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SLF2 (SMC5-SMC6 complex localization factor 2)

Identity

Alias (NCBI)C10orf6
FAM178A
HGNC (Hugo) SLF2
HGNC Alias symbFLJ10512
FLJ25012
HGNC Previous nameC10orf6
 FAM178A
HGNC Previous namechromosome 10 open reading frame 6
 family with sequence similarity 178, member A
LocusID (NCBI) 55719
Atlas_Id 55451
Location 10q24.31  [Link to chromosome band 10q24]
Location_base_pair Starts at 100912963 and ends at 100965134 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SLF2   17814
Cards
Entrez_Gene (NCBI)SLF2    SMC5-SMC6 complex localization factor 2
AliasesC10orf6; FAM178A
GeneCards (Weizmann)SLF2
Ensembl hg19 (Hinxton)ENSG00000119906 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119906 [Gene_View]  ENSG00000119906 [Sequence]  chr10:100912963-100965134 [Contig_View]  SLF2 [Vega]
ICGC DataPortalENSG00000119906
TCGA cBioPortalSLF2
AceView (NCBI)SLF2
Genatlas (Paris)SLF2
SOURCE (Princeton)SLF2
Genetics Home Reference (NIH)SLF2
Genomic and cartography
GoldenPath hg38 (UCSC)SLF2  -     chr10:100912963-100965134 +  10q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLF2  -     10q24.31   [Description]    (hg19-Feb_2009)
GoldenPathSLF2 - 10q24.31 [CytoView hg19]  SLF2 - 10q24.31 [CytoView hg38]
ImmunoBaseENSG00000119906
Genome Data Viewer NCBISLF2 [Mapview hg19]  
OMIM610348   
Gene and transcription
Genbank (Entrez)AA829402 AF460991 AF460992 AI282394 AK001374
RefSeq transcript (Entrez)NM_001136123 NM_001243770 NM_018121 NM_144592
Consensus coding sequences : CCDS (NCBI)SLF2
Gene ExpressionSLF2 [ NCBI-GEO ]   SLF2 [ EBI - ARRAY_EXPRESS ]   SLF2 [ SEEK ]   SLF2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLF2 [ Firebrowse - Broad ]
GenevisibleExpression of SLF2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55719
GTEX Portal (Tissue expression)SLF2
Human Protein AtlasENSG00000119906-SLF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IX21   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IX21  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IX21
PhosPhoSitePlusQ8IX21
Domains : Interpro (EBI)FAM178   
Domain families : Pfam (Sanger)FAM178 (PF14816)   
Domain families : Pfam (NCBI)pfam14816   
Conserved Domain (NCBI)SLF2
SuperfamilyQ8IX21
AlphaFold pdb e-kbQ8IX21   
Human Protein Atlas [tissue]ENSG00000119906-SLF2 [tissue]
HPRD12581
Protein Interaction databases
DIP (DOE-UCLA)Q8IX21
IntAct (EBI)Q8IX21
BioGRIDSLF2
STRING (EMBL)SLF2
ZODIACSLF2
Ontologies - Pathways
QuickGOQ8IX21
Ontology : AmiGOchromatin  protein binding  nucleus  nucleus  nucleoplasm  DNA repair  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  positive regulation of protein-containing complex assembly  ubiquitin protein ligase binding  positive regulation of maintenance of mitotic sister chromatid cohesion  site of double-strand break  site of double-strand break  intracellular membrane-bounded organelle  protein-containing complex binding  protein localization to site of double-strand break  protein localization to site of double-strand break  positive regulation of double-strand break repair  positive regulation of double-strand break repair  
Ontology : EGO-EBIchromatin  protein binding  nucleus  nucleus  nucleoplasm  DNA repair  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  positive regulation of protein-containing complex assembly  ubiquitin protein ligase binding  positive regulation of maintenance of mitotic sister chromatid cohesion  site of double-strand break  site of double-strand break  intracellular membrane-bounded organelle  protein-containing complex binding  protein localization to site of double-strand break  protein localization to site of double-strand break  positive regulation of double-strand break repair  positive regulation of double-strand break repair  
NDEx NetworkSLF2
Atlas of Cancer Signalling NetworkSLF2
Wikipedia pathwaysSLF2
Orthology - Evolution
OrthoDB55719
GeneTree (enSembl)ENSG00000119906
Phylogenetic Trees/Animal Genes : TreeFamSLF2
Homologs : HomoloGeneSLF2
Homology/Alignments : Family Browser (UCSC)SLF2
Gene fusions - Rearrangements
Fusion : QuiverSLF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLF2
dbVarSLF2
ClinVarSLF2
MonarchSLF2
1000_GenomesSLF2 
Exome Variant ServerSLF2
GNOMAD BrowserENSG00000119906
Varsome BrowserSLF2
ACMGSLF2 variants
VarityQ8IX21
Genomic Variants (DGV)SLF2 [DGVbeta]
DECIPHERSLF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLF2 
Mutations
ICGC Data PortalSLF2 
TCGA Data PortalSLF2 
Broad Tumor PortalSLF2
OASIS PortalSLF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSLF2
Mutations and Diseases : HGMDSLF2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSLF2
DgiDB (Drug Gene Interaction Database)SLF2
DoCM (Curated mutations)SLF2
CIViC (Clinical Interpretations of Variants in Cancer)SLF2
Cancer3DSLF2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610348   
Orphanet
DisGeNETSLF2
MedgenSLF2
Genetic Testing Registry SLF2
NextProtQ8IX21 [Medical]
GENETestsSLF2
Target ValidationSLF2
Huge Navigator SLF2 [HugePedia]
ClinGenSLF2
Clinical trials, drugs, therapy
MyCancerGenomeSLF2
Protein Interactions : CTDSLF2
Pharm GKB GenePA162387411
PharosQ8IX21
Clinical trialSLF2
Miscellaneous
canSAR (ICR)SLF2
HarmonizomeSLF2
DataMed IndexSLF2
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSLF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:04 CEST 2021

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