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SMC4 (structural maintenance of chromosomes 4)

Identity

Alias_namesSMC4L1
SMC4 (structural maintenance of chromosomes 4, yeast)-like 1
SMC4 structural maintenance of chromosomes 4-like 1 (yeast)
Alias_symbol (synonym)hCAP-C
CAP-C
Other aliasCAPC
SMC-4
HGNC (Hugo) SMC4
LocusID (NCBI) 10051
Atlas_Id 49826
Location 3q25.33  [Link to chromosome band 3q25]
Location_base_pair Starts at 160399304 and ends at 160434961 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COL3A1 (2q32.2) / SMC4 (3q25.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SMC4   14013
Cards
Entrez_Gene (NCBI)SMC4  10051  structural maintenance of chromosomes 4
AliasesCAP-C; CAPC; SMC-4; SMC4L1
GeneCards (Weizmann)SMC4
Ensembl hg19 (Hinxton)ENSG00000113810 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113810 [Gene_View]  chr3:160399304-160434961 [Contig_View]  SMC4 [Vega]
ICGC DataPortalENSG00000113810
TCGA cBioPortalSMC4
AceView (NCBI)SMC4
Genatlas (Paris)SMC4
WikiGenes10051
SOURCE (Princeton)SMC4
Genetics Home Reference (NIH)SMC4
Genomic and cartography
GoldenPath hg38 (UCSC)SMC4  -     chr3:160399304-160434961 +  3q25.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SMC4  -     3q25.33   [Description]    (hg19-Feb_2009)
EnsemblSMC4 - 3q25.33 [CytoView hg19]  SMC4 - 3q25.33 [CytoView hg38]
Mapping of homologs : NCBISMC4 [Mapview hg19]  SMC4 [Mapview hg38]
OMIM605575   
Gene and transcription
Genbank (Entrez)AB019987 AF092564 AK002200 AK026361 AK122939
RefSeq transcript (Entrez)NM_001002799 NM_001002800 NM_001288753 NM_005496
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SMC4
Cluster EST : UnigeneHs.58992 [ NCBI ]
CGAP (NCI)Hs.58992
Alternative Splicing GalleryENSG00000113810
Gene ExpressionSMC4 [ NCBI-GEO ]   SMC4 [ EBI - ARRAY_EXPRESS ]   SMC4 [ SEEK ]   SMC4 [ MEM ]
Gene Expression Viewer (FireBrowse)SMC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10051
GTEX Portal (Tissue expression)SMC4
Human Protein AtlasENSG00000113810-SMC4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NTJ3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NTJ3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NTJ3
Splice isoforms : SwissVarQ9NTJ3
PhosPhoSitePlusQ9NTJ3
Domains : Interpro (EBI)P-loop_NTPase    RecF/RecN/SMC_N    SMC    SMC_hinge   
Domain families : Pfam (Sanger)SMC_hinge (PF06470)    SMC_N (PF02463)   
Domain families : Pfam (NCBI)pfam06470    pfam02463   
Domain families : Smart (EMBL)SMC_hinge (SM00968)  
Conserved Domain (NCBI)SMC4
DMDM Disease mutations10051
Blocks (Seattle)SMC4
PDB (SRS)4U4P   
PDB (PDBSum)4U4P   
PDB (IMB)4U4P   
PDB (RSDB)4U4P   
Structural Biology KnowledgeBase4U4P   
SCOP (Structural Classification of Proteins)4U4P   
CATH (Classification of proteins structures)4U4P   
SuperfamilyQ9NTJ3
Human Protein Atlas [tissue]ENSG00000113810-SMC4 [tissue]
Peptide AtlasQ9NTJ3
HPRD09276
IPIIPI00411559   IPI00328298   IPI00793575   IPI00945243   IPI00947372   IPI00947202   IPI00944900   IPI00945252   IPI00947558   IPI00946854   IPI00792419   
Protein Interaction databases
DIP (DOE-UCLA)Q9NTJ3
IntAct (EBI)Q9NTJ3
FunCoupENSG00000113810
BioGRIDSMC4
STRING (EMBL)SMC4
ZODIACSMC4
Ontologies - Pathways
QuickGOQ9NTJ3
Ontology : AmiGOmitotic sister chromatid segregation  condensin complex  condensin complex  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  cytosol  mitotic chromosome condensation  meiotic chromosome condensation  nuclear speck  meiotic chromosome segregation  protein heterodimerization activity  cell division  kinetochore organization  
Ontology : EGO-EBImitotic sister chromatid segregation  condensin complex  condensin complex  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  cytosol  mitotic chromosome condensation  meiotic chromosome condensation  nuclear speck  meiotic chromosome segregation  protein heterodimerization activity  cell division  kinetochore organization  
NDEx NetworkSMC4
Atlas of Cancer Signalling NetworkSMC4
Wikipedia pathwaysSMC4
Orthology - Evolution
OrthoDB10051
GeneTree (enSembl)ENSG00000113810
Phylogenetic Trees/Animal Genes : TreeFamSMC4
HOVERGENQ9NTJ3
HOGENOMQ9NTJ3
Homologs : HomoloGeneSMC4
Homology/Alignments : Family Browser (UCSC)SMC4
Gene fusions - Rearrangements
Tumor Fusion PortalSMC4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSMC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SMC4
dbVarSMC4
ClinVarSMC4
1000_GenomesSMC4 
Exome Variant ServerSMC4
ExAC (Exome Aggregation Consortium)ENSG00000113810
GNOMAD BrowserENSG00000113810
Genetic variants : HAPMAP10051
Genomic Variants (DGV)SMC4 [DGVbeta]
DECIPHERSMC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSMC4 
Mutations
ICGC Data PortalSMC4 
TCGA Data PortalSMC4 
Broad Tumor PortalSMC4
OASIS PortalSMC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSMC4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSMC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SMC4
DgiDB (Drug Gene Interaction Database)SMC4
DoCM (Curated mutations)SMC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SMC4 (select a term)
intoGenSMC4
Cancer3DSMC4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605575   
Orphanet
DisGeNETSMC4
MedgenSMC4
Genetic Testing Registry SMC4
NextProtQ9NTJ3 [Medical]
TSGene10051
GENETestsSMC4
Target ValidationSMC4
Huge Navigator SMC4 [HugePedia]
snp3D : Map Gene to Disease10051
BioCentury BCIQSMC4
ClinGenSMC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10051
Chemical/Pharm GKB GenePA37834
Clinical trialSMC4
Miscellaneous
canSAR (ICR)SMC4 (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSMC4
EVEXSMC4
GoPubMedSMC4
iHOPSMC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 21 14:35:36 CET 2017

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