Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SLCO4A1 (solute carrier organic anion transporter family member 4A1)

Identity

Alias_namesSLC21A12
solute carrier family 21 (organic anion transporter), member 12
solute carrier organic anion transporter family, member 4A1
Alias_symbol (synonym)OATP-E
OATP4A1
Other aliasOATP1
OATPE
OATPRP1
POAT
HGNC (Hugo) SLCO4A1
LocusID (NCBI) 28231
Atlas_Id 55131
Location 20q13.33  [Link to chromosome band 20q13]
Location_base_pair Starts at 62642445 and ends at 62672295 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
B4GALNT3 (12p13.33) / SLCO4A1 (20q13.33)CACNA2D2 (3p21.31) / SLCO4A1 (20q13.33)IFITM2 (11p15.5) / SLCO4A1 (20q13.33)
SLCO4A1 (20q13.33) / ADRM1 (20q13.33)SLCO4A1 (20q13.33) / GCDH (19p13.2)SLCO4A1 (20q13.33) / SLCO4A1 (20q13.33)
SLCO4A1 (20q13.33) / ZNF691 (1p34.2)B4GALNT3 12p13.33 / SLCO4A1 20q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;20)(p13;q13) B4GALNT3/SLCO4A1

External links

Nomenclature
HGNC (Hugo)SLCO4A1   10953
Cards
Entrez_Gene (NCBI)SLCO4A1  28231  solute carrier organic anion transporter family member 4A1
AliasesOATP-E; OATP1; OATP4A1; OATPE; 
OATPRP1; POAT; SLC21A12
GeneCards (Weizmann)SLCO4A1
Ensembl hg19 (Hinxton)ENSG00000101187 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101187 [Gene_View]  ENSG00000101187 [Sequence]  chr20:62642445-62672295 [Contig_View]  SLCO4A1 [Vega]
ICGC DataPortalENSG00000101187
TCGA cBioPortalSLCO4A1
AceView (NCBI)SLCO4A1
Genatlas (Paris)SLCO4A1
WikiGenes28231
SOURCE (Princeton)SLCO4A1
Genetics Home Reference (NIH)SLCO4A1
Genomic and cartography
GoldenPath hg38 (UCSC)SLCO4A1  -     chr20:62642445-62672295 +  20q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLCO4A1  -     20q13.33   [Description]    (hg19-Feb_2009)
EnsemblSLCO4A1 - 20q13.33 [CytoView hg19]  SLCO4A1 - 20q13.33 [CytoView hg38]
Mapping of homologs : NCBISLCO4A1 [Mapview hg19]  SLCO4A1 [Mapview hg38]
OMIM612436   
Gene and transcription
Genbank (Entrez)AB031051 AF104334 AF187817 AF205072 AI660559
RefSeq transcript (Entrez)NM_016354
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLCO4A1
Cluster EST : UnigeneHs.235782 [ NCBI ]
CGAP (NCI)Hs.235782
Alternative Splicing GalleryENSG00000101187
Gene ExpressionSLCO4A1 [ NCBI-GEO ]   SLCO4A1 [ EBI - ARRAY_EXPRESS ]   SLCO4A1 [ SEEK ]   SLCO4A1 [ MEM ]
Gene Expression Viewer (FireBrowse)SLCO4A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)28231
GTEX Portal (Tissue expression)SLCO4A1
Human Protein AtlasENSG00000101187-SLCO4A1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96BD0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96BD0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96BD0
Splice isoforms : SwissVarQ96BD0
PhosPhoSitePlusQ96BD0
Domaine pattern : Prosite (Expaxy)KAZAL_2 (PS51465)    MFS (PS50850)   
Domains : Interpro (EBI)Kazal_dom    Kazal_dom_sf    MFS_dom    MFS_trans_sf    OATP   
Domain families : Pfam (Sanger)Kazal_2 (PF07648)    OATP (PF03137)   
Domain families : Pfam (NCBI)pfam07648    pfam03137   
Conserved Domain (NCBI)SLCO4A1
DMDM Disease mutations28231
Blocks (Seattle)SLCO4A1
SuperfamilyQ96BD0
Human Protein Atlas [tissue]ENSG00000101187-SLCO4A1 [tissue]
