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SLCO1B3 (solute carrier organic anion transporter family member 1B3)

Identity

Alias (NCBI)HBLRR
LST-2
LST-3TM13
LST3
OATP-8
OATP1B3
OATP8
SLC21A8
HGNC (Hugo) SLCO1B3
HGNC Alias symbOATP8
OATP1B3
HGNC Previous nameSLC21A8
HGNC Previous namesolute carrier family 21 (organic anion transporter), member 8
 solute carrier organic anion transporter family, member 1B3
LocusID (NCBI) 28234
Atlas_Id 46289
Location 12p12.2  [Link to chromosome band 12p12]
Location_base_pair Starts at 20810705 and ends at 20916909 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PAX5 (9p13.2) / SLCO1B3 (12p12.2)SLCO1B3 (12p12.2) / SLCO1B7 (12p12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  dic(9;12)(p13;p13) PAX5/ETV6
dic(9;12)(p13;p12) PAX5/SLCO1B3


External links

Nomenclature
HGNC (Hugo)SLCO1B3   10961
Cards
Entrez_Gene (NCBI)SLCO1B3    solute carrier organic anion transporter family member 1B3
AliasesHBLRR; LST-2; LST-3TM13; LST3; 
OATP-8; OATP1B3; OATP8; SLC21A8
GeneCards (Weizmann)SLCO1B3
Ensembl hg19 (Hinxton)ENSG00000111700 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111700 [Gene_View]  ENSG00000111700 [Sequence]  chr12:20810705-20916909 [Contig_View]  SLCO1B3 [Vega]
ICGC DataPortalENSG00000111700
TCGA cBioPortalSLCO1B3
AceView (NCBI)SLCO1B3
Genatlas (Paris)SLCO1B3
SOURCE (Princeton)SLCO1B3
Genetics Home Reference (NIH)SLCO1B3
Genomic and cartography
GoldenPath hg38 (UCSC)SLCO1B3  -     chr12:20810705-20916909 +  12p12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLCO1B3  -     12p12.2   [Description]    (hg19-Feb_2009)
GoldenPathSLCO1B3 - 12p12.2 [CytoView hg19]  SLCO1B3 - 12p12.2 [CytoView hg38]
ImmunoBaseENSG00000111700
genome Data Viewer NCBISLCO1B3 [Mapview hg19]  
OMIM237450   605495   
Gene and transcription
Genbank (Entrez)AB669023 AF187815 AJ251506 AK055874 AY342017
RefSeq transcript (Entrez)NM_001349920 NM_019844
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLCO1B3
Alternative Splicing GalleryENSG00000111700
Gene ExpressionSLCO1B3 [ NCBI-GEO ]   SLCO1B3 [ EBI - ARRAY_EXPRESS ]   SLCO1B3 [ SEEK ]   SLCO1B3 [ MEM ]
Gene Expression Viewer (FireBrowse)SLCO1B3 [ Firebrowse - Broad ]
GenevisibleExpression of SLCO1B3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)28234
GTEX Portal (Tissue expression)SLCO1B3
Human Protein AtlasENSG00000111700-SLCO1B3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPD5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPD5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPD5
Splice isoforms : SwissVarQ9NPD5
PhosPhoSitePlusQ9NPD5
Domaine pattern : Prosite (Expaxy)KAZAL_2 (PS51465)    MFS (PS50850)   
Domains : Interpro (EBI)Kazal_dom    Kazal_dom_sf    MFS_dom    MFS_trans_sf    OATP   
Domain families : Pfam (Sanger)Kazal_2 (PF07648)    OATP (PF03137)   
Domain families : Pfam (NCBI)pfam07648    pfam03137   
Conserved Domain (NCBI)SLCO1B3
Blocks (Seattle)SLCO1B3
SuperfamilyQ9NPD5
Human Protein Atlas [tissue]ENSG00000111700-SLCO1B3 [tissue]
Peptide AtlasQ9NPD5
HPRD12021
IPIIPI00902630   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPD5
IntAct (EBI)Q9NPD5
BioGRIDSLCO1B3
STRING (EMBL)SLCO1B3
ZODIACSLCO1B3
Ontologies - Pathways
QuickGOQ9NPD5
