SLFN11 (schlafen family member 11)

2013-01-01  

Identity

HGNC
SLFN11
LOCATION
17q12
LOCUSID
91607
ALIAS
SLFN8/9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 91607
MIM: 614953
HGNC: 26633
Ensembl: ENSG00000172716

Variants:

dbSNP: 91607
ClinVar: 91607
TCGA: ENSG00000172716
COSMIC: SLFN11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172716ENST00000308377Q7Z7L1
ENSG00000172716ENST00000394566Q7Z7L1
ENSG00000172716ENST00000427966C9JDG6
ENSG00000172716ENST00000430814C9J902
ENSG00000172716ENST00000441608C9JUT2
ENSG00000172716ENST00000588579K7ES87
ENSG00000172716ENST00000589811K7ER38
ENSG00000172716ENST00000591682K7EIM3
ENSG00000172716ENST00000592108K7EJJ3
ENSG00000172716ENST00000592122K7EKT7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA150481186topoisomerase I inhibitorsChemicalMultilinkAnnotationassociated26555224
PA445597Sarcoma, Ewing'sDiseaseMultilinkAnnotationassociated26555224

References

Pubmed IDYearTitleCitations
230009002012Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11.115
229274172012Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents.78
281965962017Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis.77
274402692017PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer.53
266583302016SLFN11 inhibits checkpoint maintenance and homologous recombination repair.36
266252112016Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs.31
293950612018SLFN11 Blocks Stressed Replication Forks Independently of ATR.31
257799422015SLFN11 Is a Transcriptional Target of EWS-FLI1 and a Determinant of Drug Response in Ewing Sarcoma.29
265257412015High SLFN11 expression predicts better survival for patients with KRAS exon 2 wild type colorectal cancer after treated with adjuvant oxaliplatin-based treatment.11
284036292017Methylation of SLFN11 is a marker of poor prognosis and cisplatin resistance in colorectal cancer.11

Citation

Dessen P

SLFN11 (schlafen family member 11)

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/gene/53135/slfn11