Peptide AtlasQ96BD0
HPRD11582
IPIIPI00100858   IPI00039680   IPI00218821   IPI00873199   IPI00218822   IPI00952591   IPI00884175   IPI00979491   
Protein Interaction databases
DIP (DOE-UCLA)Q96BD0
IntAct (EBI)Q96BD0
FunCoupENSG00000101187
BioGRIDSLCO4A1
STRING (EMBL)SLCO4A1
ZODIACSLCO4A1
Ontologies - Pathways
QuickGOQ96BD0
Ontology : AmiGOplasma membrane  integral component of plasma membrane  sodium-independent organic anion transmembrane transporter activity  thyroid hormone transmembrane transporter activity  thyroid hormone transmembrane transporter activity  sodium-independent organic anion transport  sodium-independent organic anion transport  transmembrane transport  thyroid hormone transport  
Ontology : EGO-EBIplasma membrane  integral component of plasma membrane  sodium-independent organic anion transmembrane transporter activity  thyroid hormone transmembrane transporter activity  thyroid hormone transmembrane transporter activity  sodium-independent organic anion transport  sodium-independent organic anion transport  transmembrane transport  thyroid hormone transport  
NDEx NetworkSLCO4A1
Atlas of Cancer Signalling NetworkSLCO4A1
Wikipedia pathwaysSLCO4A1
Orthology - Evolution
OrthoDB28231
GeneTree (enSembl)ENSG00000101187
Phylogenetic Trees/Animal Genes : TreeFamSLCO4A1
HOVERGENQ96BD0
HOGENOMQ96BD0
Homologs : HomoloGeneSLCO4A1
Homology/Alignments : Family Browser (UCSC)SLCO4A1
Gene fusions - Rearrangements
Fusion : MitelmanB4GALNT3/SLCO4A1 [12p13.33/20q13.33]  [t(12;20)(p13;q13)]  
Fusion PortalB4GALNT3 12p13.33 SLCO4A1 20q13.33 BRCA
Fusion : QuiverSLCO4A1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLCO4A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLCO4A1
dbVarSLCO4A1
ClinVarSLCO4A1
1000_GenomesSLCO4A1 
Exome Variant ServerSLCO4A1
ExAC (Exome Aggregation Consortium)ENSG00000101187
GNOMAD BrowserENSG00000101187
Varsome BrowserSLCO4A1
Genetic variants : HAPMAP28231
Genomic Variants (DGV)SLCO4A1 [DGVbeta]
DECIPHERSLCO4A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLCO4A1 
Mutations
ICGC Data PortalSLCO4A1 
TCGA Data PortalSLCO4A1 
Broad Tumor PortalSLCO4A1
OASIS PortalSLCO4A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLCO4A1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLCO4A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLCO4A1
DgiDB (Drug Gene Interaction Database)SLCO4A1
DoCM (Curated mutations)SLCO4A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLCO4A1 (select a term)
intoGenSLCO4A1
Cancer3DSLCO4A1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612436   
Orphanet
DisGeNETSLCO4A1
MedgenSLCO4A1
Genetic Testing Registry SLCO4A1
NextProtQ96BD0 [Medical]
TSGene28231
GENETestsSLCO4A1
Target ValidationSLCO4A1
Huge Navigator SLCO4A1 [HugePedia]
snp3D : Map Gene to Disease28231
BioCentury BCIQSLCO4A1
ClinGenSLCO4A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD28231
Chemical/Pharm GKB GenePA35838
Clinical trialSLCO4A1
Miscellaneous
canSAR (ICR)SLCO4A1 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLCO4A1
EVEXSLCO4A1
GoPubMedSLCO4A1
iHOPSLCO4A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:40:21 CET 2018
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