Ontology : AmiGOplasma membrane  plasma membrane  integral component of plasma membrane  organic anion transmembrane transporter activity  bile acid transmembrane transporter activity  bile acid transmembrane transporter activity  sodium-independent organic anion transmembrane transporter activity  organic anion transport  bile acid and bile salt transport  bile acid and bile salt transport  basolateral plasma membrane  sodium-independent organic anion transport  sodium-independent organic anion transport  transmembrane transport  
Ontology : EGO-EBIplasma membrane  plasma membrane  integral component of plasma membrane  organic anion transmembrane transporter activity  bile acid transmembrane transporter activity  bile acid transmembrane transporter activity  sodium-independent organic anion transmembrane transporter activity  organic anion transport  bile acid and bile salt transport  bile acid and bile salt transport  basolateral plasma membrane  sodium-independent organic anion transport  sodium-independent organic anion transport  transmembrane transport  
Pathways : KEGGBile secretion   
NDEx NetworkSLCO1B3
Atlas of Cancer Signalling NetworkSLCO1B3
Wikipedia pathwaysSLCO1B3
Orthology - Evolution
OrthoDB28234
GeneTree (enSembl)ENSG00000111700
Phylogenetic Trees/Animal Genes : TreeFamSLCO1B3
HOGENOMQ9NPD5
Homologs : HomoloGeneSLCO1B3
Homology/Alignments : Family Browser (UCSC)SLCO1B3
Gene fusions - Rearrangements
Fusion : MitelmanPAX5/SLCO1B3 [9p13.2/12p12.2]  
Fusion Cancer (Beijing)SLCO1B3 [12p12.2]  -  SLCO1B7 [12p12.2]  [FUSC003252]
Fusion : QuiverSLCO1B3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLCO1B3 [hg38]
dbVarSLCO1B3
ClinVarSLCO1B3
MonarchSLCO1B3
1000_GenomesSLCO1B3 
Exome Variant ServerSLCO1B3
GNOMAD BrowserENSG00000111700
Varsome BrowserSLCO1B3
Genomic Variants (DGV)SLCO1B3 [DGVbeta]
DECIPHERSLCO1B3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLCO1B3 
Mutations
ICGC Data PortalSLCO1B3 
TCGA Data PortalSLCO1B3 
Broad Tumor PortalSLCO1B3
OASIS PortalSLCO1B3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLCO1B3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSLCO1B3
Mutations and Diseases : HGMDSLCO1B3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLCO1B3
DgiDB (Drug Gene Interaction Database)SLCO1B3
DoCM (Curated mutations)SLCO1B3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLCO1B3 (select a term)
intoGenSLCO1B3
Cancer3DSLCO1B3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM237450    605495   
Orphanet882   
DisGeNETSLCO1B3
MedgenSLCO1B3
Genetic Testing Registry SLCO1B3
NextProtQ9NPD5 [Medical]
GENETestsSLCO1B3
Target ValidationSLCO1B3
Huge Navigator SLCO1B3 [HugePedia]
ClinGenSLCO1B3
Clinical trials, drugs, therapy
MyCancerGenomeSLCO1B3
Protein Interactions : CTD
Pharm GKB GenePA35844
Pharm GKB PathwaysPA145011108   PA145011109   PA145011110   PA145011111   PA145011112   PA154426155   PA165816349   PA166041114   
PharosQ9NPD5
Clinical trialSLCO1B3
Miscellaneous
canSAR (ICR)SLCO1B3 (select the gene name)
HarmonizomeSLCO1B3
DataMed IndexSLCO1B3
Probes
Litterature
PubMed147 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSLCO1B3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:46:31 CET 2021

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