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SMURF1 (SMAD specific E3 ubiquitin protein ligase 1)

Identity

Other names-
HGNC (Hugo) SMURF1
LocusID (NCBI) 57154
Location 7q22.1
Location_base_pair Starts at 98625058 and ends at 98741743 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SMURF1   16807
Cards
Entrez_Gene (NCBI)SMURF1  57154  SMAD specific E3 ubiquitin protein ligase 1
GeneCards (Weizmann)SMURF1
Ensembl (Hinxton)ENSG00000198742 [Gene_View]  chr7:98625058-98741743 [Contig_View]  SMURF1 [Vega]
ICGC DataPortalENSG00000198742
AceView (NCBI)SMURF1
Genatlas (Paris)SMURF1
WikiGenes57154
SOURCE (Princeton)NM_001199847 NM_020429 NM_181349
Genomic and cartography
GoldenPath (UCSC)SMURF1  -  7q22.1   chr7:98625058-98741743 -  7q22.1   [Description]    (hg19-Feb_2009)
EnsemblSMURF1 - 7q22.1 [CytoView]
Mapping of homologs : NCBISMURF1 [Mapview]
OMIM605568   
Gene and transcription
Genbank (Entrez)AB046845 AF199364 AF464850 AK057024 AK126471
RefSeq transcript (Entrez)NM_001199847 NM_020429 NM_181349
RefSeq genomic (Entrez)AC_000139 NC_000007 NC_018918 NT_007933 NW_001839064 NW_004929332
Consensus coding sequences : CCDS (NCBI)SMURF1
Cluster EST : UnigeneHs.189329 [ NCBI ]
CGAP (NCI)Hs.189329
Alternative Splicing : Fast-db (Paris)GSHG0028384
Alternative Splicing GalleryENSG00000198742
Gene ExpressionSMURF1 [ NCBI-GEO ]     SMURF1 [ SEEK ]   SMURF1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCE7 (Uniprot)
NextProtQ9HCE7  [Medical]
With graphics : InterProQ9HCE7
Splice isoforms : SwissVarQ9HCE7 (Swissvar)
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    HECT (PS50237)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)C2_dom    E3_ub_ligase_SMURF1    HECT    WW_dom   
Related proteins : CluSTrQ9HCE7
Domain families : Pfam (Sanger)C2 (PF00168)    HECT (PF00632)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00168    pfam00632    pfam00397   
Domain families : Smart (EMBL)C2 (SM00239)  HECTc (SM00119)  WW (SM00456)  
DMDM Disease mutations57154
Blocks (Seattle)Q9HCE7
PDB (SRS)2LAZ    2LB0    2LB1    2LTX    3PYC   
PDB (PDBSum)2LAZ    2LB0    2LB1    2LTX    3PYC   
PDB (IMB)2LAZ    2LB0    2LB1    2LTX    3PYC   
PDB (RSDB)2LAZ    2LB0    2LB1    2LTX    3PYC   
Human Protein AtlasENSG00000198742
Peptide AtlasQ9HCE7
HPRD06902
IPIIPI00217054   IPI00219332   IPI00979334   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCE7
IntAct (EBI)Q9HCE7
FunCoupENSG00000198742
BioGRIDSMURF1
InParanoidQ9HCE7
Interologous Interaction database Q9HCE7
IntegromeDBSMURF1
STRING (EMBL)SMURF1
Ontologies - Pathways
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  protein export from nucleus  transforming growth factor beta receptor signaling pathway  ectoderm development  protein ubiquitination  ligase activity  cell differentiation  negative regulation of ossification  BMP signaling pathway  BMP signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of BMP signaling pathway  ubiquitin-dependent SMAD protein catabolic process  receptor catabolic process  protein localization to cell surface  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  neuronal cell body  proteasome-mediated ubiquitin-dependent protein catabolic process  activin binding  extracellular vesicular exosome  I-SMAD binding  R-SMAD binding  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  protein export from nucleus  transforming growth factor beta receptor signaling pathway  ectoderm development  protein ubiquitination  ligase activity  cell differentiation  negative regulation of ossification  BMP signaling pathway  BMP signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of BMP signaling pathway  ubiquitin-dependent SMAD protein catabolic process  receptor catabolic process  protein localization to cell surface  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  neuronal cell body  proteasome-mediated ubiquitin-dependent protein catabolic process  activin binding  extracellular vesicular exosome  I-SMAD binding  R-SMAD binding  
Pathways : BIOCARTAEstrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]   
Pathways : KEGGUbiquitin mediated proteolysis    Endocytosis    TGF-beta signaling pathway   
Protein Interaction DatabaseSMURF1
Wikipedia pathwaysSMURF1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SMURF1
SNP (GeneSNP Utah)SMURF1
SNP : HGBaseSMURF1
Genetic variants : HAPMAPSMURF1
1000_GenomesSMURF1 
ICGC programENSG00000198742 
CONAN: Copy Number AnalysisSMURF1 
Somatic Mutations in Cancer : COSMICSMURF1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDSMURF1
OMIM605568   
MedgenSMURF1
GENETestsSMURF1
Disease Genetic AssociationSMURF1
Huge Navigator SMURF1 [HugePedia]  SMURF1 [HugeCancerGEM]
Genomic VariantsSMURF1  SMURF1 [DGVbeta]
Exome VariantSMURF1
dbVarSMURF1
ClinVarSMURF1
snp3D : Map Gene to Disease57154
General knowledge
Homologs : HomoloGeneSMURF1
Homology/Alignments : Family Browser (UCSC)SMURF1
Phylogenetic Trees/Animal Genes : TreeFamSMURF1
Chemical/Protein Interactions : CTD57154
Chemical/Pharm GKB GenePA134987175
Clinical trialSMURF1
Cancer Resource (Charite)ENSG00000198742
Other databases
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
CoreMineSMURF1
iHOPSMURF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 13:17:57 CEST 2014

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