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SLITRK2 (SLIT and NTRK like family member 2)

Identity

Alias (NCBI)CXorf1
CXorf2
SLITL1
TMEM257
HGNC (Hugo) SLITRK2
HGNC Previous nameCXorf1
HGNC Previous namechromosome X open reading frame 1
LocusID (NCBI) 84631
Atlas_Id 74923
Location Xq27.3  [Link to chromosome band Xq27]
Location_base_pair Starts at 145817829 and ends at 145829852 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SLITRK2 (Xq27.3) / SLITRK2 (Xq27.3)SRSF5 (14q24.2) / SLITRK2 (Xq27.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SLITRK2   13449
Cards
Entrez_Gene (NCBI)SLITRK2    SLIT and NTRK like family member 2
AliasesCXorf1; CXorf2; SLITL1; TMEM257
GeneCards (Weizmann)SLITRK2
Ensembl hg19 (Hinxton)ENSG00000185985 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185985 [Gene_View]  ENSG00000185985 [Sequence]  chrX:145817829-145829852 [Contig_View]  SLITRK2 [Vega]
ICGC DataPortalENSG00000185985
TCGA cBioPortalSLITRK2
AceView (NCBI)SLITRK2
Genatlas (Paris)SLITRK2
SOURCE (Princeton)SLITRK2
Genetics Home Reference (NIH)SLITRK2
Genomic and cartography
GoldenPath hg38 (UCSC)SLITRK2  -     chrX:145817829-145829852 +  Xq27.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLITRK2  -     Xq27.3   [Description]    (hg19-Feb_2009)
GoldenPathSLITRK2 - Xq27.3 [CytoView hg19]  SLITRK2 - Xq27.3 [CytoView hg38]
ImmunoBaseENSG00000185985
Genome Data Viewer NCBISLITRK2 [Mapview hg19]  
OMIM300561   
Gene and transcription
Genbank (Entrez)AB058757 AF007148 AK091015 AK096278 AK289732
RefSeq transcript (Entrez)NM_001144003 NM_001144004 NM_001144005 NM_001144006 NM_001144007 NM_001144008 NM_001144009 NM_001144010 NM_032539
Consensus coding sequences : CCDS (NCBI)SLITRK2
Gene ExpressionSLITRK2 [ NCBI-GEO ]   SLITRK2 [ EBI - ARRAY_EXPRESS ]   SLITRK2 [ SEEK ]   SLITRK2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLITRK2 [ Firebrowse - Broad ]
GenevisibleExpression of SLITRK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84631
GTEX Portal (Tissue expression)SLITRK2
Human Protein AtlasENSG00000185985-SLITRK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H156   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H156  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H156
PhosPhoSitePlusQ9H156
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_dom_sf    LRRNT    Slitrk   
Domain families : Pfam (Sanger)LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam13855   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRCT (SM00082)  LRRNT (SM00013)  
Conserved Domain (NCBI)SLITRK2
SuperfamilyQ9H156
AlphaFold pdb e-kbQ9H156   
Human Protein Atlas [tissue]ENSG00000185985-SLITRK2 [tissue]
HPRD06477
Protein Interaction databases
DIP (DOE-UCLA)Q9H156
IntAct (EBI)Q9H156
BioGRIDSLITRK2
STRING (EMBL)SLITRK2
ZODIACSLITRK2
Ontologies - Pathways
QuickGOQ9H156
Ontology : AmiGOplasma membrane  axonogenesis  regulation of synapse organization  regulation of synapse organization  positive regulation of synapse assembly  glutamatergic synapse  glutamatergic synapse  GABA-ergic synapse  GABA-ergic synapse  integral component of postsynaptic membrane  synaptic membrane adhesion  synaptic membrane adhesion  regulation of presynapse assembly  regulation of presynapse assembly  
Ontology : EGO-EBIplasma membrane  axonogenesis  regulation of synapse organization  regulation of synapse organization  positive regulation of synapse assembly  glutamatergic synapse  glutamatergic synapse  GABA-ergic synapse  GABA-ergic synapse  integral component of postsynaptic membrane  synaptic membrane adhesion  synaptic membrane adhesion  regulation of presynapse assembly  regulation of presynapse assembly  
NDEx NetworkSLITRK2
Atlas of Cancer Signalling NetworkSLITRK2
Wikipedia pathwaysSLITRK2
Orthology - Evolution
OrthoDB84631
GeneTree (enSembl)ENSG00000185985
Phylogenetic Trees/Animal Genes : TreeFamSLITRK2
Homologs : HomoloGeneSLITRK2
Homology/Alignments : Family Browser (UCSC)SLITRK2
Gene fusions - Rearrangements
Fusion : QuiverSLITRK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLITRK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLITRK2
dbVarSLITRK2
ClinVarSLITRK2
MonarchSLITRK2
1000_GenomesSLITRK2 
Exome Variant ServerSLITRK2
GNOMAD BrowserENSG00000185985
Varsome BrowserSLITRK2
ACMGSLITRK2 variants
VarityQ9H156
Genomic Variants (DGV)SLITRK2 [DGVbeta]
DECIPHERSLITRK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLITRK2 
Mutations
ICGC Data PortalSLITRK2 
TCGA Data PortalSLITRK2 
Broad Tumor PortalSLITRK2
OASIS PortalSLITRK2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDSLITRK2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSLITRK2
DgiDB (Drug Gene Interaction Database)SLITRK2
DoCM (Curated mutations)SLITRK2
CIViC (Clinical Interpretations of Variants in Cancer)SLITRK2
Cancer3DSLITRK2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300561   
Orphanet
DisGeNETSLITRK2
MedgenSLITRK2
Genetic Testing Registry SLITRK2
NextProtQ9H156 [Medical]
GENETestsSLITRK2
Target ValidationSLITRK2
Huge Navigator SLITRK2 [HugePedia]
ClinGenSLITRK2
Clinical trials, drugs, therapy
MyCancerGenomeSLITRK2
Protein Interactions : CTDSLITRK2
Pharm GKB GenePA134968225
PharosQ9H156
Clinical trialSLITRK2
Miscellaneous
canSAR (ICR)SLITRK2
HarmonizomeSLITRK2
DataMed IndexSLITRK2
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSLITRK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:21:18 CEST 2021

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