Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SMURF1 (SMAD specific E3 ubiquitin protein ligase 1)

Identity

Other names-
HGNC (Hugo) SMURF1
LocusID (NCBI) 57154
Location 7q22.1
Location_base_pair Starts at 98625058 and ends at 98741743 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SMURF1   16807
Entrez_Gene (NCBI)SMURF1  57154  SMAD specific E3 ubiquitin protein ligase 1
Cards
GeneCards (Weizmann)SMURF1
Ensembl (Hinxton)ENSG00000198742 [Gene_View]  chr7:98625058-98741743 [Contig_View]  SMURF1 [Vega]
AceView (NCBI)SMURF1
Genatlas (Paris)SMURF1
SOURCE (Stanford)NM_001199847 NM_020429 NM_181349
Genomic and cartography
GoldenPath (UCSC)SMURF1  -  7q22.1   chr7:98625058-98741743 -  7q22.1   [Description]    (hg19-Feb_2009)
EnsemblSMURF1 - 7q22.1 [CytoView]
Mapping of homologs : NCBISMURF1 [Mapview]
OMIM605568   
Gene and transcription
Genbank (Entrez)AB046845 AF199364 AF464850 AK057024 AK126471
RefSeq transcript (SRS)NM_001199847 NM_020429 NM_181349
RefSeq transcript (Entrez)NM_001199847 NM_020429 NM_181349
RefSeq genomic (SRS)AC_000068 AC_000139 NC_000007 NC_018918 NT_007933 NT_079595 NW_001839064 NW_004078032
RefSeq genomic (Entrez)AC_000068 AC_000139 NC_000007 NC_018918 NT_007933 NT_079595 NW_001839064 NW_004078032
Consensus coding sequences : CCDS (NCBI)SMURF1
Cluster EST : UnigeneHs.189329 [ SRS ] Hs.189329 [ NCBI ]
CGAP (NCI)Hs.189329
Alternative Splicing : Fast-db (Paris)GSHG0028384
Alternative Splicing GalleryENSG00000198742
Gene ExpressionSMURF1 [ NCBI-GEO ]   SMURF1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCE7 (SRS) Q9HCE7 (Uniprot)
NextProtQ9HCE7
With graphics : InterProQ9HCE7
Splice isoforms : SwissVarQ9HCE7(Swissvar)
Domaine pattern : Prosite (SRS)C2 (PS50004)    HECT (PS50237)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    HECT (PS50237)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (SRS)C2_Ca-dep    C2_Ca/lipid-bd_dom_CaLB    C2_membr_targeting    E3_ub_ligase_SMURF1    HECT    WW_Rsp5_WWP   
Domains : Interpro (EBI)C2_Ca-dep    C2_Ca/lipid-bd_dom_CaLB    C2_membr_targeting    E3_ub_ligase_SMURF1    HECT    WW_Rsp5_WWP   
Related proteins : CluSTrQ9HCE7
Domain families : Pfam (SRS)C2 (PF00168)    HECT (PF00632)    WW (PF00397)   
Domain families : Pfam (Sanger)C2 (PF00168)    HECT (PF00632)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00168    pfam00632    pfam00397   
Domain families : Smart (EMBL)C2 (SM00239)  HECTc (SM00119)  WW (SM00456)  
DMDM57154
Blocks (Seattle)Q9HCE7
PDB (SRS)2LAZ    2LB0    2LB1    3PYC   
PDB (PDBSum)2LAZ    2LB0    2LB1    3PYC   
PDB (IMB)2LAZ    2LB0    2LB1    3PYC   
PDB (RSDB)2LAZ    2LB0    2LB1    3PYC   
Human Protein AtlasENSG00000198742
HPRD06902
IPIIPI00217054   IPI00219332   IPI00979334   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCE7
IntAct (EBI)Q9HCE7
FunCoupENSG00000198742
REACTOMESMURF1
Protein Interaction Database57154
BioGRIDSMURF1
InParanoidQ9HCE7
Interologous Interaction database Q9HCE7
IntegromeDBSMURF1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SMURF1
SNP (GeneSNP Utah)SMURF1
SNP : HGBaseSMURF1
Genetic variants : HAPMAPSMURF1
Somatic Mutations in Cancer : COSMICSMURF1 
CONAN: Copy Number AnalysisSMURF1 
Mutations and Diseases : HGMDSMURF1
OMIM605568   
GENETests605568   
Disease Genetic AssociationSMURF1
Huge Navigator SMURF1 [HugePedia]  SMURF1 [HugeCancerGEM]
Genomic VariantsSMURF1  SMURF1 [DGVbeta]
snp3D : Map Gene to Disease57154
General knowledge
Homologs : HomoloGeneSMURF1
Homology/Alignments : Family Browser (UCSC)SMURF1
Phylogenetic Trees/Animal Genes : TreeFamSMURF1
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.- [ Enzyme-SRS ]   6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
Chemical/Protein Interactions : CTD57154
Chemical/Pharm GKB GenePA134987175
Clinical trialSMURF1
Cancer Resource (Charite)ENSG00000198742
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein ligase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  protein export from nucleus  transforming growth factor beta receptor signaling pathway  ectoderm development  protein ubiquitination  cell differentiation  negative regulation of ossification  BMP signaling pathway  BMP signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of BMP signaling pathway  ubiquitin-dependent SMAD protein catabolic process  positive regulation of protein ubiquitination  receptor catabolic process  axon part  protein localization to cell surface  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  neuronal cell body  proteasomal ubiquitin-dependent protein catabolic process  activin binding  I-SMAD binding  R-SMAD binding  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein ligase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  protein export from nucleus  transforming growth factor beta receptor signaling pathway  ectoderm development  protein ubiquitination  cell differentiation  negative regulation of ossification  BMP signaling pathway  BMP signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of BMP signaling pathway  ubiquitin-dependent SMAD protein catabolic process  positive regulation of protein ubiquitination  receptor catabolic process  axon part  protein localization to cell surface  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  neuronal cell body  proteasomal ubiquitin-dependent protein catabolic process  activin binding  I-SMAD binding  R-SMAD binding  
Pathways : BIOCARTAEstrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]   
Pathways : KEGGTGF-beta signaling pathwayUbiquitin mediated proteolysis
Other databases
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
PubGeneSMURF1
iHOPSMURF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:31:50 CEST 2013
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