SLCO4A1 (solute carrier organic anion transporter family member 4A1)

2015-03-01  

Identity

HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
OATP-E,OATP1,OATP4A1,OATPE,OATPRP1,POAT,SLC21A12
FUSION GENES

Other Information

Locus ID:

NCBI: 28231
MIM: 612436
HGNC: 10953
Ensembl: ENSG00000101187

Variants:

dbSNP: 28231
ClinVar: 28231
TCGA: ENSG00000101187
COSMIC: SLCO4A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101187ENST00000217159Q96BD0
ENSG00000101187ENST00000370507Q96BD0
ENSG00000101187ENST00000451793A0A0A0MT51
ENSG00000101187ENST00000497209E1P5H9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of organic anionsREACTOMER-HSA-879518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159943322005Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface.23
214867662011The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation.11
253014522015Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy.6
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.3
283780902017Solute carrier organic anion transporter family member 4A1 (SLCO4A1) as a prognosis marker of colorectal cancer.3
263499912015Effect of DNA methylation profile on OATP3A1 and OATP4A1 transcript levels in colorectal cancer.1
297342532019Abundance of the Organic Anion-transporting Polypeptide OATP4A1 in Early-Stage Colorectal Cancer Patients: Association With Disease Relapse.0

Citation

Dessen P

SLCO4A1 (solute carrier organic anion transporter family member 4A1)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55131/slco4a1