| FGFR1OP2 (12p11.23) / SMARCA2 (9p24.3) | GFM1 (3q25.32) / SMARCA2 (9p24.3) | KCNMA1 (10q22.3) / SMARCA2 (9p24.3) |
|
PVT1 (8q24.21) / SMARCA2 (9p24.3) | RFX3 (9p24.2) / SMARCA2 (9p24.3) | SMARCA2 (9p24.3) / AC074212.3 () |
|
SMARCA2 (9p24.3) / DMRT1 (9p24.3) | SMARCA2 (9p24.3) / SMARCA2 (9p24.3) | TMEM181 (6q25.3) / SMARCA2 (9p24.3) |
|
RFX3 9p24.2 / SMARCA2 9p24.3 | SMARCA2 9p24.3 AC074212.3 | SMARCA2 9p24.3 / DMRT1 9p24.3 |
|
| Nomenclature |
HGNC (Hugo) | SMARCA2 11098 |
LRG (Locus Reference Genomic) | LRG_882 |
| Cards |
Entrez_Gene (NCBI) | SMARCA2 6595 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
Aliases | BAF190; BRM; NCBRS; SNF2; |
| SNF2L2; SNF2LA; SWI2; Sth1p; hBRM; hSNF2a |
GeneCards (Weizmann) | SMARCA2 |
Ensembl hg19 (Hinxton) | ENSG00000080503 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000080503 [Gene_View]  ENSG00000080503 [Sequence] chr9:2015219-2193623 [Contig_View] SMARCA2 [Vega] |
ICGC DataPortal | ENSG00000080503 |
TCGA cBioPortal | SMARCA2 |
AceView (NCBI) | SMARCA2 |
Genatlas (Paris) | SMARCA2 |
WikiGenes | 6595 |
SOURCE (Princeton) | SMARCA2 |
Genetics Home Reference (NIH) | SMARCA2 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | SMARCA2 - chr9:2015219-2193623 + 9p24.3 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | SMARCA2 - 9p24.3 [Description] (hg19-Feb_2009) |
GoldenPath | SMARCA2 - 9p24.3 [CytoView hg19] SMARCA2 - 9p24.3 [CytoView hg38] |
ImmunoBase | ENSG00000080503 |
Mapping of homologs : NCBI | SMARCA2 [Mapview hg19] SMARCA2 [Mapview hg38] |
OMIM | 600014 601358 |
| Gene and transcription |
Genbank (Entrez) | AK094076 AK296373 AK298045 AK299683 AK300093 |
RefSeq transcript (Entrez) | NM_001289396 NM_001289397 NM_001289398 NM_001289399 NM_001289400 NM_003070 NM_139045 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | SMARCA2 |
Cluster EST : Unigene | Hs.644901 [ NCBI ] |
CGAP (NCI) | Hs.644901 |
Alternative Splicing Gallery | ENSG00000080503 |
Gene Expression | SMARCA2 [ NCBI-GEO ] SMARCA2 [ EBI - ARRAY_EXPRESS ]
SMARCA2 [ SEEK ] SMARCA2 [ MEM ] |
Gene Expression Viewer (FireBrowse) | SMARCA2 [ Firebrowse - Broad ] |
SOURCE (Princeton) | Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60] |
Genevestigator | Expression in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 6595 |
GTEX Portal (Tissue expression) | SMARCA2 |
Human Protein Atlas | ENSG00000080503-SMARCA2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | P51531 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | P51531 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | P51531 |
Splice isoforms : SwissVar | P51531 |
PhosPhoSitePlus | P51531 |
Domaine pattern : Prosite (Expaxy) | BROMODOMAIN_1 (PS00633) BROMODOMAIN_2 (PS50014) HELICASE_ATP_BIND_1 (PS51192) HELICASE_CTER (PS51194) HSA (PS51204) QLQ (PS51666) |
Domains : Interpro (EBI) | BRK_domain BRK_sf Bromodomain Bromodomain-like_sf Bromodomain_CS Gln-Leu-Gln_QLQ Helicase_ATP-bd Helicase_C HSA_dom P-loop_NTPase SMARCA2 SnAC SNF2-like_sf SNF2_N |
Domain families : Pfam (Sanger) | BRK (PF07533) Bromodomain (PF00439) Helicase_C (PF00271) HSA (PF07529) QLQ (PF08880) SnAC (PF14619) SNF2_N (PF00176) |
Domain families : Pfam (NCBI) | pfam07533 pfam00439 pfam00271 pfam07529 pfam08880 pfam14619 pfam00176 |
Domain families : Smart (EMBL) | BRK (SM00592) BROMO (SM00297) DEXDc (SM00487) HELICc (SM00490) HSA (SM00573) QLQ (SM00951) SnAC (SM01314) |
Conserved Domain (NCBI) | SMARCA2 |
DMDM Disease mutations | 6595 |
Blocks (Seattle) | SMARCA2 |
PDB (RSDB) | 2DAT 4QY4 5DKC 5DKH |
PDB Europe | 2DAT 4QY4 5DKC 5DKH |
PDB (PDBSum) | 2DAT 4QY4 5DKC 5DKH |
PDB (IMB) | 2DAT 4QY4 5DKC 5DKH |
Structural Biology KnowledgeBase | 2DAT 4QY4 5DKC 5DKH |
SCOP (Structural Classification of Proteins) | 2DAT 4QY4 5DKC 5DKH |
CATH (Classification of proteins structures) | 2DAT 4QY4 5DKC 5DKH |
Superfamily | P51531 |
Human Protein Atlas [tissue] | ENSG00000080503-SMARCA2 [tissue] |
Peptide Atlas | P51531 |
HPRD | 02483 |
IPI | IPI00514648 IPI00386718 IPI00647560 IPI00647028 IPI00641350 IPI00641050 IPI00640353 IPI00642503 IPI00103451 IPI00643691 IPI00640994 IPI00644329 IPI00645885 |
| Protein Interaction databases |
DIP (DOE-UCLA) | P51531 |
IntAct (EBI) | P51531 |
FunCoup | ENSG00000080503 |
BioGRID | SMARCA2 |
STRING (EMBL) | SMARCA2 |
