SMOX (spermine oxidase)

2007-02-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
C20orf16,PAO,PAO-1,PAO1,PAOH,PAOH1,SMO
FUSION GENES

Other Information

Locus ID:

NCBI: 54498
MIM: 615854
HGNC: 15862
Ensembl: ENSG00000088826

Variants:

dbSNP: 54498
ClinVar: 54498
TCGA: ENSG00000088826
COSMIC: SMOX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088826ENST00000278795Q9NWM0
ENSG00000088826ENST00000305958Q9NWM0
ENSG00000088826ENST00000339123Q9NWM0
ENSG00000088826ENST00000346595Q9NWM0
ENSG00000088826ENST00000379460Q9NWM0
ENSG00000088826ENST00000457205Q5TE25
ENSG00000088826ENST00000621355Q9NWM0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
beta-Alanine metabolismKEGGko00410
Arginine and proline metabolismKEGGhsa00330
beta-Alanine metabolismKEGGhsa00410
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Interconversion of polyaminesREACTOMER-HSA-351200
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Amine Oxidase reactionsREACTOMER-HSA-140179
PAOs oxidise polyamines to aminesREACTOMER-HSA-141334

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
218390412011Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA.54
127271962003Properties of purified recombinant human polyamine oxidase, PAOh1/SMO.52
162077102005Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.43
184226502008Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology.32
183022212008Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues.31
251743982015Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.30
240251542014Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers.25
236654282013A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity.21
197277322010The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines.19

Citation

Dessen P

SMOX (spermine oxidase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46474/smox