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SMURF1 (SMAD specific E3 ubiquitin protein ligase 1)

Identity

Other names-
HGNC (Hugo) SMURF1
LocusID (NCBI) 57154
Atlas_Id 45826
Location 7q22.1
Location_base_pair Starts at 98625058 and ends at 98741743 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SMURF1   16807
Cards
Entrez_Gene (NCBI)SMURF1  57154  SMAD specific E3 ubiquitin protein ligase 1
GeneCards (Weizmann)SMURF1
Ensembl hg19 (Hinxton)ENSG00000198742 [Gene_View]  chr7:98625058-98741743 [Contig_View]  SMURF1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000198742 [Gene_View]  chr7:98625058-98741743 [Contig_View]  SMURF1 [Vega]
ICGC DataPortalENSG00000198742
TCGA cBioPortalSMURF1
AceView (NCBI)SMURF1
Genatlas (Paris)SMURF1
WikiGenes57154
SOURCE (Princeton)SMURF1
Genomic and cartography
GoldenPath hg19 (UCSC)SMURF1  -     chr7:98625058-98741743 -  7q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SMURF1  -     7q22.1   [Description]    (hg38-Dec_2013)
EnsemblSMURF1 - 7q22.1 [CytoView hg19]  SMURF1 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBISMURF1 [Mapview hg19]  SMURF1 [Mapview hg38]
OMIM605568   
Gene and transcription
Genbank (Entrez)AB046845 AF199364 AF464850 AK057024 AK126471
RefSeq transcript (Entrez)NM_001199847 NM_020429 NM_181349
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)SMURF1
Cluster EST : UnigeneHs.189329 [ NCBI ]
CGAP (NCI)Hs.189329
Alternative Splicing : Fast-db (Paris)GSHG0028384
Alternative Splicing GalleryENSG00000198742
Gene ExpressionSMURF1 [ NCBI-GEO ]     SMURF1 [ SEEK ]   SMURF1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCE7 (Uniprot)
NextProtQ9HCE7  [Medical]
With graphics : InterProQ9HCE7
Splice isoforms : SwissVarQ9HCE7 (Swissvar)
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    HECT (PS50237)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)C2_dom    E3_ub_ligase_SMURF1    HECT    WW_dom   
Related proteins : CluSTrQ9HCE7
Domain families : Pfam (Sanger)C2 (PF00168)    HECT (PF00632)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00168    pfam00632    pfam00397   
Domain families : Smart (EMBL)C2 (SM00239)  HECTc (SM00119)  WW (SM00456)  
DMDM Disease mutations57154
Blocks (Seattle)Q9HCE7
PDB (SRS)2LAZ    2LB0    2LB1    2LTX    3PYC   
PDB (PDBSum)2LAZ    2LB0    2LB1    2LTX    3PYC   
PDB (IMB)2LAZ    2LB0    2LB1    2LTX    3PYC   
PDB (RSDB)2LAZ    2LB0    2LB1    2LTX    3PYC   
Human Protein AtlasENSG00000198742
Peptide AtlasQ9HCE7
HPRD06902
IPIIPI00217054   IPI00219332   IPI00979334   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCE7
IntAct (EBI)Q9HCE7
FunCoupENSG00000198742
BioGRIDSMURF1
IntegromeDBSMURF1
STRING (EMBL)SMURF1
Ontologies - Pathways
QuickGOQ9HCE7
Ontology : AmiGOprotein polyubiquitination  positive regulation of defense response to virus by host  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  plasma membrane  protein export from nucleus  transforming growth factor beta receptor signaling pathway  ectoderm development  protein ubiquitination  ligase activity  cell differentiation  negative regulation of ossification  axon  BMP signaling pathway  BMP signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of BMP signaling pathway  ubiquitin-dependent SMAD protein catabolic process  receptor catabolic process  protein localization to cell surface  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  neuronal cell body  proteasome-mediated ubiquitin-dependent protein catabolic process  activin binding  ubiquitin protein ligase activity  extracellular exosome  I-SMAD binding  R-SMAD binding  regulation of autophagic vacuole fusion  regulation of mitochondrion degradation  positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
Ontology : EGO-EBIprotein polyubiquitination  positive regulation of defense response to virus by host  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  plasma membrane  protein export from nucleus  transforming growth factor beta receptor signaling pathway  ectoderm development  protein ubiquitination  ligase activity  cell differentiation  negative regulation of ossification  axon  BMP signaling pathway  BMP signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of BMP signaling pathway  ubiquitin-dependent SMAD protein catabolic process  receptor catabolic process  protein localization to cell surface  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  neuronal cell body  proteasome-mediated ubiquitin-dependent protein catabolic process  activin binding  ubiquitin protein ligase activity  extracellular exosome  I-SMAD binding  R-SMAD binding  regulation of autophagic vacuole fusion  regulation of mitochondrion degradation  positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
Pathways : BIOCARTAEstrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]   
Pathways : KEGGUbiquitin mediated proteolysis    Endocytosis    TGF-beta signaling pathway   
Protein Interaction DatabaseSMURF1
DoCM (Curated mutations)SMURF1
Wikipedia pathwaysSMURF1
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerSMURF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SMURF1
dbVarSMURF1
ClinVarSMURF1
1000_GenomesSMURF1 
Exome Variant ServerSMURF1
SNP (GeneSNP Utah)SMURF1
SNP : HGBaseSMURF1
Genetic variants : HAPMAPSMURF1
Genomic Variants (DGV)SMURF1 [DGVbeta]
Mutations
ICGC Data PortalSMURF1 
TCGA Data PortalSMURF1 
Tumor PortalSMURF1
Somatic Mutations in Cancer : COSMICSMURF1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:98625058-98741743
CONAN: Copy Number AnalysisSMURF1 
Mutations and Diseases : HGMDSMURF1
OMIM605568   
MedgenSMURF1
NextProtQ9HCE7 [Medical]
GENETestsSMURF1
Disease Genetic AssociationSMURF1
Huge Navigator SMURF1 [HugePedia]  SMURF1 [HugeCancerGEM]
snp3D : Map Gene to Disease57154
DGIdb (Drug Gene Interaction db)SMURF1
General knowledge
Homologs : HomoloGeneSMURF1
Homology/Alignments : Family Browser (UCSC)SMURF1
Phylogenetic Trees/Animal Genes : TreeFamSMURF1
Chemical/Protein Interactions : CTD57154
Chemical/Pharm GKB GenePA134987175
Clinical trialSMURF1
Cancer Resource (Charite)ENSG00000198742
Other databases
Probes
Litterature
PubMed110 Pubmed reference(s) in Entrez
CoreMineSMURF1
GoPubMedSMURF1
iHOPSMURF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 15:16:13 CEST 2015

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