SLCO4C1 (solute carrier organic anion transporter family member 4C1)

2014-11-01  

Identity

HGNC
LOCATION
5q21.1
LOCUSID
ALIAS
OATP-H,OATP-M1,OATP4C1,OATPX,PRO2176,SLC21A20

Other Information

Locus ID:

NCBI: 353189
MIM: 609013
HGNC: 23612
Ensembl: ENSG00000173930

Variants:

dbSNP: 353189
ClinVar: 353189
TCGA: ENSG00000173930
COSMIC: SLCO4C1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173930ENST00000310954Q6ZQN7

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of organic anionsREACTOMER-HSA-879518
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
191972492009Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain.17
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
206914132010Genetic variation in solute carrier genes is associated with preeclampsia.4
149936042004Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.0
198758112009SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation.0
206108912010Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1.0
312888502019SLCO4C1 promoter methylation is a potential biomarker for prognosis associated with biochemical recurrence-free survival after radical prostatectomy.0

Citation

Dessen P

SLCO4C1 (solute carrier organic anion transporter family member 4C1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73508/slco4c1