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SMG8 (SMG8 nonsense mediated mRNA decay factor)

Identity

Alias_namesC17orf71
chromosome 17 open reading frame 71
smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
Alias_symbol (synonym)FLJ10587
FLJ23205
Other alias
HGNC (Hugo) SMG8
LocusID (NCBI) 55181
Atlas_Id 73558
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at 57287371 and ends at 57292611 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FERMT2 (14q22.1) / SMG8 (17q22)GDPD1 (17q22) / SMG8 (17q22)PRR11 (17q22) / SMG8 (17q22)
SMG8 (17q22) / SMG8 (17q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SMG8   25551
Cards
Entrez_Gene (NCBI)SMG8  55181  SMG8 nonsense mediated mRNA decay factor
AliasesC17orf71
GeneCards (Weizmann)SMG8
Ensembl hg19 (Hinxton)ENSG00000167447 [Gene_View]  chr17:57287371-57292611 [Contig_View]  SMG8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000167447 [Gene_View]  chr17:57287371-57292611 [Contig_View]  SMG8 [Vega]
ICGC DataPortalENSG00000167447
TCGA cBioPortalSMG8
AceView (NCBI)SMG8
Genatlas (Paris)SMG8
WikiGenes55181
SOURCE (Princeton)SMG8
Genetics Home Reference (NIH)SMG8
Genomic and cartography
GoldenPath hg19 (UCSC)SMG8  -     chr17:57287371-57292611 +  17q22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SMG8  -     17q22   [Description]    (hg38-Dec_2013)
EnsemblSMG8 - 17q22 [CytoView hg19]  SMG8 - 17q22 [CytoView hg38]
Mapping of homologs : NCBISMG8 [Mapview hg19]  SMG8 [Mapview hg38]
OMIM613175   
Gene and transcription
Genbank (Entrez)AF349467 AK001449 AK026858 AL834490 BC020957
RefSeq transcript (Entrez)NM_018149
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)SMG8
Cluster EST : UnigeneHs.7296 [ NCBI ]
CGAP (NCI)Hs.7296
Alternative Splicing GalleryENSG00000167447
Gene ExpressionSMG8 [ NCBI-GEO ]   SMG8 [ EBI - ARRAY_EXPRESS ]   SMG8 [ SEEK ]   SMG8 [ MEM ]
Gene Expression Viewer (FireBrowse)SMG8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55181
GTEX Portal (Tissue expression)SMG8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8ND04   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8ND04  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8ND04
Splice isoforms : SwissVarQ8ND04
PhosPhoSitePlusQ8ND04
Domains : Interpro (EBI)SMG8    Smg8/Smg9   
Domain families : Pfam (Sanger)DUF2146 (PF10220)   
Domain families : Pfam (NCBI)pfam10220   
Conserved Domain (NCBI)SMG8
DMDM Disease mutations55181
Blocks (Seattle)SMG8
SuperfamilyQ8ND04
Human Protein AtlasENSG00000167447
Peptide AtlasQ8ND04
HPRD08551
IPIIPI00328183   IPI00867503   IPI00847523   
Protein Interaction databases
DIP (DOE-UCLA)Q8ND04
IntAct (EBI)Q8ND04
FunCoupENSG00000167447
BioGRIDSMG8
STRING (EMBL)SMG8
ZODIACSMG8
Ontologies - Pathways
QuickGOQ8ND04
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, nonsense-mediated decay  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  protein binding  cellular_component  cytosol  gene expression  regulation of protein kinase activity  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, nonsense-mediated decay  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  protein binding  cellular_component  cytosol  gene expression  regulation of protein kinase activity  
NDEx NetworkSMG8
Atlas of Cancer Signalling NetworkSMG8
Wikipedia pathwaysSMG8
Orthology - Evolution
OrthoDB55181
GeneTree (enSembl)ENSG00000167447
Phylogenetic Trees/Animal Genes : TreeFamSMG8
HOVERGENQ8ND04
HOGENOMQ8ND04
Homologs : HomoloGeneSMG8
Homology/Alignments : Family Browser (UCSC)SMG8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSMG8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SMG8
dbVarSMG8
ClinVarSMG8
1000_GenomesSMG8 
Exome Variant ServerSMG8
ExAC (Exome Aggregation Consortium)SMG8 (select the gene name)
Genetic variants : HAPMAP55181
Genomic Variants (DGV)SMG8 [DGVbeta]
DECIPHER (Syndromes)17:57287371-57292611  ENSG00000167447
CONAN: Copy Number AnalysisSMG8 
Mutations
ICGC Data PortalSMG8 
TCGA Data PortalSMG8 
Broad Tumor PortalSMG8
OASIS PortalSMG8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSMG8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSMG8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SMG8
DgiDB (Drug Gene Interaction Database)SMG8
DoCM (Curated mutations)SMG8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SMG8 (select a term)
intoGenSMG8
Cancer3DSMG8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613175   
Orphanet
MedgenSMG8
Genetic Testing Registry SMG8
NextProtQ8ND04 [Medical]
TSGene55181
GENETestsSMG8
Huge Navigator SMG8 [HugePedia]
snp3D : Map Gene to Disease55181
BioCentury BCIQSMG8
ClinGenSMG8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55181
Chemical/Pharm GKB GenePA142672219
Clinical trialSMG8
Miscellaneous
canSAR (ICR)SMG8 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSMG8
EVEXSMG8
GoPubMedSMG8
iHOPSMG8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:44:10 CET 2017

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