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SLF1 (SMC5-SMC6 complex localization factor 1)

Identity

Alias_namesBRCTD1
ANKRD32
BRCT domain containing 1
ankyrin repeat domain 32
Alias_symbol (synonym)DKFZp761C121
DKFZp564C0469
BRCTx
Other alias
HGNC (Hugo) SLF1
LocusID (NCBI) 84250
Atlas_Id 55434
Location 5q15  [Link to chromosome band 5q15]
Location_base_pair Starts at 94618686 and ends at 94695868 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SLF1 (5q15) / SLF1 (5q15)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLF1   25408
Cards
Entrez_Gene (NCBI)SLF1  84250  SMC5-SMC6 complex localization factor 1
AliasesANKRD32; BRCTD1; BRCTx
GeneCards (Weizmann)SLF1
Ensembl hg19 (Hinxton)ENSG00000133302 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133302 [Gene_View]  chr5:94618686-94695868 [Contig_View]  SLF1 [Vega]
ICGC DataPortalENSG00000133302
TCGA cBioPortalSLF1
AceView (NCBI)SLF1
Genatlas (Paris)SLF1
WikiGenes84250
SOURCE (Princeton)SLF1
Genetics Home Reference (NIH)SLF1
Genomic and cartography
GoldenPath hg38 (UCSC)SLF1  -     chr5:94618686-94695868 +  5q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLF1  -     5q15   [Description]    (hg19-Feb_2009)
EnsemblSLF1 - 5q15 [CytoView hg19]  SLF1 - 5q15 [CytoView hg38]
Mapping of homologs : NCBISLF1 [Mapview hg19]  SLF1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK297452 AK299080 AK309859 AL050298 AL136560
RefSeq transcript (Entrez)NM_032290
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLF1
Cluster EST : UnigeneHs.657315 [ NCBI ]
CGAP (NCI)Hs.657315
Alternative Splicing GalleryENSG00000133302
Gene ExpressionSLF1 [ NCBI-GEO ]   SLF1 [ EBI - ARRAY_EXPRESS ]   SLF1 [ SEEK ]   SLF1 [ MEM ]
Gene Expression Viewer (FireBrowse)SLF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84250
GTEX Portal (Tissue expression)SLF1
Human Protein AtlasENSG00000133302-SLF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQI6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BQI6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQI6
Splice isoforms : SwissVarQ9BQI6
PhosPhoSitePlusQ9BQI6
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    BRCT_dom   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    RTT107_BRCT_5 (PF16770)   
Domain families : Pfam (NCBI)pfam12796    pfam16770   
Domain families : Smart (EMBL)ANK (SM00248)  BRCT (SM00292)  
Conserved Domain (NCBI)SLF1
DMDM Disease mutations84250
Blocks (Seattle)SLF1
SuperfamilyQ9BQI6
Human Protein Atlas [tissue]ENSG00000133302-SLF1 [tissue]
Peptide AtlasQ9BQI6
HPRD08538
IPIIPI00419518   IPI00908334   IPI00967130   IPI00977527   
Protein Interaction databases
DIP (DOE-UCLA)Q9BQI6
IntAct (EBI)Q9BQI6
FunCoupENSG00000133302
BioGRIDSLF1
STRING (EMBL)SLF1
ZODIACSLF1
Ontologies - Pathways
QuickGOQ9BQI6
Ontology : AmiGOnucleosome  protein binding  nucleus  nucleus  cytoplasm  centrosome  DNA repair  cellular response to DNA damage stimulus  positive regulation of protein complex assembly  ubiquitin protein ligase binding  protein complex binding  positive regulation of maintenance of mitotic sister chromatid cohesion  site of double-strand break  nuclear inclusion body  protein localization to site of double-strand break  positive regulation of double-strand break repair  
Ontology : EGO-EBInucleosome  protein binding  nucleus  nucleus  cytoplasm  centrosome  DNA repair  cellular response to DNA damage stimulus  positive regulation of protein complex assembly  ubiquitin protein ligase binding  protein complex binding  positive regulation of maintenance of mitotic sister chromatid cohesion  site of double-strand break  nuclear inclusion body  protein localization to site of double-strand break  positive regulation of double-strand break repair  
NDEx NetworkSLF1
Atlas of Cancer Signalling NetworkSLF1
Wikipedia pathwaysSLF1
Orthology - Evolution
OrthoDB84250
GeneTree (enSembl)ENSG00000133302
Phylogenetic Trees/Animal Genes : TreeFamSLF1
HOVERGENQ9BQI6
HOGENOMQ9BQI6
Homologs : HomoloGeneSLF1
Homology/Alignments : Family Browser (UCSC)SLF1
Gene fusions - Rearrangements
Tumor Fusion PortalSLF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLF1
dbVarSLF1
ClinVarSLF1
1000_GenomesSLF1 
Exome Variant ServerSLF1
ExAC (Exome Aggregation Consortium)ENSG00000133302
GNOMAD BrowserENSG00000133302
Genetic variants : HAPMAP84250
Genomic Variants (DGV)SLF1 [DGVbeta]
DECIPHERSLF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLF1 
Mutations
ICGC Data PortalSLF1 
TCGA Data PortalSLF1 
Broad Tumor PortalSLF1
OASIS PortalSLF1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDSLF1
BioMutasearch SLF1
DgiDB (Drug Gene Interaction Database)SLF1
DoCM (Curated mutations)SLF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLF1 (select a term)
intoGenSLF1
Cancer3DSLF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETSLF1
MedgenSLF1
Genetic Testing Registry SLF1
NextProtQ9BQI6 [Medical]
TSGene84250
GENETestsSLF1
Target ValidationSLF1
Huge Navigator SLF1 [HugePedia]
snp3D : Map Gene to Disease84250
BioCentury BCIQSLF1
ClinGenSLF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84250
Chemical/Pharm GKB GenePA134911523
Clinical trialSLF1
Miscellaneous
canSAR (ICR)SLF1 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLF1
EVEXSLF1
GoPubMedSLF1
iHOPSLF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:35:28 CET 2017

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