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SLF2 (SMC5-SMC6 complex localization factor 2)

Identity

Alias_namesC10orf6
FAM178A
chromosome 10 open reading frame 6
family with sequence similarity 178, member A
Alias_symbol (synonym)FLJ10512
FLJ25012
Other alias
HGNC (Hugo) SLF2
LocusID (NCBI) 55719
Atlas_Id 55451
Location 10q24.31  [Link to chromosome band 10q24]
Location_base_pair Starts at 100912569 and ends at 100959590 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLF2   17814
Cards
Entrez_Gene (NCBI)SLF2  55719  SMC5-SMC6 complex localization factor 2
AliasesC10orf6; FAM178A
GeneCards (Weizmann)SLF2
Ensembl hg19 (Hinxton)ENSG00000119906 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119906 [Gene_View]  chr10:100912569-100959590 [Contig_View]  SLF2 [Vega]
ICGC DataPortalENSG00000119906
TCGA cBioPortalSLF2
AceView (NCBI)SLF2
Genatlas (Paris)SLF2
WikiGenes55719
SOURCE (Princeton)SLF2
Genetics Home Reference (NIH)SLF2
Genomic and cartography
GoldenPath hg38 (UCSC)SLF2  -     chr10:100912569-100959590 +  10q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLF2  -     10q24.31   [Description]    (hg19-Feb_2009)
EnsemblSLF2 - 10q24.31 [CytoView hg19]  SLF2 - 10q24.31 [CytoView hg38]
Mapping of homologs : NCBISLF2 [Mapview hg19]  SLF2 [Mapview hg38]
OMIM610348   
Gene and transcription
Genbank (Entrez)AA829402 AF460991 AF460992 AI282394 AK001374
RefSeq transcript (Entrez)NM_001136123 NM_001243770 NM_018121 NM_144592
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLF2
Cluster EST : UnigeneHs.732620 [ NCBI ]
CGAP (NCI)Hs.732620
Alternative Splicing GalleryENSG00000119906
Gene ExpressionSLF2 [ NCBI-GEO ]   SLF2 [ EBI - ARRAY_EXPRESS ]   SLF2 [ SEEK ]   SLF2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55719
GTEX Portal (Tissue expression)SLF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IX21   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IX21  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IX21
Splice isoforms : SwissVarQ8IX21
PhosPhoSitePlusQ8IX21
Domains : Interpro (EBI)FAM178   
Domain families : Pfam (Sanger)FAM178 (PF14816)   
Domain families : Pfam (NCBI)pfam14816   
Conserved Domain (NCBI)SLF2
DMDM Disease mutations55719
Blocks (Seattle)SLF2
SuperfamilyQ8IX21
Human Protein AtlasENSG00000119906
Peptide AtlasQ8IX21
HPRD12581
IPIIPI00293188   IPI00430796   IPI00816832   IPI00980301   IPI00640126   IPI00065348   
Protein Interaction databases
DIP (DOE-UCLA)Q8IX21
IntAct (EBI)Q8IX21
FunCoupENSG00000119906
BioGRIDSLF2
STRING (EMBL)SLF2
ZODIACSLF2
Ontologies - Pathways
QuickGOQ8IX21
Ontology : AmiGOchromatin  protein binding  extracellular space  nucleus  DNA repair  cellular response to DNA damage stimulus  positive regulation of protein complex assembly  ubiquitin protein ligase binding  protein complex binding  positive regulation of maintenance of mitotic sister chromatid cohesion  site of double-strand break  intracellular membrane-bounded organelle  protein localization to site of double-strand break  positive regulation of double-strand break repair  
Ontology : EGO-EBIchromatin  protein binding  extracellular space  nucleus  DNA repair  cellular response to DNA damage stimulus  positive regulation of protein complex assembly  ubiquitin protein ligase binding  protein complex binding  positive regulation of maintenance of mitotic sister chromatid cohesion  site of double-strand break  intracellular membrane-bounded organelle  protein localization to site of double-strand break  positive regulation of double-strand break repair  
NDEx NetworkSLF2
Atlas of Cancer Signalling NetworkSLF2
Wikipedia pathwaysSLF2
Orthology - Evolution
OrthoDB55719
GeneTree (enSembl)ENSG00000119906
Phylogenetic Trees/Animal Genes : TreeFamSLF2
HOVERGENQ8IX21
HOGENOMQ8IX21
Homologs : HomoloGeneSLF2
Homology/Alignments : Family Browser (UCSC)SLF2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLF2
dbVarSLF2
ClinVarSLF2
1000_GenomesSLF2 
Exome Variant ServerSLF2
ExAC (Exome Aggregation Consortium)SLF2 (select the gene name)
Genetic variants : HAPMAP55719
Genomic Variants (DGV)SLF2 [DGVbeta]
DECIPHERSLF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLF2 
Mutations
ICGC Data PortalSLF2 
TCGA Data PortalSLF2 
Broad Tumor PortalSLF2
OASIS PortalSLF2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDSLF2
BioMutasearch SLF2
DgiDB (Drug Gene Interaction Database)SLF2
DoCM (Curated mutations)SLF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLF2 (select a term)
intoGenSLF2
Cancer3DSLF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610348   
Orphanet
MedgenSLF2
Genetic Testing Registry SLF2
NextProtQ8IX21 [Medical]
TSGene55719
GENETestsSLF2
Target ValidationSLF2
Huge Navigator SLF2 [HugePedia]
snp3D : Map Gene to Disease55719
BioCentury BCIQSLF2
ClinGenSLF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55719
Chemical/Pharm GKB GenePA162387411
Clinical trialSLF2
Miscellaneous
canSAR (ICR)SLF2 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLF2
EVEXSLF2
GoPubMedSLF2
iHOPSLF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:31:57 CEST 2017

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