SLC9B2 (solute carrier family 9 member B2)

2003-05-01  

Identity

HGNC
SLC9B2
LOCATION
4q24
LOCUSID
133308
ALIAS
NHA2,NHE10,NHEDC2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 133308
MIM: 611789
HGNC: 25143
Ensembl: ENSG00000164038

Variants:

dbSNP: 133308
ClinVar: 133308
TCGA: ENSG00000164038
COSMIC: SLC9B2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164038ENST00000362026Q86UD5
ENSG00000164038ENST00000362026A0A024RDJ7
ENSG00000164038ENST00000394785Q86UD5
ENSG00000164038ENST00000394785A0A024RDJ7
ENSG00000164038ENST00000503103B7Z676
ENSG00000164038ENST00000503230E9PE63
ENSG00000164038ENST00000503818D6RGJ7
ENSG00000164038ENST00000506288A0A0C4DGB3
ENSG00000164038ENST00000508136D6R9P2

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
180000462007A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension.29
185089662008Characterization of the sodium/hydrogen exchanger NHA2.18
200533532010Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension.18
179889712008NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts.12
229481422012Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradient.11
281541422017Dissecting the proton transport pathway in electrogenic Na+/H+ antiporters.10
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8
207131312010Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiae.2

Citation

Dessen P

SLC9B2 (solute carrier family 9 member B2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41169/slc9b2