SMARCC1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1)

2007-04-01  

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
BAF155,CRACC1,Rsc8,SRG3,SWI3
FUSION GENES

Other Information

Locus ID:

NCBI: 6599
MIM: 601732
HGNC: 11104
Ensembl: ENSG00000173473

Variants:

dbSNP: 6599
ClinVar: 6599
TCGA: ENSG00000173473
COSMIC: SMARCC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173473ENST00000254480Q92922
ENSG00000173473ENST00000454240F8WE13

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
RMTs methylate histone argininesREACTOMER-HSA-3214858

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
244342082014CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
161998782005Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57.47
191561452009Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer.40
237998502013miR-320c regulates gemcitabine-resistance in pancreatic cancer via SMARCC1.32
221395742011Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene.24
208293582010Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex.19
185812782008SMARCC1 expression is upregulated in prostate cancer and positively correlated with tumour recurrence and dedifferentiation.14
193675812010Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.13
165680922006Members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt.9

Citation

Dessen P

SMARCC1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47173/smarcc1