Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SMC6 (structural maintenance of chromosomes 6)

Identity

Alias_namesSMC6L1
SMC6 structural maintenance of chromosomes 6-like 1 (yeast)
Alias_symbol (synonym)FLJ22116
Other aliasSMC-6
hSMC6
HGNC (Hugo) SMC6
LocusID (NCBI) 79677
Atlas_Id 45657
Location 2p24.2  [Link to chromosome band 2p24]
Location_base_pair Starts at 17845079 and ends at 17935096 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SMC6 (2p24.2) / FAM114A2 (5q33.2)SMC6 (2p24.2) / PTPRA (20p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SMC6   20466
Cards
Entrez_Gene (NCBI)SMC6  79677  structural maintenance of chromosomes 6
AliasesSMC-6; SMC6L1; hSMC6
GeneCards (Weizmann)SMC6
Ensembl hg19 (Hinxton)ENSG00000163029 [Gene_View]  chr2:17845079-17935096 [Contig_View]  SMC6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000163029 [Gene_View]  chr2:17845079-17935096 [Contig_View]  SMC6 [Vega]
ICGC DataPortalENSG00000163029
TCGA cBioPortalSMC6
AceView (NCBI)SMC6
Genatlas (Paris)SMC6
WikiGenes79677
SOURCE (Princeton)SMC6
Genetics Home Reference (NIH)SMC6
Genomic and cartography
GoldenPath hg19 (UCSC)SMC6  -     chr2:17845079-17935096 -  2p24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SMC6  -     2p24.2   [Description]    (hg38-Dec_2013)
EnsemblSMC6 - 2p24.2 [CytoView hg19]  SMC6 - 2p24.2 [CytoView hg38]
Mapping of homologs : NCBISMC6 [Mapview hg19]  SMC6 [Mapview hg38]
OMIM609387   
Gene and transcription
Genbank (Entrez)AJ310551 AK025769 AK092853 AK098325 AK124545
RefSeq transcript (Entrez)NM_001142286 NM_024624
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929299
Consensus coding sequences : CCDS (NCBI)SMC6
Cluster EST : UnigeneHs.526728 [ NCBI ]
CGAP (NCI)Hs.526728
Alternative Splicing GalleryENSG00000163029
Gene ExpressionSMC6 [ NCBI-GEO ]   SMC6 [ EBI - ARRAY_EXPRESS ]   SMC6 [ SEEK ]   SMC6 [ MEM ]
Gene Expression Viewer (FireBrowse)SMC6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79677
GTEX Portal (Tissue expression)SMC6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96SB8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96SB8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96SB8
Splice isoforms : SwissVarQ96SB8
PhosPhoSitePlusQ96SB8
Domains : Interpro (EBI)P-loop_NTPase    RecF/RecN/SMC_N    SMC6   
Domain families : Pfam (Sanger)SMC_N (PF02463)   
Domain families : Pfam (NCBI)pfam02463   
Conserved Domain (NCBI)SMC6
DMDM Disease mutations79677
Blocks (Seattle)SMC6
SuperfamilyQ96SB8
Human Protein AtlasENSG00000163029
Peptide AtlasQ96SB8
HPRD10242
IPIIPI00154528   IPI00816217   IPI00894312   IPI00892988   
Protein Interaction databases
DIP (DOE-UCLA)Q96SB8
IntAct (EBI)Q96SB8
FunCoupENSG00000163029
BioGRIDSMC6
STRING (EMBL)SMC6
ZODIACSMC6
Ontologies - Pathways
QuickGOQ96SB8
Ontology : AmiGOtelomere maintenance via recombination  double-strand break repair via homologous recombination  chromosome, telomeric region  sex chromosome  protein binding  ATP binding  intracellular  nucleus  nucleoplasm  nucleoplasm  cellular response to DNA damage stimulus  PML body  nuclear speck  protein sumoylation  Smc5-Smc6 complex  ubiquitin protein ligase binding  interchromatin granule  site of double-strand break  positive regulation of chromosome segregation  cellular senescence  
Ontology : EGO-EBItelomere maintenance via recombination  double-strand break repair via homologous recombination  chromosome, telomeric region  sex chromosome  protein binding  ATP binding  intracellular  nucleus  nucleoplasm  nucleoplasm  cellular response to DNA damage stimulus  PML body  nuclear speck  protein sumoylation  Smc5-Smc6 complex  ubiquitin protein ligase binding  interchromatin granule  site of double-strand break  positive regulation of chromosome segregation  cellular senescence  
NDEx NetworkSMC6
Atlas of Cancer Signalling NetworkSMC6
Wikipedia pathwaysSMC6
Orthology - Evolution
OrthoDB79677
GeneTree (enSembl)ENSG00000163029
Phylogenetic Trees/Animal Genes : TreeFamSMC6
HOVERGENQ96SB8
HOGENOMQ96SB8
Homologs : HomoloGeneSMC6
Homology/Alignments : Family Browser (UCSC)SMC6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSMC6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SMC6
dbVarSMC6
ClinVarSMC6
1000_GenomesSMC6 
Exome Variant ServerSMC6
ExAC (Exome Aggregation Consortium)SMC6 (select the gene name)
Genetic variants : HAPMAP79677
Genomic Variants (DGV)SMC6 [DGVbeta]
DECIPHER (Syndromes)2:17845079-17935096  ENSG00000163029
CONAN: Copy Number AnalysisSMC6 
Mutations
ICGC Data PortalSMC6 
TCGA Data PortalSMC6 
Broad Tumor PortalSMC6
OASIS PortalSMC6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSMC6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSMC6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SMC6
DgiDB (Drug Gene Interaction Database)SMC6
DoCM (Curated mutations)SMC6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SMC6 (select a term)
intoGenSMC6
Cancer3DSMC6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609387   
Orphanet
MedgenSMC6
Genetic Testing Registry SMC6
NextProtQ96SB8 [Medical]
TSGene79677
GENETestsSMC6
Huge Navigator SMC6 [HugePedia]
snp3D : Map Gene to Disease79677
BioCentury BCIQSMC6
ClinGenSMC6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79677
Chemical/Pharm GKB GenePA134892702
Clinical trialSMC6
Miscellaneous
canSAR (ICR)SMC6 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSMC6
EVEXSMC6
GoPubMedSMC6
iHOPSMC6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:28:17 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.