SLCO1A2 (solute carrier organic anion transporter family member 1A2)

2008-12-01 Affiliation

Identity

HGNC

SLCO1A2

LOCATION

12p12.1

LOCUSID

6579

ALIAS

OATP,OATP-A,OATP1A2,SLC21A3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6579
MIM: 602883
HGNC: 10956
Ensembl: ENSG00000084453

Variants:

dbSNP: 6579
ClinVar: 6579
TCGA: ENSG00000084453
COSMIC: SLCO1A2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000084453	ENST00000307378	P46721
ENSG00000084453	ENST00000307378	A0A024RAT5
ENSG00000084453	ENST00000413682	C9JCA7
ENSG00000084453	ENST00000416627	C9IYW8
ENSG00000084453	ENST00000421287	C9JG34
ENSG00000084453	ENST00000421294	C9JGK7
ENSG00000084453	ENST00000422327	C9JHU9
ENSG00000084453	ENST00000435179	C9K059
ENSG00000084453	ENST00000445053	C9JSB7
ENSG00000084453	ENST00000450590	C9JUW6
ENSG00000084453	ENST00000453443	C9JTF6
ENSG00000084453	ENST00000458504	B4DJE6
ENSG00000084453	ENST00000544020	F5GXY6
ENSG00000084453	ENST00000544290	F5H060

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Bile secretion	KEGG	ko04976
Bile secretion	KEGG	hsa04976
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of vitamins, nucleosides, and related molecules	REACTOME	R-HSA-425397
Transport of organic anions	REACTOME	R-HSA-879518
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Bile acid and bile salt metabolism	REACTOME	R-HSA-194068
Recycling of bile acids and salts	REACTOME	R-HSA-159418

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PMIDs
PA10804	imatinib	Chemical	ClinicalAnnotation	associated	PK	21633340
PA133950441	hmg coa reductase inhibitors	Chemical	Pathway	associated
PA164754992	rocuronium	Chemical	ClinicalAnnotation	associated	PK	28409297
PA446171	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Disease	ClinicalAnnotation	associated	PK	21633340
PA450428	methotrexate	Chemical	Pathway	associated		21317831
PA450573	nadolol	Chemical	Literature, MultilinkAnnotation	associated		24419562

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15632119	2005	Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.	74
15632119	2005	Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.	74
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
20051929	2010	HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.	56
19010908	2008	Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer.	40
19890249	2010	The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.	31
22864060	2012	Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions.	27
15832500	2004	Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells.	26
20416077	2010	Identification of type 2 diabetes-associated combination of SNPs using support vector machine.	26

Citation

Dessen P

SLCO1A2 (solute carrier organic anion transporter family member 1A2)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50582/slco1a2