Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SLCO2B1 (solute carrier organic anion transporter family member 2B1)

Identity

Alias_namesSLC21A9
solute carrier family 21 (organic anion transporter), member 9
solute carrier organic anion transporter family, member 2B1
Alias_symbol (synonym)OATP-B
OATP2B1
Other aliasOATPB
HGNC (Hugo) SLCO2B1
LocusID (NCBI) 11309
Atlas_Id 52268
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 75150987 and ends at 75206400 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AMOTL1 (11q21) / SLCO2B1 (11q13.4)SLCO2B1 (11q13.4) / FURIN (15q26.1)SLCO2B1 (11q13.4) / HNF4A (20q13.12)
SLCO2B1 (11q13.4) / SLCO2B1 (11q13.4)AMOTL1 11q21 / SLCO2B1 11q13.4SLCO2B1 11q13.4 / HNF4A 20q13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;11)(q13;q21) AMOTL1/SLCO2B1
t(11;20)(q13;q13) SLCO2B1/HNF4A

External links

Nomenclature
HGNC (Hugo)SLCO2B1   10962
Cards
Entrez_Gene (NCBI)SLCO2B1  11309  solute carrier organic anion transporter family member 2B1
AliasesOATP-B; OATP2B1; OATPB; SLC21A9
GeneCards (Weizmann)SLCO2B1
Ensembl hg19 (Hinxton)ENSG00000137491 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137491 [Gene_View]  ENSG00000137491 [Sequence]  chr11:75150987-75206400 [Contig_View]  SLCO2B1 [Vega]
ICGC DataPortalENSG00000137491
TCGA cBioPortalSLCO2B1
AceView (NCBI)SLCO2B1
Genatlas (Paris)SLCO2B1
WikiGenes11309
SOURCE (Princeton)SLCO2B1
Genetics Home Reference (NIH)SLCO2B1
Genomic and cartography
GoldenPath hg38 (UCSC)SLCO2B1  -     chr11:75150987-75206400 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLCO2B1  -     11q13.4   [Description]    (hg19-Feb_2009)
EnsemblSLCO2B1 - 11q13.4 [CytoView hg19]  SLCO2B1 - 11q13.4 [CytoView hg38]
Mapping of homologs : NCBISLCO2B1 [Mapview hg19]  SLCO2B1 [Mapview hg38]
OMIM604988   
Gene and transcription
Genbank (Entrez)AB020687 AB026256 AF205073 AK127289 AK127363
RefSeq transcript (Entrez)NM_001145211 NM_001145212 NM_007256
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLCO2B1
Cluster EST : UnigeneHs.7884 [ NCBI ]
CGAP (NCI)Hs.7884
Alternative Splicing GalleryENSG00000137491
Gene ExpressionSLCO2B1 [ NCBI-GEO ]   SLCO2B1 [ EBI - ARRAY_EXPRESS ]   SLCO2B1 [ SEEK ]   SLCO2B1 [ MEM ]
Gene Expression Viewer (FireBrowse)SLCO2B1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11309
GTEX Portal (Tissue expression)SLCO2B1
Human Protein AtlasENSG00000137491-SLCO2B1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94956   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94956  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94956
Splice isoforms : SwissVarO94956
PhosPhoSitePlusO94956
Domaine pattern : Prosite (Expaxy)KAZAL_2 (PS51465)   
Domains : Interpro (EBI)Kazal_dom    MFS_dom    MFS_trans_sf    OATP   
Domain families : Pfam (Sanger)OATP (PF03137)   
Domain families : Pfam (NCBI)pfam03137   
Conserved Domain (NCBI)SLCO2B1
DMDM Disease mutations11309
Blocks (Seattle)SLCO2B1
SuperfamilyO94956
Human Protein Atlas [tissue]ENSG00000137491-SLCO2B1 [tissue]
Peptide AtlasO94956
HPRD07061
IPIIPI00016553   IPI00220023   IPI00977671   IPI00976510   IPI00976999   IPI00978554   IPI00983284   IPI00979251   IPI00975837   IPI00922946   IPI00979806   
Protein Interaction databases
DIP (DOE-UCLA)O94956
IntAct (EBI)O94956
FunCoupENSG00000137491
BioGRIDSLCO2B1
STRING (EMBL)SLCO2B1
