Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6610
MIM: 603498
HGNC: 11121
Ensembl: ENSG00000135587
Variants:
dbSNP: 6610
ClinVar: 6610
TCGA: ENSG00000135587
COSMIC: SMPD2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000135587 | ENST00000258052 | O60906 |
| ENSG00000135587 | ENST00000458487 | H0Y5N2 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37904133 | 2023 | Neutral sphingomyelinase inhibition promotes local and network degeneration in vitro and in vivo. | 1 |
| 37904133 | 2023 | Neutral sphingomyelinase inhibition promotes local and network degeneration in vitro and in vivo. | 1 |
| 32661777 | 2020 | Genome-wide methylation association with current suicidal ideation in schizophrenia. | 3 |
| 32661777 | 2020 | Genome-wide methylation association with current suicidal ideation in schizophrenia. | 3 |
| 30106227 | 2018 | Exosomal neutral sphingomyelinase 1 suppresses hepatocellular carcinoma via decreasing the ratio of sphingomyelin/ceramide. | 26 |
| 30106227 | 2018 | Exosomal neutral sphingomyelinase 1 suppresses hepatocellular carcinoma via decreasing the ratio of sphingomyelin/ceramide. | 26 |
| 25168245 | 2015 | Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. | 51 |
| 25224994 | 2015 | Neutral sphingomyelinase 2 is a key factor for PorB-dependent invasion of Neisseria gonorrhoeae. | 12 |
| 25168245 | 2015 | Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. | 51 |
| 25224994 | 2015 | Neutral sphingomyelinase 2 is a key factor for PorB-dependent invasion of Neisseria gonorrhoeae. | 12 |
| 24358176 | 2013 | Ceramide mediates Ox-LDL-induced human vascular smooth muscle cell calcification via p38 mitogen-activated protein kinase signaling. | 33 |
| 24358176 | 2013 | Ceramide mediates Ox-LDL-induced human vascular smooth muscle cell calcification via p38 mitogen-activated protein kinase signaling. | 33 |
| 22899568 | 2012 | Hyperosmolarity-induced lipid droplet formation depends on ceramide production by neutral sphingomyelinase 2. | 11 |
| 22899568 | 2012 | Hyperosmolarity-induced lipid droplet formation depends on ceramide production by neutral sphingomyelinase 2. | 11 |
| 20378749 | 2011 | An obligate role for membrane-associated neutral sphingomyelinase activity in orienting chemotactic migration of human neutrophils. | 17 |
Citation
Dessen P
SMPD2 (sphingomyelin phosphodiesterase 2)
Atlas Genet Cytogenet Oncol Haematol. 2011-02-01
Online version: http://atlasgeneticsoncology.org/gene/52064/smpd2
