Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SLFN11 (schlafen family member 11)

Identity

Alias (NCBI)SLFN8/9
HGNC (Hugo) SLFN11
HGNC Alias symbFLJ34922
LocusID (NCBI) 91607
Atlas_Id 53135
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 35350310 and ends at 35373621 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SLFN11 (17q12) / CPE (4q32.3)SLFN11 (17q12) / MIEN1 (17q12)SLFN11 17q12 C17orf37

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SLFN11   26633
Cards
Entrez_Gene (NCBI)SLFN11    schlafen family member 11
AliasesSLFN8/9
GeneCards (Weizmann)SLFN11
Ensembl hg19 (Hinxton)ENSG00000172716 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172716 [Gene_View]  ENSG00000172716 [Sequence]  chr17:35350310-35373621 [Contig_View]  SLFN11 [Vega]
ICGC DataPortalENSG00000172716
TCGA cBioPortalSLFN11
AceView (NCBI)SLFN11
Genatlas (Paris)SLFN11
SOURCE (Princeton)SLFN11
Genetics Home Reference (NIH)SLFN11
Genomic and cartography
GoldenPath hg38 (UCSC)SLFN11  -     chr17:35350310-35373621 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLFN11  -     17q12   [Description]    (hg19-Feb_2009)
GoldenPathSLFN11 - 17q12 [CytoView hg19]  SLFN11 - 17q12 [CytoView hg38]
ImmunoBaseENSG00000172716
Genome Data Viewer NCBISLFN11 [Mapview hg19]  
OMIM614953   
Gene and transcription
Genbank (Entrez)AK074184 AK092241 AL512731 AL831964 BC052586
RefSeq transcript (Entrez)NM_001104587 NM_001104588 NM_001104589 NM_001104590 NM_001376007 NM_001376008 NM_001376009 NM_001376010 NM_001376011 NM_001376012 NM_001387158 NM_001387159 NM_001387160 NM_001387161 NM_001387162 NM_001387163 NM_152270
Consensus coding sequences : CCDS (NCBI)SLFN11
Gene ExpressionSLFN11 [ NCBI-GEO ]   SLFN11 [ EBI - ARRAY_EXPRESS ]   SLFN11 [ SEEK ]   SLFN11 [ MEM ]
Gene Expression Viewer (FireBrowse)SLFN11 [ Firebrowse - Broad ]
GenevisibleExpression of SLFN11 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91607
GTEX Portal (Tissue expression)SLFN11
Human Protein AtlasENSG00000172716-SLFN11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z7L1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z7L1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z7L1
PhosPhoSitePlusQ7Z7L1
Domains : Interpro (EBI)DUF2075    P-loop_NTPase    Schlafen    Schlafen_AlbA_2_dom    Schlafen_AlbA_2_dom_sf   
Domain families : Pfam (Sanger)AlbA_2 (PF04326)    DUF2075 (PF09848)   
Domain families : Pfam (NCBI)pfam04326    pfam09848   
Conserved Domain (NCBI)SLFN11
SuperfamilyQ7Z7L1
AlphaFold pdb e-kbQ7Z7L1   
Human Protein Atlas [tissue]ENSG00000172716-SLFN11 [tissue]
HPRD08178
Protein Interaction databases
DIP (DOE-UCLA)Q7Z7L1
IntAct (EBI)Q7Z7L1
BioGRIDSLFN11
STRING (EMBL)SLFN11
ZODIACSLFN11
Ontologies - Pathways
QuickGOQ7Z7L1
Ontology : AmiGOtRNA binding  tRNA binding  helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  cellular response to DNA damage stimulus  negative regulation of DNA replication  positive regulation of cell death  replication fork arrest  defense response to virus  defense response to virus  site of DNA damage  ATP hydrolysis activity  negative regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBItRNA binding  tRNA binding  helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  cellular response to DNA damage stimulus  negative regulation of DNA replication  positive regulation of cell death  replication fork arrest  defense response to virus  defense response to virus  site of DNA damage  ATP hydrolysis activity  negative regulation of G1/S transition of mitotic cell cycle  
NDEx NetworkSLFN11
Atlas of Cancer Signalling NetworkSLFN11
Wikipedia pathwaysSLFN11
Orthology - Evolution
OrthoDB91607
GeneTree (enSembl)ENSG00000172716
Phylogenetic Trees/Animal Genes : TreeFamSLFN11
Homologs : HomoloGeneSLFN11
Homology/Alignments : Family Browser (UCSC)SLFN11
Gene fusions - Rearrangements
Fusion : QuiverSLFN11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLFN11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLFN11
dbVarSLFN11
ClinVarSLFN11
MonarchSLFN11
1000_GenomesSLFN11 
Exome Variant ServerSLFN11
GNOMAD BrowserENSG00000172716
Varsome BrowserSLFN11
ACMGSLFN11 variants
VarityQ7Z7L1
Genomic Variants (DGV)SLFN11 [DGVbeta]
DECIPHERSLFN11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLFN11 
Mutations
ICGC Data PortalSLFN11 
TCGA Data PortalSLFN11 
Broad Tumor PortalSLFN11
OASIS PortalSLFN11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLFN11  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSLFN11
Mutations and Diseases : HGMDSLFN11
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSLFN11
DgiDB (Drug Gene Interaction Database)SLFN11
DoCM (Curated mutations)SLFN11
CIViC (Clinical Interpretations of Variants in Cancer)SLFN11
Cancer3DSLFN11
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614953   
Orphanet
DisGeNETSLFN11
MedgenSLFN11
Genetic Testing Registry SLFN11
NextProtQ7Z7L1 [Medical]
GENETestsSLFN11
Target ValidationSLFN11
Huge Navigator SLFN11 [HugePedia]
ClinGenSLFN11
Clinical trials, drugs, therapy
MyCancerGenomeSLFN11
Protein Interactions : CTDSLFN11
Pharm GKB GenePA144596358
PharosQ7Z7L1
Clinical trialSLFN11
Miscellaneous
canSAR (ICR)SLFN11
HarmonizomeSLFN11
DataMed IndexSLFN11
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSLFN11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:32:04 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.