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SLX4 (SLX4 structure-specific endonuclease subunit)

Identity

Other namesBTBD12
FANCP
MUS312
HGNC (Hugo) SLX4
LocusID (NCBI) 84464
Location 16p13.3
Location_base_pair Starts at 3631184 and ends at 3661585 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)SLX4   23845
Cards
Entrez_Gene (NCBI)SLX4  84464  SLX4 structure-specific endonuclease subunit
GeneCards (Weizmann)SLX4
Ensembl (Hinxton)ENSG00000188827 [Gene_View]  chr16:3631184-3661585 [Contig_View]  SLX4 [Vega]
AceView (NCBI)SLX4
Genatlas (Paris)SLX4
WikiGenes84464
SOURCE (Princeton)NM_032444
Genomic and cartography
GoldenPath (UCSC)SLX4  -  16p13.3   chr16:3631184-3661585 -  16p13.3   [Description]    (hg19-Feb_2009)
EnsemblSLX4 - 16p13.3 [CytoView]
Mapping of homologs : NCBISLX4 [Mapview]
OMIM613278   613951   
Gene and transcription
Genbank (Entrez)AB058687 AB075867 AK095411 AK122775 AL442083
RefSeq transcript (Entrez)NM_032444
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NG_028123 NT_010393 NW_001838341 NW_004929400
Consensus coding sequences : CCDS (NCBI)SLX4
Cluster EST : UnigeneHs.143681 [ NCBI ]
CGAP (NCI)Hs.143681
Alternative Splicing : Fast-db (Paris)GSHG0033882
Alternative Splicing GalleryENSG00000188827
Gene ExpressionSLX4 [ NCBI-GEO ]     SLX4 [ SEEK ]   SLX4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IY92 (Uniprot)
NextProtQ8IY92  [Medical]
With graphics : InterProQ8IY92
Splice isoforms : SwissVarQ8IY92 (Swissvar)
Domaine pattern : Prosite (Expaxy)BTB (PS50097)   
Domains : Interpro (EBI)BTB/POZ-like    BTB/POZ_fold    BTB_POZ    Structure-sp_endonuc_su_Slx4   
Related proteins : CluSTrQ8IY92
Domain families : Pfam (Sanger)BTB (PF00651)    Slx4 (PF09494)   
Domain families : Pfam (NCBI)pfam00651    pfam09494   
Domain families : Smart (EMBL)BTB (SM00225)  
DMDM Disease mutations84464
Blocks (Seattle)Q8IY92
Human Protein AtlasENSG00000188827
Peptide AtlasQ8IY92
HPRD12537
IPIIPI00291796   IPI00412364   
Protein Interaction databases
DIP (DOE-UCLA)Q8IY92
IntAct (EBI)Q8IY92
FunCoupENSG00000188827
BioGRIDSLX4
InParanoidQ8IY92
Interologous Interaction database Q8IY92
IntegromeDBSLX4
STRING (EMBL)SLX4
Ontologies - Pathways
Ontology : AmiGOdouble-strand break repair via homologous recombination  nuclear chromosome, telomeric region  nuclear chromatin  protein binding  DNA replication  DNA repair  nucleotide-excision repair  enzyme activator activity  crossover junction endodeoxyribonuclease activity  DNA double-strand break processing involved in repair via single-strand annealing  5'-flap endonuclease activity  Slx1-Slx4 complex  positive regulation of catalytic activity  3'-flap endonuclease activity  Holliday junction resolvase complex  ERCC4-ERCC1 complex  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  nuclear chromosome, telomeric region  nuclear chromatin  protein binding  DNA replication  DNA repair  nucleotide-excision repair  enzyme activator activity  crossover junction endodeoxyribonuclease activity  DNA double-strand break processing involved in repair via single-strand annealing  5'-flap endonuclease activity  Slx1-Slx4 complex  positive regulation of catalytic activity  3'-flap endonuclease activity  Holliday junction resolvase complex  ERCC4-ERCC1 complex  
Pathways : KEGGFanconi anemia pathway   
REACTOMESLX4
Protein Interaction DatabaseSLX4
Wikipedia pathwaysSLX4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SLX4
SNP (GeneSNP Utah)SLX4
SNP : HGBaseSLX4
Genetic variants : HAPMAPSLX4
1000_GenomesSLX4 
ICGC programENSG00000188827 
Somatic Mutations in Cancer : COSMICSLX4 
CONAN: Copy Number AnalysisSLX4 
Mutations and Diseases : HGMDSLX4
OMIM613278    613951   
GENETestsSLX4
Disease Genetic AssociationSLX4
Huge Navigator SLX4 [HugePedia]  SLX4 [HugeCancerGEM]
Genomic VariantsSLX4  SLX4 [DGVbeta]
Exome VariantSLX4
dbVarSLX4
ClinVarSLX4
snp3D : Map Gene to Disease84464
General knowledge
Homologs : HomoloGeneSLX4
Homology/Alignments : Family Browser (UCSC)SLX4
Phylogenetic Trees/Animal Genes : TreeFamSLX4
Chemical/Protein Interactions : CTD84464
Chemical/Pharm GKB GenePA134983583
Clinical trialSLX4
Cancer Resource (Charite)ENSG00000188827
Other databases
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
CoreMineSLX4
iHOPSLX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:03:24 CEST 2014

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