SMG7 (SMG7 nonsense mediated mRNA decay factor)

2019-04-01  

Identity

HGNC
LOCATION
1q25.3
LOCUSID
ALIAS
C1orf16,EST1C,SGA56M
FUSION GENES

Other Information

Locus ID:

NCBI: 9887
MIM: 610964
HGNC: 16792
Ensembl: ENSG00000116698

Variants:

dbSNP: 9887
ClinVar: 9887
TCGA: ENSG00000116698
COSMIC: SMG7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116698ENST00000347615Q92540
ENSG00000116698ENST00000367537E9PD50
ENSG00000116698ENST00000419169B1ALB4
ENSG00000116698ENST00000440812E9PEK3
ENSG00000116698ENST00000444547E9PBK2
ENSG00000116698ENST00000502375D6R9J3
ENSG00000116698ENST00000507469Q92540
ENSG00000116698ENST00000507691D6RAD0
ENSG00000116698ENST00000508461Q92540
ENSG00000116698ENST00000515829Q92540
ENSG00000116698ENST00000638826E9PBK2

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
146365772003Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.131
252110802014The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication.65
250131722014Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6.39
278644722017Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways.30
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
284616252017Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates.9
267831092016Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production.2
277718862017Frameshift Mutations of SMG7 Essential for Nonsense-Mediated mRNA Decay in Gastric and Colorectal Cancers.0

Citation

Dessen P

SMG7 (SMG7 nonsense mediated mRNA decay factor)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57857/smg7