Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SLX1A (SLX1 homolog A, structure-specific endonuclease subunit)

Identity

Alias_namesGIYD1
GIY-YIG domain containing 1
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
Other alias
HGNC (Hugo) SLX1A
LocusID (NCBI) 548593
Atlas_Id 51670
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 29454501 and ends at 29458224 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLX1A   20922
Cards
Entrez_Gene (NCBI)SLX1A  548593  SLX1 homolog A, structure-specific endonuclease subunit
AliasesGIYD1
GeneCards (Weizmann)SLX1A
Ensembl hg19 (Hinxton)ENSG00000132207 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132207 [Gene_View]  chr16:29454501-29458224 [Contig_View]  SLX1A [Vega]
ICGC DataPortalENSG00000132207
TCGA cBioPortalSLX1A
AceView (NCBI)SLX1A
Genatlas (Paris)SLX1A
WikiGenes548593
SOURCE (Princeton)SLX1A
Genetics Home Reference (NIH)SLX1A
Genomic and cartography
GoldenPath hg38 (UCSC)SLX1A  -     chr16:29454501-29458224 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLX1A  -     16p11.2   [Description]    (hg19-Feb_2009)
EnsemblSLX1A - 16p11.2 [CytoView hg19]  SLX1A - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBISLX1A [Mapview hg19]  SLX1A [Mapview hg38]
OMIM615822   
Gene and transcription
Genbank (Entrez)AI885276 BC141497 BC144462 BC148777 BI757439
RefSeq transcript (Entrez)NM_001014999 NM_001015000
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLX1A
Cluster EST : UnigeneHs.729791 [ NCBI ]
CGAP (NCI)Hs.729791
Alternative Splicing GalleryENSG00000132207
Gene ExpressionSLX1A [ NCBI-GEO ]   SLX1A [ EBI - ARRAY_EXPRESS ]   SLX1A [ SEEK ]   SLX1A [ MEM ]
Gene Expression Viewer (FireBrowse)SLX1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)548593
GTEX Portal (Tissue expression)SLX1A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQ83   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BQ83  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQ83
Splice isoforms : SwissVarQ9BQ83
PhosPhoSitePlusQ9BQ83
Domaine pattern : Prosite (Expaxy)GIY_YIG (PS50164)   
Domains : Interpro (EBI)GIY-YIG_SF    Slx1   
Domain families : Pfam (Sanger)GIY-YIG (PF01541)   
Domain families : Pfam (NCBI)pfam01541   
Conserved Domain (NCBI)SLX1A
DMDM Disease mutations548593
Blocks (Seattle)SLX1A
SuperfamilyQ9BQ83
Human Protein AtlasENSG00000132207
Peptide AtlasQ9BQ83
HPRD18681
IPIIPI00031535   IPI00376968   IPI00386111   
Protein Interaction databases
DIP (DOE-UCLA)Q9BQ83
IntAct (EBI)Q9BQ83
FunCoupENSG00000132207
BioGRIDSLX1A
STRING (EMBL)SLX1A
ZODIACSLX1A
Ontologies - Pathways
QuickGOQ9BQ83
Ontology : AmiGOdouble-strand break repair via homologous recombination  endodeoxyribonuclease activity  protein binding  nucleoplasm  nucleoplasm  DNA repair  crossover junction endodeoxyribonuclease activity  DNA double-strand break processing involved in repair via single-strand annealing  telomere maintenance via telomere lengthening  5'-flap endonuclease activity  Slx1-Slx4 complex  Slx1-Slx4 complex  interstrand cross-link repair  metal ion binding  telomeric D-loop disassembly  nucleic acid phosphodiester bond hydrolysis  t-circle formation  t-circle formation  negative regulation of telomere maintenance via telomere lengthening  positive regulation of t-circle formation  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  endodeoxyribonuclease activity  protein binding  nucleoplasm  nucleoplasm  DNA repair  crossover junction endodeoxyribonuclease activity  DNA double-strand break processing involved in repair via single-strand annealing  telomere maintenance via telomere lengthening  5'-flap endonuclease activity  Slx1-Slx4 complex  Slx1-Slx4 complex  interstrand cross-link repair  metal ion binding  telomeric D-loop disassembly  nucleic acid phosphodiester bond hydrolysis  t-circle formation  t-circle formation  negative regulation of telomere maintenance via telomere lengthening  positive regulation of t-circle formation  
Pathways : KEGGFanconi anemia pathway   
NDEx NetworkSLX1A
Atlas of Cancer Signalling NetworkSLX1A
Wikipedia pathwaysSLX1A
Orthology - Evolution
OrthoDB548593
GeneTree (enSembl)ENSG00000132207
Phylogenetic Trees/Animal Genes : TreeFamSLX1A
HOVERGENQ9BQ83
HOGENOMQ9BQ83
Homologs : HomoloGeneSLX1A
Homology/Alignments : Family Browser (UCSC)SLX1A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLX1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLX1A
dbVarSLX1A
ClinVarSLX1A
1000_GenomesSLX1A 
Exome Variant ServerSLX1A
ExAC (Exome Aggregation Consortium)SLX1A (select the gene name)
Genetic variants : HAPMAP548593
Genomic Variants (DGV)SLX1A [DGVbeta]
DECIPHERSLX1A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLX1A 
Mutations
ICGC Data PortalSLX1A 
TCGA Data PortalSLX1A 
Broad Tumor PortalSLX1A
OASIS PortalSLX1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLX1A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLX1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLX1A
DgiDB (Drug Gene Interaction Database)SLX1A
DoCM (Curated mutations)SLX1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLX1A (select a term)
intoGenSLX1A
Cancer3DSLX1A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615822   
Orphanet
MedgenSLX1A
Genetic Testing Registry SLX1A
NextProtQ9BQ83 [Medical]
TSGene548593
GENETestsSLX1A
Target ValidationSLX1A
Huge Navigator SLX1A [HugePedia]
snp3D : Map Gene to Disease548593
BioCentury BCIQSLX1A
ClinGenSLX1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD548593
Chemical/Pharm GKB GenePA142671737
Clinical trialSLX1A
Miscellaneous
canSAR (ICR)SLX1A (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLX1A
EVEXSLX1A
GoPubMedSLX1A
iHOPSLX1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:56:26 CEST 2017

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