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SLCO2B1 (solute carrier organic anion transporter family member 2B1)

Identity

Alias (NCBI)OATP-B
OATP2B1
OATPB
SLC21A9
HGNC (Hugo) SLCO2B1
HGNC Alias symbOATP-B
OATP2B1
HGNC Previous nameSLC21A9
HGNC Previous namesolute carrier family 21 (organic anion transporter), member 9
 solute carrier organic anion transporter family, member 2B1
LocusID (NCBI) 11309
Atlas_Id 52268
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 75151107 and ends at 75206549 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AMOTL1 (11q21) / SLCO2B1 (11q13.4)SLCO2B1 (11q13.4) / FURIN (15q26.1)SLCO2B1 (11q13.4) / HNF4A (20q13.12)
SLCO2B1 (11q13.4) / SLCO2B1 (11q13.4)AMOTL1 11q21 / SLCO2B1 11q13.4SLCO2B1 11q13.4 / HNF4A 20q13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SLCO2B1   10962
Cards
Entrez_Gene (NCBI)SLCO2B1    solute carrier organic anion transporter family member 2B1
AliasesOATP-B; OATP2B1; OATPB; SLC21A9
GeneCards (Weizmann)SLCO2B1
Ensembl hg19 (Hinxton)ENSG00000137491 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137491 [Gene_View]  ENSG00000137491 [Sequence]  chr11:75151107-75206549 [Contig_View]  SLCO2B1 [Vega]
ICGC DataPortalENSG00000137491
TCGA cBioPortalSLCO2B1
AceView (NCBI)SLCO2B1
Genatlas (Paris)SLCO2B1
SOURCE (Princeton)SLCO2B1
Genetics Home Reference (NIH)SLCO2B1
Genomic and cartography
GoldenPath hg38 (UCSC)SLCO2B1  -     chr11:75151107-75206549 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLCO2B1  -     11q13.4   [Description]    (hg19-Feb_2009)
GoldenPathSLCO2B1 - 11q13.4 [CytoView hg19]  SLCO2B1 - 11q13.4 [CytoView hg38]
ImmunoBaseENSG00000137491
Genome Data Viewer NCBISLCO2B1 [Mapview hg19]  
OMIM604988   
Gene and transcription
Genbank (Entrez)AB020687 AB026256 AF205073 AK127289 AK127363
RefSeq transcript (Entrez)NM_001145211 NM_001145212 NM_007256
Consensus coding sequences : CCDS (NCBI)SLCO2B1
Gene ExpressionSLCO2B1 [ NCBI-GEO ]   SLCO2B1 [ EBI - ARRAY_EXPRESS ]   SLCO2B1 [ SEEK ]   SLCO2B1 [ MEM ]
Gene Expression Viewer (FireBrowse)SLCO2B1 [ Firebrowse - Broad ]
GenevisibleExpression of SLCO2B1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11309
GTEX Portal (Tissue expression)SLCO2B1
Human Protein AtlasENSG00000137491-SLCO2B1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94956   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94956  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94956
PhosPhoSitePlusO94956
Domaine pattern : Prosite (Expaxy)KAZAL_2 (PS51465)   
Domains : Interpro (EBI)Kazal_dom    MFS_trans_sf    OATP   
Domain families : Pfam (Sanger)OATP (PF03137)   
Domain families : Pfam (NCBI)pfam03137   
Conserved Domain (NCBI)SLCO2B1
SuperfamilyO94956
AlphaFold pdb e-kbO94956   
Human Protein Atlas [tissue]ENSG00000137491-SLCO2B1 [tissue]
HPRD07061
Protein Interaction databases
DIP (DOE-UCLA)O94956
IntAct (EBI)O94956
BioGRIDSLCO2B1
STRING (EMBL)SLCO2B1
ZODIACSLCO2B1
Ontologies - Pathways
QuickGOO94956
Ontology : AmiGOplasma membrane  plasma membrane  integral component of plasma membrane  organic anion transmembrane transporter activity  bile acid transmembrane transporter activity  sodium-independent organic anion transmembrane transporter activity  sodium-independent organic anion transmembrane transporter activity  organic anion transport  bile acid and bile salt transport  apical plasma membrane  apical plasma membrane  heme catabolic process  sodium-independent organic anion transport  sodium-independent organic anion transport  transmembrane transport  transmembrane transport  transport across blood-brain barrier  
Ontology : EGO-EBIplasma membrane  plasma membrane  integral component of plasma membrane  organic anion transmembrane transporter activity  bile acid transmembrane transporter activity  sodium-independent organic anion transmembrane transporter activity  sodium-independent organic anion transmembrane transporter activity  organic anion transport  bile acid and bile salt transport  apical plasma membrane  apical plasma membrane  heme catabolic process  sodium-independent organic anion transport  sodium-independent organic anion transport  transmembrane transport  transmembrane transport  transport across blood-brain barrier  
NDEx NetworkSLCO2B1
Atlas of Cancer Signalling NetworkSLCO2B1
Wikipedia pathwaysSLCO2B1
Orthology - Evolution
OrthoDB11309
GeneTree (enSembl)ENSG00000137491
Phylogenetic Trees/Animal Genes : TreeFamSLCO2B1
Homologs : HomoloGeneSLCO2B1
Homology/Alignments : Family Browser (UCSC)SLCO2B1
Gene fusions - Rearrangements
Fusion : MitelmanAMOTL1/SLCO2B1 [11q21/11q13.4]  
Fusion : MitelmanSLCO2B1/HNF4A [11q13.4/20q13.12]  
Fusion : QuiverSLCO2B1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLCO2B1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLCO2B1
dbVarSLCO2B1
ClinVarSLCO2B1
MonarchSLCO2B1
1000_GenomesSLCO2B1 
Exome Variant ServerSLCO2B1
GNOMAD BrowserENSG00000137491
Varsome BrowserSLCO2B1
ACMGSLCO2B1 variants
VarityO94956
Genomic Variants (DGV)SLCO2B1 [DGVbeta]
DECIPHERSLCO2B1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLCO2B1 
Mutations
ICGC Data PortalSLCO2B1 
TCGA Data PortalSLCO2B1 
Broad Tumor PortalSLCO2B1
OASIS PortalSLCO2B1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLCO2B1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSLCO2B1
Mutations and Diseases : HGMDSLCO2B1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSLCO2B1
DgiDB (Drug Gene Interaction Database)SLCO2B1
DoCM (Curated mutations)SLCO2B1
CIViC (Clinical Interpretations of Variants in Cancer)SLCO2B1
Cancer3DSLCO2B1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604988   
Orphanet
DisGeNETSLCO2B1
MedgenSLCO2B1
Genetic Testing Registry SLCO2B1
NextProtO94956 [Medical]
GENETestsSLCO2B1
Target ValidationSLCO2B1
Huge Navigator SLCO2B1 [HugePedia]
ClinGenSLCO2B1
Clinical trials, drugs, therapy
MyCancerGenomeSLCO2B1
Protein Interactions : CTDSLCO2B1
Pharm GKB GenePA35845
Pharm GKB PathwaysPA145011108   PA145011109   PA145011110   PA145011111   PA145011112   
PharosO94956
Clinical trialSLCO2B1
Miscellaneous
canSAR (ICR)SLCO2B1
HarmonizomeSLCO2B1
DataMed IndexSLCO2B1
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSLCO2B1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:03 CEST 2021

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