| Nomenclature | | HGNC (Hugo) | SMAD3 6769 |
| Entrez_Gene (NCBI) | SMAD3 4088 SMAD family member 3 |
| Cards | | GeneCards (Weizmann) | SMAD3 |
| Ensembl (Hinxton) | ENSG00000166949 [Gene_View] chr15:67418054-67487533 [Contig_View] SMAD3 [Vega] |
| AceView (NCBI) | SMAD3 |
| Genatlas (Paris) | SMAD3 |
| SOURCE (Stanford) | NM_001145102 NM_001145103 NM_001145104 NM_005902 |
| Genomic and cartography | | GoldenPath (UCSC) | SMAD3 - 15q22.33 chr15:67418054-67487533 + 15q22.33 [Description] (hg19-Feb_2009) |
| Ensembl | SMAD3 - 15q22.33 [CytoView] |
| Mapping of homologs : NCBI | SMAD3 [Mapview] |
| OMIM | 603109 613795 |
| Gene and transcription |
| Genbank (Entrez) | AA493306 AB209616 AF151027 AI762628 AI991957 |
| RefSeq transcript (SRS) | NM_001145102 NM_001145103 NM_001145104 NM_005902 |
| RefSeq transcript (Entrez) | NM_001145102 NM_001145103 NM_001145104 NM_005902 |
| RefSeq genomic (SRS) | AC_000147 NC_000015 NC_018926 NG_011990 NT_010194 NW_001838218 NW_004078084 |
| RefSeq genomic (Entrez) | AC_000147 NC_000015 NC_018926 NG_011990 NT_010194 NW_001838218 NW_004078084 |
| Consensus coding sequences : CCDS (NCBI) | SMAD3 |
| Cluster EST : Unigene | Hs.742270 [ SRS ] Hs.742270 [ NCBI ] |
| CGAP (NCI) | Hs.742270 |
| Alternative Splicing : Fast-db (Paris) | GSHG0009955 |
| Alternative Splicing Gallery | ENSG00000166949 |
| Gene Expression | SMAD3 [ NCBI-GEO ] SMAD3 [ EBI - ARRAY_EXPRESS ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P84022 (SRS) P84022 (Uniprot) |
| NextProt | P84022 |
| With graphics : InterPro | P84022 |
| Splice isoforms : SwissVar | P84022(Swissvar) |
| Domaine pattern : Prosite (SRS) | MH1 (PS51075) MH2 (PS51076) |
| Domaine pattern : Prosite (Expaxy) | MH1 (PS51075) MH2 (PS51076) |
| Domains : Interpro (SRS) | Dwarfin MAD_homology1_Dwarfin-type MAD_homology_MH1 SMAD_dom-like SMAD_dom_Dwarfin-type SMAD_FHA_domain |
| Domains : Interpro (EBI) | Dwarfin MAD_homology1_Dwarfin-type MAD_homology_MH1 SMAD_dom-like SMAD_dom_Dwarfin-type SMAD_FHA_domain |
| Related proteins : CluSTr | P84022 |
| Domain families : Pfam (SRS) | MH1 (PF03165) MH2 (PF03166) |
| Domain families : Pfam (Sanger) | MH1 (PF03165) MH2 (PF03166) |
| Domain families : Pfam (NCBI) | pfam03165 pfam03166 |
| Domain families : Smart (EMBL) | DWA (SM00523) DWB (SM00524) |
| DMDM | 4088 |
| Blocks (Seattle) | P84022 |
| PDB (SRS) | 1MHD 1MJS 1MK2 1OZJ 1U7F 2LAJ 2LB2 |
| PDB (PDBSum) | 1MHD 1MJS 1MK2 1OZJ 1U7F 2LAJ 2LB2 |
| PDB (IMB) | 1MHD 1MJS 1MK2 1OZJ 1U7F 2LAJ 2LB2 |
| PDB (RSDB) | 1MHD 1MJS 1MK2 1OZJ 1U7F 2LAJ 2LB2 |
| Human Protein Atlas | ENSG00000166949 |
| HPRD | 04380 |
| IPI | IPI00024305 IPI00383289 IPI00922059 IPI00922698 IPI00922049 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P84022 |
| IntAct (EBI) | P84022 |
| FunCoup | ENSG00000166949 |
| REACTOME | SMAD3 |
| Protein Interaction Database | 4088 |
| BioGRID | SMAD3 |
| InParanoid | P84022 |
| Interologous Interaction database | P84022 |
| IntegromeDB | SMAD3 |
| Polymorphism : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | SMAD3 |
| SNP (GeneSNP Utah) | SMAD3 |
| SNP : HGBase | SMAD3 |
| Genetic variants : HAPMAP | SMAD3 |
| Somatic Mutations in Cancer : COSMIC | SMAD3 |
| CONAN: Copy Number Analysis | SMAD3 |
| Mutations and Diseases : HGMD | SMAD3 |
| OMIM | 603109 613795 |
| GENETests | 603109 613795 |
| Disease Genetic Association | SMAD3 |
| Huge Navigator |
SMAD3 [HugePedia] SMAD3 [HugeCancerGEM] |
| Genomic Variants | SMAD3 SMAD3 [DGVbeta] |
| snp3D : Map Gene to Disease | 4088 |
| General knowledge |
|---|
| Homologs : HomoloGene | SMAD3 |
| Homology/Alignments : Family Browser (UCSC) | SMAD3 |
| Phylogenetic Trees/Animal Genes : TreeFam | SMAD3 |
| Chemical/Protein Interactions : CTD | 4088 |
| Chemical/Pharm GKB Gene | PA30526 |
| Clinical trial | SMAD3 |
| Cancer Resource (Charite) | ENSG00000166949 |
| Ontology : AmiGO | negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding protein binding transcription factor activity RNA polymerase II activating transcription factor binding ureteric bud development response to hypoxia in utero embryonic development mesoderm formation somitogenesis release of cytochrome c from mitochondria liver development negative regulation of protein phosphorylation heart looping osteoblast development immune system development double-stranded DNA binding sequence-specific DNA binding transcription factor activity sequence-specific DNA binding transcription factor activity transforming growth factor beta receptor binding protein binding collagen binding nucleus nuclear inner membrane nucleoplasm transcription factor complex cytoplasm cytosol plasma membrane transcription, DNA-dependent transcription initiation from RNA polymerase II promoter transport induction of apoptosis activation of cysteine-type endopeptidase activity involved in apoptotic process immune response cell cycle arrest transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway SMAD protein complex assembly endoderm development beta-catenin binding transcription factor binding zinc ion binding embryonic pattern specification gene expression positive regulation of alkaline phosphatase activity positive regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition regulation of striated muscle tissue development regulation of transforming growth factor beta receptor signaling pathway evasion or tolerance of host defenses by virus protein kinase binding phosphatase binding negative regulation of cell growth positive regulation of cell migration positive regulation of bone mineralization negative regulation of transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity thyroid gland development primary miRNA processing chromatin DNA binding ubiquitin