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SMAD3 (SMAD family member 3)

Identity

Alias (NCBI)HSPC193
HsT17436
JV15-2
LDS1C
LDS3
MADH3
HGNC (Hugo) SMAD3
HGNC Alias symbJV15-2
HsT17436
HGNC Previous nameMADH3
HGNC Previous nameMAD, mothers against decapentaplegic homolog 3 (Drosophila)
 SMAD, mothers against DPP homolog 3 (Drosophila)
LocusID (NCBI) 4088
Atlas_Id 41229
Location 15q22.33  [Link to chromosome band 15q22]
Location_base_pair Starts at 67065602 and ends at 67195167 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD74 (5q32) / SMAD3 (15q22.33)SMAD3 (15q22.33) / AAGAB (15q22.33)SMAD3 (15q22.33) / DIS3L (15q22.31)
SMAD3 (15q22.33) / EXOC4 (7q33)SMAD3 (15q22.33) / PHLDB1 (11q23.3)SMAD3 (15q22.33) / SENP8 (15q23)
SMAD3 (15q22.33) / SLC9A9 (3q24)SMAD3 (15q22.33) / SMAD3 (15q22.33)SMAD3 (15q22.33) / SMAD6 (15q22.31)
SMAD3 (15q22.33) / TACC1 (8p11.22)SMAD3 15q22.33 / DIS3L 15q22.31SMAD3 15q22.33 / SENP8 15q23
SMAD3 15q22.33 / SLC9A9 3q24SMAD3 15q22.33 / SMAD6 15q22.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 7 ]
  inv(3)(p24q26) ?/MECOM
inv(3)(q21q26) RPN1/MECOM
t(3;5)(q26;q31) H2AFY/MECOM
t(3;7)(q26;q21) CDK6/MECOM
t(3;21)(q26;q11) NRIP1/MECOM
t(9;10)(q34;q22) ZMIZ1/ABL1
t(11;19)(q13;p13) FSTL3/CCND1


External links

Nomenclature
HGNC (Hugo)SMAD3   6769
Cards
Entrez_Gene (NCBI)SMAD3    SMAD family member 3
AliasesHSPC193; HsT17436; JV15-2; LDS1C; 
LDS3; MADH3
GeneCards (Weizmann)SMAD3
Ensembl hg19 (Hinxton)ENSG00000166949 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166949 [Gene_View]  ENSG00000166949 [Sequence]  chr15:67065602-67195167 [Contig_View]  SMAD3 [Vega]
ICGC DataPortalENSG00000166949
TCGA cBioPortalSMAD3
AceView (NCBI)SMAD3
Genatlas (Paris)SMAD3
SOURCE (Princeton)SMAD3
Genetics Home Reference (NIH)SMAD3
Genomic and cartography
GoldenPath hg38 (UCSC)SMAD3  -     chr15:67065602-67195167 +  15q22.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SMAD3  -     15q22.33   [Description]    (hg19-Feb_2009)
GoldenPathSMAD3 - 15q22.33 [CytoView hg19]  SMAD3 - 15q22.33 [CytoView hg38]
ImmunoBaseENSG00000166949
Genome Data Viewer NCBISMAD3 [Mapview hg19]  
OMIM603109   613795   
Gene and transcription
Genbank (Entrez)AA493306 AB209616 AF151027 AI762628 AI991957
RefSeq transcript (Entrez)NM_001145102 NM_001145103 NM_001145104 NM_005902
Consensus coding sequences : CCDS (NCBI)SMAD3
Gene ExpressionSMAD3 [ NCBI-GEO ]   SMAD3 [ EBI - ARRAY_EXPRESS ]   SMAD3 [ SEEK ]   SMAD3 [ MEM ]
Gene Expression Viewer (FireBrowse)SMAD3 [ Firebrowse - Broad ]
GenevisibleExpression of SMAD3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4088
GTEX Portal (Tissue expression)SMAD3
Human Protein AtlasENSG00000166949-SMAD3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)SMAD3
Human Protein Atlas [tissue]ENSG00000166949-SMAD3 [tissue]
HPRD04380
Protein Interaction databases
BioGRIDSMAD3
STRING (EMBL)SMAD3
ZODIACSMAD3
Ontologies - Pathways
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSMAD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:32:07 CEST 2021

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