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SLCO2A1 (solute carrier organic anion transporter family member 2A1)

Identity

Alias_namesSLC21A2
MATR1
solute carrier family 21 (prostaglandin transporter), member 2
matrin F/G 1
solute carrier organic anion transporter family, member 2A1
Alias_symbol (synonym)PGT
OATP2A1
Other aliasPHOAR2
HGNC (Hugo) SLCO2A1
LocusID (NCBI) 6578
Atlas_Id 54642
Location 3q22.1  [Link to chromosome band 3q22]
Location_base_pair Starts at 133932696 and ends at 134030076 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LOC100507412 (-) / SLCO2A1 (3q22.1)MGLL (3q21.3) / SLCO2A1 (3q22.1)SLCO2A1 (3q22.1) / DAG1 (3p21.31)
SLCO2A1 (3q22.1) / GUCA1C (3q13.13)SLCO2A1 (3q22.1) / RREB1 (6p24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Adenocarcinoma
Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)SLCO2A1   10955
LRG (Locus Reference Genomic)LRG_841
Cards
Entrez_Gene (NCBI)SLCO2A1  6578  solute carrier organic anion transporter family member 2A1
AliasesMATR1; OATP2A1; PGT; PHOAR2; 
SLC21A2
GeneCards (Weizmann)SLCO2A1
Ensembl hg19 (Hinxton)ENSG00000174640 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174640 [Gene_View]  chr3:133932696-134030076 [Contig_View]  SLCO2A1 [Vega]
ICGC DataPortalENSG00000174640
TCGA cBioPortalSLCO2A1
AceView (NCBI)SLCO2A1
Genatlas (Paris)SLCO2A1
WikiGenes6578
SOURCE (Princeton)SLCO2A1
Genetics Home Reference (NIH)SLCO2A1
Genomic and cartography
GoldenPath hg38 (UCSC)SLCO2A1  -     chr3:133932696-134030076 -  3q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLCO2A1  -     3q22.1   [Description]    (hg19-Feb_2009)
EnsemblSLCO2A1 - 3q22.1 [CytoView hg19]  SLCO2A1 - 3q22.1 [CytoView hg38]
Mapping of homologs : NCBISLCO2A1 [Mapview hg19]  SLCO2A1 [Mapview hg38]
OMIM601460   614441   
Gene and transcription
Genbank (Entrez)AK303550 AK309561 BC041140 BC051347 BU783445
RefSeq transcript (Entrez)NM_005630
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLCO2A1
Cluster EST : UnigeneHs.518270 [ NCBI ]
CGAP (NCI)Hs.518270
Alternative Splicing GalleryENSG00000174640
Gene ExpressionSLCO2A1 [ NCBI-GEO ]   SLCO2A1 [ EBI - ARRAY_EXPRESS ]   SLCO2A1 [ SEEK ]   SLCO2A1 [ MEM ]
Gene Expression Viewer (FireBrowse)SLCO2A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6578
GTEX Portal (Tissue expression)SLCO2A1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92959   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92959  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92959
Splice isoforms : SwissVarQ92959
PhosPhoSitePlusQ92959
Domaine pattern : Prosite (Expaxy)KAZAL_2 (PS51465)    MFS (PS50850)   
Domains : Interpro (EBI)Kazal_dom    MFS_dom    OA_transporter   
Domain families : Pfam (Sanger)Kazal_2 (PF07648)    OATP (PF03137)   
Domain families : Pfam (NCBI)pfam07648    pfam03137   
Conserved Domain (NCBI)SLCO2A1
DMDM Disease mutations6578
Blocks (Seattle)SLCO2A1
PDB (SRS)3MRR   
PDB (PDBSum)3MRR   
PDB (IMB)3MRR   
PDB (RSDB)3MRR   
Structural Biology KnowledgeBase3MRR   
SCOP (Structural Classification of Proteins)3MRR   
CATH (Classification of proteins structures)3MRR   
SuperfamilyQ92959
Human Protein AtlasENSG00000174640
Peptide AtlasQ92959
HPRD03269
IPIIPI00295132   IPI00797664   IPI00946964   
Protein Interaction databases
DIP (DOE-UCLA)Q92959
IntAct (EBI)Q92959
FunCoupENSG00000174640
BioGRIDSLCO2A1
STRING (EMBL)SLCO2A1
ZODIACSLCO2A1
Ontologies - Pathways
QuickGOQ92959
Ontology : AmiGOlipid transporter activity  plasma membrane  integral component of plasma membrane  lipid transport  prostaglandin transmembrane transporter activity  prostaglandin transport  membrane  sodium-independent organic anion transport  
Ontology : EGO-EBIlipid transporter activity  plasma membrane  integral component of plasma membrane  lipid transport  prostaglandin transmembrane transporter activity  prostaglandin transport  membrane  sodium-independent organic anion transport  
NDEx NetworkSLCO2A1
Atlas of Cancer Signalling NetworkSLCO2A1
Wikipedia pathwaysSLCO2A1
Orthology$- Evmletion
OrthoDB6578
GeneTree (enSembl)ENSG00000174640
Phylogenetic Trees/Animal Genes : TreeFamSLCO2A1
HOVERGENQ92959
HOGENOMQ92959
Homologs : HomoloGeneSLCO2A1
Homology/Alignments : Family Browser (UCSC)SLCO2A1
Gene fusions - Rearrangements
Fusion : MitelmanMGLL/SLCO2A1 [3q21.3/3q22.1]  [t(3;3)(q21;q22)]  
Fusion : MitelmanSLCO2A1/GUCA1C [3q22.1/3q13.13]  [t(3;3)(q13;q22)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLCO2A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLCO2A1
dbVarSLCO2A1
ClinVarSLCO2A1
1000_GenomesSLCO2A1 
Exome Variant ServerSLCO2A1
ExAC (Exome Aggregation Consortium)SLCO2A1 (select the gene name)
Genetic variants : HAPMAP6578
Genomic Variants (DGV)SLCO2A1 [DGVbeta]
DECIPHERSLCO2A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLCO2A1 
Mutations
ICGC Data PortalSLCO2A1 
TCGA Data PortalSLCO2A1 
Broad Tumor PortalSLCO2A1
OASIS PortalSLCO2A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLCO2A1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLCO2A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch SLCO2A1
DgiDB (Drug Gene Interaction Database)SLCO2A1
DoCM (Curated mutations)SLCO2A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLCO2A1 (select a term)
intoGenSLCO2A1
Cancer3DSLCO2A1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601460    614441   
Orphanet2542   
MedgenSLCO2A1
Genetic Testing Registry SLCO2A1
NextProtQ92959 [Medical]
TSGene6578
GENETestsSLCO2A1
Target ValidationSLCO2A1
Huge Navigator SLCO2A1 [HugePedia]
snp3D : Map Gene to Disease6578
BioCentury BCIQSLCO2A1
ClinGenSLCO2A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6578
Chemical/Pharm GKB GenePA35840
Clinical trialSLCO2A1
Miscellaneous
canSAR (ICR)SLCO2A1 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLCO2A1
EVEXSLCO2A1
GoPubMedSLCO2A1
iHOPSLCO2A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:31:55 CEST 2017

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