8)

Identity

Alias (NCBI)NHE-8
NHE8
HGNC (Hugo) SLC9A8
HGNC Alias symbKIAA0939
NHE8
HGNC Previous namesolute carrier family 9 (sodium/hydrogen exchanger), isoform 8
 solute carrier family 9 (sodium/hydrogen exchanger), member 8
 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
LocusID (NCBI) 23315
Atlas_Id 50908
Location 20q13.13  [Link to chromosome band 20q13]
Location_base_pair Starts at 49812828 and ends at 49892242 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PC (11q13.2) / SLC9A8 (20q13.13)PTPN1 (20q13.13) / SLC9A8 (20q13.13)SLC9A8 (20q13.13) / CCDC64B (16p13.3)
SLC9A8 (20q13.13) / RAE1 (20q13.31)SNAI1 (20q13.13) / SLC9A8 (20q13.13)ZC3H7B (22q13.2) / SLC9A8 (20q13.13)
ZFP28 (19q13.43) / SLC9A8 (20q13.13)PTPN1 20q13.13 / SLC9A8 20q13.13SLC9A8 20q13.13 / CCDC64B 16p13.3
SLC9A8 20q13.13 / RAE1 20q13.31SNAI1 20q13.13 / SLC9A8 20q13.13ZC3H7B 22q13.2 / SLC9A8 20q13.13
ZFP28 19q13.43 / SLC9A8 20q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SLC9A8   20728
Cards
Entrez_Gene (NCBI)SLC9A8    solute carrier family 9 member A8
AliasesNHE-8; NHE8
GeneCards (Weizmann)SLC9A8
Ensembl hg19 (Hinxton)ENSG00000197818 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197818 [Gene_View]  ENSG00000197818 [Sequence]  chr20:49812828-49892242 [Contig_View]  SLC9A8 [Vega]
ICGC DataPortalENSG00000197818
TCGA cBioPortalSLC9A8
AceView (NCBI)SLC9A8
Genatlas (Paris)SLC9A8
SOURCE (Princeton)SLC9A8
Genetics Home Reference (NIH)SLC9A8
Genomic and cartography
GoldenPath hg38 (UCSC)SLC9A8  -     chr20:49812828-49892242 +  20q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC9A8  -     20q13.13   [Description]    (hg19-Feb_2009)
GoldenPathSLC9A8 - 20q13.13 [CytoView hg19]  SLC9A8 - 20q13.13 [CytoView hg38]
ImmunoBaseENSG00000197818
Genome Data Viewer NCBISLC9A8 [Mapview hg19]  
OMIM612730   
Gene and transcription
Genbank (Entrez)AB023156 AK124491 AK131001 AK295665 AK295803
RefSeq transcript (Entrez)NM_001260491 NM_015266
Consensus coding sequences : CCDS (NCBI)SLC9A8
Gene ExpressionSLC9A8 [ NCBI-GEO ]   SLC9A8 [ EBI - ARRAY_EXPRESS ]   SLC9A8 [ SEEK ]   SLC9A8 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC9A8 [ Firebrowse - Broad ]
GenevisibleExpression of SLC9A8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23315
GTEX Portal (Tissue expression)SLC9A8
Human Protein AtlasENSG00000197818-SLC9A8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2E8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2E8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2E8
PhosPhoSitePlusQ9Y2E8
Domains : Interpro (EBI)Cation/H_exchanger    Cation/H_exchanger_CPA1    NaH_exchanger   
Domain families : Pfam (Sanger)Na_H_Exchanger (PF00999)   
Domain families : Pfam (NCBI)pfam00999   
Conserved Domain (NCBI)SLC9A8
SuperfamilyQ9Y2E8
AlphaFold pdb e-kbQ9Y2E8   
Human Protein Atlas [tissue]ENSG00000197818-SLC9A8 [tissue]
HPRD18062
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2E8
IntAct (EBI)Q9Y2E8
BioGRIDSLC9A8
STRING (EMBL)SLC9A8
ZODIACSLC9A8
Ontologies - Pathways
QuickGOQ9Y2E8
Ontology : AmiGOGolgi membrane  protein binding  Golgi apparatus  ion transport  sodium:proton antiporter activity  potassium:proton antiporter activity  integral component of membrane  sodium ion transmembrane transport  regulation of intracellular pH  potassium ion transmembrane transport  anion transmembrane transport  proton transmembrane transport  
Ontology : EGO-EBIGolgi membrane  protein binding  Golgi apparatus  ion transport  sodium:proton antiporter activity  potassium:proton antiporter activity  integral component of membrane  sodium ion transmembrane transport  regulation of intracellular pH  potassium ion transmembrane transport  anion transmembrane transport  proton transmembrane transport  
NDEx NetworkSLC9A8
Atlas of Cancer Signalling NetworkSLC9A8
Wikipedia pathwaysSLC9A8
Orthology - Evolution
OrthoDB23315
GeneTree (enSembl)ENSG00000197818
Phylogenetic Trees/Animal Genes : TreeFamSLC9A8
Homologs : HomoloGeneSLC9A8
Homology/Alignments : Family Browser (UCSC)SLC9A8
Gene fusions - Rearrangements
Fusion : MitelmanPTPN1/SLC9A8 [20q13.13/20q13.13]  
Fusion : MitelmanSLC9A8/CCDC64B [20q13.13/16p13.3]  
Fusion : MitelmanSLC9A8/RAE1 [20q13.13/20q13.31]  
Fusion : MitelmanSNAI1/SLC9A8 [20q13.13/20q13.13]  
Fusion : MitelmanZC3H7B/SLC9A8 [22q13.2/20q13.13]  
Fusion : MitelmanZFP28/SLC9A8 [19q13.43/20q13.13]  
Fusion : QuiverSLC9A8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC9A8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC9A8
dbVarSLC9A8
ClinVarSLC9A8
MonarchSLC9A8
1000_GenomesSLC9A8 
Exome Variant ServerSLC9A8
GNOMAD BrowserENSG00000197818
Varsome BrowserSLC9A8
ACMGSLC9A8 variants
VarityQ9Y2E8
Genomic Variants (DGV)SLC9A8 [DGVbeta]
DECIPHERSLC9A8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC9A8 
Mutations
ICGC Data PortalSLC9A8 
TCGA Data PortalSLC9A8 
Broad Tumor PortalSLC9A8
OASIS PortalSLC9A8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC9A8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSLC9A8
Mutations and Diseases : HGMDSLC9A8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSLC9A8
DgiDB (Drug Gene Interaction Database)SLC9A8
DoCM (Curated mutations)SLC9A8
CIViC (Clinical Interpretations of Variants in Cancer)SLC9A8
Cancer3DSLC9A8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612730   
Orphanet
DisGeNETSLC9A8
MedgenSLC9A8
Genetic Testing Registry SLC9A8
NextProtQ9Y2E8 [Medical]
GENETestsSLC9A8
Target ValidationSLC9A8
Huge Navigator SLC9A8 [HugePedia]
ClinGenSLC9A8
Clinical trials, drugs, therapy
MyCancerGenomeSLC9A8
Protein Interactions : CTDSLC9A8
Pharm GKB GenePA134924114
PharosQ9Y2E8
Clinical trialSLC9A8
Miscellaneous
canSAR (ICR)SLC9A8
HarmonizomeSLC9A8
DataMed IndexSLC9A8
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSLC9A8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:01 CEST 2021

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