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SLIT1 (slit guidance ligand 1)

Identity

Alias (NCBI)MEGF4
SLIL1
SLIT-1
SLIT3
HGNC (Hugo) SLIT1
HGNC Alias symbMEGF4
Slit-1
SLIT3
HGNC Previous nameSLIL1
HGNC Previous nameslit (Drosophila) homolog 1
 slit homolog 1 (Drosophila)
LocusID (NCBI) 6585
Atlas_Id 50488
Location 10q24.1  [Link to chromosome band 10q24]
Location_base_pair Starts at 96998038 and ends at 97185959 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PKD1 (16p13.3) / SLIT1 (10q24.1)SLIT1 (10q24.1) / FAM208B (10p15.1)SLIT1 (10q24.1) / RAB10 (2p23.3)
SLIT1 (10q24.1) / SFRP5 (10q24.2)TM9SF3 (10q24.1) / SLIT1 (10q24.1)SLIT1 10q24.1 / SFRP5 10q24.2
TM9SF3 10q24.1 / SLIT1 10q24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SLIT1   11085
Cards
Entrez_Gene (NCBI)SLIT1    slit guidance ligand 1
AliasesMEGF4; SLIL1; SLIT-1; SLIT3
GeneCards (Weizmann)SLIT1
Ensembl hg19 (Hinxton)ENSG00000187122 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187122 [Gene_View]  ENSG00000187122 [Sequence]  chr10:96998038-97185959 [Contig_View]  SLIT1 [Vega]
ICGC DataPortalENSG00000187122
TCGA cBioPortalSLIT1
AceView (NCBI)SLIT1
Genatlas (Paris)SLIT1
SOURCE (Princeton)SLIT1
Genetics Home Reference (NIH)SLIT1
Genomic and cartography
GoldenPath hg38 (UCSC)SLIT1  -     chr10:96998038-97185959 -  10q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLIT1  -     10q24.1   [Description]    (hg19-Feb_2009)
GoldenPathSLIT1 - 10q24.1 [CytoView hg19]  SLIT1 - 10q24.1 [CytoView hg38]
ImmunoBaseENSG00000187122
Genome Data Viewer NCBISLIT1 [Mapview hg19]  
OMIM603742   
Gene and transcription
Genbank (Entrez)AB011537 AB017167 AY029183 BC028105 BC139909
RefSeq transcript (Entrez)NM_003061
Consensus coding sequences : CCDS (NCBI)SLIT1
Gene ExpressionSLIT1 [ NCBI-GEO ]   SLIT1 [ EBI - ARRAY_EXPRESS ]   SLIT1 [ SEEK ]   SLIT1 [ MEM ]
Gene Expression Viewer (FireBrowse)SLIT1 [ Firebrowse - Broad ]
GenevisibleExpression of SLIT1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6585
GTEX Portal (Tissue expression)SLIT1
Human Protein AtlasENSG00000187122-SLIT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75093   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75093  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75093
PhosPhoSitePlusO75093
Domaine pattern : Prosite (Expaxy)CTCK_1 (PS01185)    CTCK_2 (PS01225)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    LAM_G_DOMAIN (PS50025)    LRR (PS51450)   
Domains : Interpro (EBI)ConA-like_dom_sf    Cys-rich_flank_reg_C    Cys_knot_C    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Fol_N    Growth_fac_rcpt_cys_sf    Laminin_G    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_dom_sf    LRRNT   
Domain families : Pfam (Sanger)EGF (PF00008)    hEGF (PF12661)    Laminin_G_2 (PF02210)    LRR_8 (PF13855)    LRRCT (PF01463)    LRRNT (PF01462)   
Domain families : Pfam (NCBI)pfam00008    pfam12661    pfam02210    pfam13855    pfam01463    pfam01462   
Domain families : Smart (EMBL)CT (SM00041)  EGF (SM00181)  EGF_CA (SM00179)  FOLN (SM00274)  LamG (SM00282)  LRR_TYP (SM00369)  LRRCT (SM00082)  LRRNT (SM00013)  
Conserved Domain (NCBI)SLIT1
SuperfamilyO75093
AlphaFold pdb e-kbO75093   
