Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SMOC2 (SPARC related modular calcium binding 2)

Identity

Other aliasDTDP1
MST117
MSTP117
MSTP140
SMAP2
bA270C4A.1
bA37D8.1
dJ421D16.1
HGNC (Hugo) SMOC2
LocusID (NCBI) 64094
Atlas_Id 56922
Location 6q27  [Link to chromosome band 6q27]
Location_base_pair Starts at 168441151 and ends at 168667994 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SMOC2 (6q27) / SCRN3 (2q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SMOC2   20323
Cards
Entrez_Gene (NCBI)SMOC2  64094  SPARC related modular calcium binding 2
AliasesDTDP1; MST117; MSTP117; MSTP140; 
SMAP2; bA270C4A.1; bA37D8.1; dJ421D16.1
GeneCards (Weizmann)SMOC2
Ensembl hg19 (Hinxton)ENSG00000112562 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112562 [Gene_View]  ENSG00000112562 [Sequence]  chr6:168441151-168667994 [Contig_View]  SMOC2 [Vega]
ICGC DataPortalENSG00000112562
TCGA cBioPortalSMOC2
AceView (NCBI)SMOC2
Genatlas (Paris)SMOC2
WikiGenes64094
SOURCE (Princeton)SMOC2
Genetics Home Reference (NIH)SMOC2
Genomic and cartography
GoldenPath hg38 (UCSC)SMOC2  -     chr6:168441151-168667994 +  6q27   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SMOC2  -     6q27   [Description]    (hg19-Feb_2009)
EnsemblSMOC2 - 6q27 [CytoView hg19]  SMOC2 - 6q27 [CytoView hg38]
Mapping of homologs : NCBISMOC2 [Mapview hg19]  SMOC2 [Mapview hg38]
OMIM125400   607223   
Gene and transcription
Genbank (Entrez)AB014730 AB014737 AF173892 AF176778 AI032288
RefSeq transcript (Entrez)NM_001166412 NM_022138
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SMOC2
Cluster EST : UnigeneHs.487200 [ NCBI ]
CGAP (NCI)Hs.487200
Alternative Splicing GalleryENSG00000112562
Gene ExpressionSMOC2 [ NCBI-GEO ]   SMOC2 [ EBI - ARRAY_EXPRESS ]   SMOC2 [ SEEK ]   SMOC2 [ MEM ]
Gene Expression Viewer (FireBrowse)SMOC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64094
GTEX Portal (Tissue expression)SMOC2
Human Protein AtlasENSG00000112562-SMOC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H3U7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H3U7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H3U7
Splice isoforms : SwissVarQ9H3U7
PhosPhoSitePlusQ9H3U7
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    KAZAL_2 (PS51465)    THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    Kazal_dom    Kazal_dom_sf    SMOC2_EC    SPARC/Testican_Ca-bd-dom    Thyroglobulin_1    Thyroglobulin_1_sf   
Domain families : Pfam (Sanger)Kazal_2 (PF07648)    SPARC_Ca_bdg (PF10591)    Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam07648    pfam10591    pfam00086   
Domain families : Smart (EMBL)KAZAL (SM00280)  TY (SM00211)  
Conserved Domain (NCBI)SMOC2
DMDM Disease mutations64094
Blocks (Seattle)SMOC2
SuperfamilyQ9H3U7
Human Protein Atlas [tissue]ENSG00000112562-SMOC2 [tissue]
Peptide AtlasQ9H3U7
IPIIPI00301528   IPI00644807   IPI00984971   IPI00872631   IPI00385084   IPI00871772   
Protein Interaction databases
DIP (DOE-UCLA)Q9H3U7
IntAct (EBI)Q9H3U7
FunCoupENSG00000112562
BioGRIDSMOC2
STRING (EMBL)SMOC2
ZODIACSMOC2
Ontologies - Pathways
QuickGOQ9H3U7
Ontology : AmiGOcalcium ion binding  basement membrane  interstitial matrix  extracellular space  heparin binding  positive regulation of endothelial cell migration  positive regulation of cell-substrate adhesion  extracellular matrix organization  positive regulation of vascular wound healing  positive regulation of angiogenesis  positive regulation of angiogenesis  positive regulation of mitotic cell cycle  cell periphery  positive regulation of vascular endothelial growth factor signaling pathway  positive regulation of DNA biosynthetic process  positive regulation of DNA biosynthetic process  positive regulation of endothelial cell chemotaxis  
Ontology : EGO-EBIcalcium ion binding  basement membrane  interstitial matrix  extracellular space  heparin binding  positive regulation of endothelial cell migration  positive regulation of cell-substrate adhesion  extracellular matrix organization  positive regulation of vascular wound healing  positive regulation of angiogenesis  positive regulation of angiogenesis  positive regulation of mitotic cell cycle  cell periphery  positive regulation of vascular endothelial growth factor signaling pathway  positive regulation of DNA biosynthetic process  positive regulation of DNA biosynthetic process  positive regulation of endothelial cell chemotaxis  
NDEx NetworkSMOC2
Atlas of Cancer Signalling NetworkSMOC2
Wikipedia pathwaysSMOC2
Orthology - Evolution
OrthoDB64094
GeneTree (enSembl)ENSG00000112562
Phylogenetic Trees/Animal Genes : TreeFamSMOC2
HOVERGENQ9H3U7
HOGENOMQ9H3U7
Homologs : HomoloGeneSMOC2
Homology/Alignments : Family Browser (UCSC)SMOC2
Gene fusions - Rearrangements
Fusion : QuiverSMOC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSMOC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SMOC2
dbVarSMOC2
ClinVarSMOC2
1000_GenomesSMOC2 
Exome Variant ServerSMOC2
ExAC (Exome Aggregation Consortium)ENSG00000112562
GNOMAD BrowserENSG00000112562
Varsome BrowserSMOC2
Genetic variants : HAPMAP64094
Genomic Variants (DGV)SMOC2 [DGVbeta]
DECIPHERSMOC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSMOC2 
Mutations
ICGC Data PortalSMOC2 
TCGA Data PortalSMOC2 
Broad Tumor PortalSMOC2
OASIS PortalSMOC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSMOC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSMOC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SMOC2
DgiDB (Drug Gene Interaction Database)SMOC2
DoCM (Curated mutations)SMOC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SMOC2 (select a term)
intoGenSMOC2
Cancer3DSMOC2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM125400    607223   
Orphanet
DisGeNETSMOC2
MedgenSMOC2
Genetic Testing Registry SMOC2
NextProtQ9H3U7 [Medical]
TSGene64094
GENETestsSMOC2
Target ValidationSMOC2
Huge Navigator SMOC2 [HugePedia]
snp3D : Map Gene to Disease64094
BioCentury BCIQSMOC2
ClinGenSMOC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64094
Chemical/Pharm GKB GenePA134934590
Clinical trialSMOC2
Miscellaneous
canSAR (ICR)SMOC2 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSMOC2
EVEXSMOC2
GoPubMedSMOC2
iHOPSMOC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:40:38 CET 2018

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