SLK (STE20 like kinase)

2004-04-01  

Identity

HGNC
LOCATION
10q24.33
LOCUSID
ALIAS
LOSK,STK2,bA16H23.1,se20-9
FUSION GENES

Other Information

Locus ID:

NCBI: 9748
MIM: 616563
HGNC: 11088
Ensembl: ENSG00000065613

Variants:

dbSNP: 9748
ClinVar: 9748
TCGA: ENSG00000065613
COSMIC: SLK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065613ENST00000335753Q9H2G2
ENSG00000065613ENST00000369755Q9H2G2

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
249587722014SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation.30
232093042012Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.29
173216102007Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform.13
182875412008Ste20-related protein kinase LOSK (SLK) controls microtubule radial array in interphase.13
168374602006v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II.11
195259802009The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility.11
239853222013Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome.7
260947692015Identification of Tpr and α-actinin-4 as two novel SLK-interacting proteins.2
295345782018Ste20-like kinase is upregulated in glioma and induces glioma invasion.0

Citation

Dessen P

SLK (STE20 like kinase)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/42329/slk