Human Protein Atlas [tissue]ENSG00000187122-SLIT1 [tissue]
HPRD04773
Protein Interaction databases
DIP (DOE-UCLA)O75093
IntAct (EBI)O75093
BioGRIDSLIT1
STRING (EMBL)SLIT1
ZODIACSLIT1
Ontologies - Pathways
QuickGOO75093
Ontology : AmiGOcalcium ion binding  protein binding  extracellular space  extracellular space  nuclear migration  axon guidance  axon guidance  motor neuron axon guidance  heparin binding  chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration  retinal ganglion cell axon guidance  dorsal/ventral axon guidance  Roundabout binding  Roundabout binding  axon extension involved in axon guidance  forebrain morphogenesis  negative chemotaxis  negative chemotaxis  negative regulation of synapse assembly  
Ontology : EGO-EBIcalcium ion binding  protein binding  extracellular space  extracellular space  nuclear migration  axon guidance  axon guidance  motor neuron axon guidance  heparin binding  chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration  retinal ganglion cell axon guidance  dorsal/ventral axon guidance  Roundabout binding  Roundabout binding  axon extension involved in axon guidance  forebrain morphogenesis  negative chemotaxis  negative chemotaxis  negative regulation of synapse assembly  
Pathways : KEGGAxon guidance   
NDEx NetworkSLIT1
Atlas of Cancer Signalling NetworkSLIT1
Wikipedia pathwaysSLIT1
Orthology - Evolution
OrthoDB6585
GeneTree (enSembl)ENSG00000187122
Phylogenetic Trees/Animal Genes : TreeFamSLIT1
Homologs : HomoloGeneSLIT1
Homology/Alignments : Family Browser (UCSC)SLIT1
Gene fusions - Rearrangements
Fusion : MitelmanPKD1/SLIT1 [16p13.3/10q24.1]  
Fusion : MitelmanSLIT1/SFRP5 [10q24.1/10q24.2]  
Fusion : MitelmanTM9SF3/SLIT1 [10q24.1/10q24.1]  
Fusion : QuiverSLIT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLIT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLIT1
dbVarSLIT1
ClinVarSLIT1
MonarchSLIT1
1000_GenomesSLIT1 
Exome Variant ServerSLIT1
GNOMAD BrowserENSG00000187122
Varsome BrowserSLIT1
ACMGSLIT1 variants
VarityO75093
Genomic Variants (DGV)SLIT1 [DGVbeta]
DECIPHERSLIT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLIT1 
Mutations
ICGC Data PortalSLIT1 
TCGA Data PortalSLIT1 
Broad Tumor PortalSLIT1
OASIS PortalSLIT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLIT1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSLIT1
Mutations and Diseases : HGMDSLIT1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSLIT1
DgiDB (Drug Gene Interaction Database)SLIT1
DoCM (Curated mutations)SLIT1
CIViC (Clinical Interpretations of Variants in Cancer)SLIT1
Cancer3DSLIT1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603742   
Orphanet
DisGeNETSLIT1
MedgenSLIT1
Genetic Testing Registry SLIT1
NextProtO75093 [Medical]
GENETestsSLIT1
Target ValidationSLIT1
Huge Navigator SLIT1 [HugePedia]
ClinGenSLIT1
Clinical trials, drugs, therapy
MyCancerGenomeSLIT1
Protein Interactions : CTDSLIT1
Pharm GKB GenePA35938
PharosO75093
Clinical trialSLIT1
Miscellaneous
canSAR (ICR)SLIT1
HarmonizomeSLIT1
DataMed IndexSLIT1
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSLIT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:05 CEST 2021

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