ZODIACSLCO2B1
Ontologies - Pathways
QuickGOO94956
Ontology : AmiGOplasma membrane  integral component of plasma membrane  organic anion transmembrane transporter activity  bile acid transmembrane transporter activity  sodium-independent organic anion transmembrane transporter activity  sodium-independent organic anion transmembrane transporter activity  sodium-independent organic anion transmembrane transporter activity  bile acid and bile salt transport  sodium-independent organic anion transport  sodium-independent organic anion transport  transmembrane transport  
Ontology : EGO-EBIplasma membrane  integral component of plasma membrane  organic anion transmembrane transporter activity  bile acid transmembrane transporter activity  sodium-independent organic anion transmembrane transporter activity  sodium-independent organic anion transmembrane transporter activity  sodium-independent organic anion transmembrane transporter activity  bile acid and bile salt transport  sodium-independent organic anion transport  sodium-independent organic anion transport  transmembrane transport  
NDEx NetworkSLCO2B1
Atlas of Cancer Signalling NetworkSLCO2B1
Wikipedia pathwaysSLCO2B1
Orthology - Evolution
OrthoDB11309
GeneTree (enSembl)ENSG00000137491
Phylogenetic Trees/Animal Genes : TreeFamSLCO2B1
HOGENOMO94956
Homologs : HomoloGeneSLCO2B1
Homology/Alignments : Family Browser (UCSC)SLCO2B1
Gene fusions - Rearrangements
Fusion : MitelmanAMOTL1/SLCO2B1 [11q21/11q13.4]  [t(11;11)(q13;q21)]  
Fusion : MitelmanSLCO2B1/HNF4A [11q13.4/20q13.12]  [t(11;20)(q13;q13)]  
Fusion PortalAMOTL1 11q21 SLCO2B1 11q13.4 BLCA
Fusion PortalSLCO2B1 11q13.4 HNF4A 20q13.12 KIRC
Fusion : QuiverSLCO2B1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLCO2B1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLCO2B1
dbVarSLCO2B1
ClinVarSLCO2B1
1000_GenomesSLCO2B1 
Exome Variant ServerSLCO2B1
ExAC (Exome Aggregation Consortium)ENSG00000137491
GNOMAD BrowserENSG00000137491
Varsome BrowserSLCO2B1
Genetic variants : HAPMAP11309
Genomic Variants (DGV)SLCO2B1 [DGVbeta]
DECIPHERSLCO2B1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLCO2B1 
Mutations
ICGC Data PortalSLCO2B1 
TCGA Data PortalSLCO2B1 
Broad Tumor PortalSLCO2B1
OASIS PortalSLCO2B1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLCO2B1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLCO2B1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLCO2B1
DgiDB (Drug Gene Interaction Database)SLCO2B1
DoCM (Curated mutations)SLCO2B1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLCO2B1 (select a term)
intoGenSLCO2B1
Cancer3DSLCO2B1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604988   
Orphanet
DisGeNETSLCO2B1
MedgenSLCO2B1
Genetic Testing Registry SLCO2B1
NextProtO94956 [Medical]
TSGene11309
GENETestsSLCO2B1
Target ValidationSLCO2B1
Huge Navigator SLCO2B1 [HugePedia]
snp3D : Map Gene to Disease11309
BioCentury BCIQSLCO2B1
ClinGenSLCO2B1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11309
Chemical/Pharm GKB GenePA35845
Clinical trialSLCO2B1
Miscellaneous
canSAR (ICR)SLCO2B1 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLCO2B1
EVEXSLCO2B1
GoPubMedSLCO2B1
iHOPSLCO2B1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Dec 21 15:52:42 CET 2018
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