protein ligase binding positive regulation of chondrocyte differentiation positive regulation of interleukin-1 beta production regulation of transforming growth factor beta2 production positive regulation of transforming growth factor beta3 production activin receptor signaling pathway negative regulation of osteoblast proliferation positive regulation of catenin import into nucleus nodal signaling pathway wound healing T cell activation negative regulation of protein catabolic process protein homodimerization activity positive regulation of transcription factor import into nucleus negative regulation of apoptotic process ubiquitin binding receptor complex sequence-specific DNA binding transcription regulatory region DNA binding cell-cell junction organization negative regulation of osteoblast differentiation positive regulation of transcription, DNA-dependent negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter metal ion binding paraxial mesoderm morphogenesis developmental growth embryonic foregut morphogenesis embryonic cranial skeleton morphogenesis regulation of epithelial cell proliferation negative regulation of inflammatory response regulation of immune response protein stabilization positive regulation of positive chemotaxis regulation of binding positive regulation of stress fiber assembly positive regulation of focal adhesion assembly pericardium development transdifferentiation negative regulation of wound healing lens fiber cell differentiation co-SMAD binding R-SMAD binding SMAD protein complex positive regulation of canonical Wnt receptor signaling pathway positive regulation of gene expression involved in extracellular matrix organization |
| Ontology : EGO-EBI | negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding protein binding transcription factor activity RNA polymerase II activating transcription factor binding ureteric bud development response to hypoxia in utero embryonic development mesoderm formation somitogenesis release of cytochrome c from mitochondria liver development negative regulation of protein phosphorylation heart looping osteoblast development immune system development double-stranded DNA binding sequence-specific DNA binding transcription factor activity sequence-specific DNA binding transcription factor activity transforming growth factor beta receptor binding protein binding collagen binding nucleus nuclear inner membrane nucleoplasm transcription factor complex cytoplasm cytosol plasma membrane transcription, DNA-dependent transcription initiation from RNA polymerase II promoter transport induction of apoptosis activation of cysteine-type endopeptidase activity involved in apoptotic process immune response cell cycle arrest transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor signaling pathway SMAD protein complex assembly endoderm development beta-catenin binding transcription factor binding zinc ion binding embryonic pattern specification gene expression positive regulation of alkaline phosphatase activity positive regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition regulation of striated muscle tissue development regulation of transforming growth factor beta receptor signaling pathway evasion or tolerance of host defenses by virus protein kinase binding phosphatase binding negative regulation of cell growth positive regulation of cell migration positive regulation of bone mineralization negative regulation of transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity thyroid gland development primary miRNA processing chromatin DNA binding ubiquitin protein ligase binding positive regulation of chondrocyte differentiation positive regulation of interleukin-1 beta production regulation of transforming growth factor beta2 production positive regulation of transforming growth factor beta3 production activin receptor signaling pathway negative regulation of osteoblast proliferation positive regulation of catenin import into nucleus nodal signaling pathway wound healing T cell activation negative regulation of protein catabolic process protein homodimerization activity positive regulation of transcription factor import into nucleus negative regulation of apoptotic process ubiquitin binding receptor complex sequence-specific DNA binding transcription regulatory region DNA binding cell-cell junction organization negative regulation of osteoblast differentiation positive regulation of transcription, DNA-dependent negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter metal ion binding paraxial mesoderm morphogenesis developmental growth embryonic foregut morphogenesis embryonic cranial skeleton morphogenesis regulation of epithelial cell proliferation negative regulation of inflammatory response regulation of immune response protein stabilization positive regulation of positive chemotaxis regulation of binding positive regulation of stress fiber assembly positive regulation of focal adhesion assembly pericardium development transdifferentiation negative regulation of wound healing lens fiber cell differentiation co-SMAD binding R-SMAD binding SMAD protein complex positive regulation of canonical Wnt receptor signaling pathway positive regulation of gene expression involved in extracellular matrix organization |
| Pathways : BIOCARTA | Cell Cycle: G1/S Check Point [Genes] NFkB activation by Nontypeable Hemophilus influenzae [Genes] TGF beta signaling pathway [Genes] Role of Tob in T-cell activation [Genes] |
| Pathways : KEGG | Colorectal cancerAdherens junctionWnt signaling pathwayCell cycleTGF-beta signaling pathway |
| Other databases | | Probes |
|---|
| Litterature | | PubMed | 451 Pubmed reference(s) in Entrez |
| PubGene | SMAD3 |
| iHOP | SMAD3 |
