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SLK (STE20 like kinase)

Identity

Alias_namesSNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase (yeast)
STE20-like kinase (yeast)
STE20-like kinase
Alias_symbol (synonym)STK2
se20-9
KIAA0204
Other aliasLOSK
bA16H23.1
HGNC (Hugo) SLK
LocusID (NCBI) 9748
Atlas_Id 42329
Location 10q24.33  [Link to chromosome band 10q24]
Location_base_pair Starts at 103967185 and ends at 104029233 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SLK (10q24.33) / DNAH5 (5p15.2)SLK (10q24.33) / ZFHX3 (16q22.2)SLK 10q24.33 / ZFHX3 16q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLK   11088
Cards
Entrez_Gene (NCBI)SLK  9748  STE20 like kinase
AliasesLOSK; STK2; bA16H23.1; se20-9
GeneCards (Weizmann)SLK
Ensembl hg19 (Hinxton)ENSG00000065613 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000065613 [Gene_View]  chr10:103967185-104029233 [Contig_View]  SLK [Vega]
ICGC DataPortalENSG00000065613
TCGA cBioPortalSLK
AceView (NCBI)SLK
Genatlas (Paris)SLK
WikiGenes9748
SOURCE (Princeton)SLK
Genetics Home Reference (NIH)SLK
Genomic and cartography
GoldenPath hg38 (UCSC)SLK  -     chr10:103967185-104029233 +  10q24.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLK  -     10q24.33   [Description]    (hg19-Feb_2009)
EnsemblSLK - 10q24.33 [CytoView hg19]  SLK - 10q24.33 [CytoView hg38]
Mapping of homologs : NCBISLK [Mapview hg19]  SLK [Mapview hg38]
OMIM616563   
Gene and transcription
Genbank (Entrez)AB002804 AF273048 AK302855 AK307389 BC008697
RefSeq transcript (Entrez)NM_001304743 NM_014720
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLK
Cluster EST : UnigeneHs.591922 [ NCBI ]
CGAP (NCI)Hs.591922
Alternative Splicing GalleryENSG00000065613
Gene ExpressionSLK [ NCBI-GEO ]   SLK [ EBI - ARRAY_EXPRESS ]   SLK [ SEEK ]   SLK [ MEM ]
Gene Expression Viewer (FireBrowse)SLK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9748
GTEX Portal (Tissue expression)SLK
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H2G2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H2G2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H2G2
Splice isoforms : SwissVarQ9H2G2
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9H2G2
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    UVR (PS50151)   
Domains : Interpro (EBI)Kinase-like_dom    PKK    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    UVR_dom   
Domain families : Pfam (Sanger)Pkinase (PF00069)    PKK (PF12474)   
Domain families : Pfam (NCBI)pfam00069    pfam12474   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)SLK
DMDM Disease mutations9748
Blocks (Seattle)SLK
PDB (SRS)2J51    2JFL    2JFM    2UV2    4USF   
PDB (PDBSum)2J51    2JFL    2JFM    2UV2    4USF   
PDB (IMB)2J51    2JFL    2JFM    2UV2    4USF   
PDB (RSDB)2J51    2JFL    2JFM    2UV2    4USF   
Structural Biology KnowledgeBase2J51    2JFL    2JFM    2UV2    4USF   
SCOP (Structural Classification of Proteins)2J51    2JFL    2JFM    2UV2    4USF   
CATH (Classification of proteins structures)2J51    2JFL    2JFM    2UV2    4USF   
SuperfamilyQ9H2G2
Human Protein AtlasENSG00000065613
Peptide AtlasQ9H2G2
HPRD11585
IPIIPI00022827   IPI00247439   
Protein Interaction databases
DIP (DOE-UCLA)Q9H2G2
IntAct (EBI)Q9H2G2
FunCoupENSG00000065613
BioGRIDSLK
STRING (EMBL)SLK
ZODIACSLK
Ontologies - Pathways
QuickGOQ9H2G2
Ontology : AmiGOprotein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  apoptotic process  signal transduction by protein phosphorylation  regulation of cell migration  regulation of cell migration  cytoplasmic microtubule organization  cell leading edge  identical protein binding  protein homodimerization activity  regulation of apoptotic process  cadherin binding  protein autophosphorylation  perinuclear region of cytoplasm  regulation of focal adhesion assembly  extracellular exosome  
Ontology : EGO-EBIprotein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  apoptotic process  signal transduction by protein phosphorylation  regulation of cell migration  regulation of cell migration  cytoplasmic microtubule organization  cell leading edge  identical protein binding  protein homodimerization activity  regulation of apoptotic process  cadherin binding  protein autophosphorylation  perinuclear region of cytoplasm  regulation of focal adhesion assembly  extracellular exosome  
Pathways : KEGGOocyte meiosis   
NDEx NetworkSLK
Atlas of Cancer Signalling NetworkSLK
Wikipedia pathwaysSLK
Orthology - Evolution
OrthoDB9748
GeneTree (enSembl)ENSG00000065613
Phylogenetic Trees/Animal Genes : TreeFamSLK
HOVERGENQ9H2G2
HOGENOMQ9H2G2
Homologs : HomoloGeneSLK
Homology/Alignments : Family Browser (UCSC)SLK
Gene fusions - Rearrangements
Fusion : MitelmanSLK/ZFHX3 [10q24.33/16q22.2]  
Fusion: TCGASLK 10q24.33 ZFHX3 16q22.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLK
dbVarSLK
ClinVarSLK
1000_GenomesSLK 
Exome Variant ServerSLK
ExAC (Exome Aggregation Consortium)SLK (select the gene name)
Genetic variants : HAPMAP9748
Genomic Variants (DGV)SLK [DGVbeta]
DECIPHERSLK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLK 
Mutations
ICGC Data PortalSLK 
TCGA Data PortalSLK 
Broad Tumor PortalSLK
OASIS PortalSLK [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDSLK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLK
DgiDB (Drug Gene Interaction Database)SLK
DoCM (Curated mutations)SLK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLK (select a term)
intoGenSLK
Cancer3DSLK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616563   
Orphanet
MedgenSLK
Genetic Testing Registry SLK
NextProtQ9H2G2 [Medical]
TSGene9748
GENETestsSLK
Target ValidationSLK
Huge Navigator SLK [HugePedia]
snp3D : Map Gene to Disease9748
BioCentury BCIQSLK
ClinGenSLK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9748
Chemical/Pharm GKB GenePA35941
Clinical trialSLK
Miscellaneous
canSAR (ICR)SLK (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLK
EVEXSLK
GoPubMedSLK
iHOPSLK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:56:25 CEST 2017

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