ZODIAC | SMARCA2 |
| Ontologies - Pathways |
QuickGO | P51531 |
Ontology : AmiGO | negative regulation of transcription by RNA polymerase II nuclear chromatin DNA binding chromatin binding transcription coactivator activity helicase activity protein binding ATP binding nucleus nucleus nucleoplasm nucleoplasm chromatin remodeling chromatin remodeling regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II spermatid development nervous system development DNA-dependent ATPase activity DNA-dependent ATPase activity negative regulation of cell proliferation SWI/SNF complex negative regulation of cell growth histone binding ATP-dependent chromatin remodeling intracellular membrane-bounded organelle transcription regulatory region DNA binding intermediate filament cytoskeleton negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II npBAF complex nBAF complex |
Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II nuclear chromatin DNA binding chromatin binding transcription coactivator activity helicase activity protein binding ATP binding nucleus nucleus nucleoplasm nucleoplasm chromatin remodeling chromatin remodeling regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II spermatid development nervous system development DNA-dependent ATPase activity DNA-dependent ATPase activity negative regulation of cell proliferation SWI/SNF complex negative regulation of cell growth histone binding ATP-dependent chromatin remodeling intracellular membrane-bounded organelle transcription regulatory region DNA binding intermediate filament cytoskeleton negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II npBAF complex nBAF complex |
NDEx Network | SMARCA2 |
Atlas of Cancer Signalling Network | SMARCA2 |
Wikipedia pathways | SMARCA2 |
| Orthology - Evolution |
OrthoDB | 6595 |
GeneTree (enSembl) | ENSG00000080503 |
Phylogenetic Trees/Animal Genes : TreeFam | SMARCA2 |
HOGENOM | P51531 |
Homologs : HomoloGene | SMARCA2 |
Homology/Alignments : Family Browser (UCSC) | SMARCA2 |
| Gene fusions - Rearrangements |
Fusion : Mitelman | RFX3/SMARCA2 [9p24.2/9p24.3]  [t(9;9)(p24;p24)] |
Fusion : Mitelman | SMARCA2/DMRT1 [9p24.3/9p24.3]  [t(9;9)(p24;p24)] |
Fusion Portal | RFX3 9p24.2 SMARCA2 9p24.3 BRCA |
Fusion Portal | SMARCA2 9p24.3 AC074212.3 SKCM |
Fusion Portal | SMARCA2 9p24.3 DMRT1 9p24.3 HNSC |
Fusion : Quiver | SMARCA2 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | SMARCA2 [hg38] |
dbSNP Single Nucleotide Polymorphism (NCBI) | SMARCA2 |
dbVar | SMARCA2 |
ClinVar | SMARCA2 |
1000_Genomes | SMARCA2 |
Exome Variant Server | SMARCA2 |
ExAC (Exome Aggregation Consortium) | ENSG00000080503 |
GNOMAD Browser | ENSG00000080503 |
Varsome Browser | SMARCA2 |
Genetic variants : HAPMAP | 6595 |
Genomic Variants (DGV) | SMARCA2 [DGVbeta] |
DECIPHER | SMARCA2 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | SMARCA2 |
| Mutations |
ICGC Data Portal | SMARCA2 |
TCGA Data Portal | SMARCA2 |
Broad Tumor Portal | SMARCA2 |
OASIS Portal | SMARCA2 [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | SMARCA2 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | SMARCA2 |
Mutations and Diseases : HGMD | SMARCA2 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
BioMuta | search SMARCA2 |
DgiDB (Drug Gene Interaction Database) | SMARCA2 |
DoCM (Curated mutations) | SMARCA2 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | SMARCA2 (select a term) |
intoGen | SMARCA2 |
Cancer3D | SMARCA2(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 600014 601358 |
Orphanet | 3183 |
DisGeNET | SMARCA2 |
Medgen | SMARCA2 |
Genetic Testing Registry | SMARCA2
|
NextProt | P51531 [Medical] |
TSGene | 6595 |
GENETests | SMARCA2 |
Target Validation | SMARCA2 |
Huge Navigator |
SMARCA2 [HugePedia] |
snp3D : Map Gene to Disease | 6595 |
BioCentury BCIQ | SMARCA2 |
ClinGen | SMARCA2 (curated) |
| Clinical trials, drugs, therapy |
---|
Chemical/Protein Interactions : CTD | 6595 |
Chemical/Pharm GKB Gene | PA35948 |
Clinical trial | SMARCA2 |
| Miscellaneous |
---|
canSAR (ICR) | SMARCA2 (select the gene name) |
DataMed Index | SMARCA2 |
| Probes |
---|
| Litterature |
---|
PubMed | 211 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
CoreMine | SMARCA2 |
EVEX | SMARCA2 |
GoPubMed | SMARCA2 |
iHOP | SMARCA2 |