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SMYD1 (SET and MYND domain containing 1)

Identity

Alias (NCBI)BOP
KMT3D
ZMYND18
ZMYND22
HGNC (Hugo) SMYD1
HGNC Alias symbBOP
ZMYND22
KMT3D
LocusID (NCBI) 150572
Atlas_Id 47425
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 88067825 and ends at 88113383 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SMYD1   20986
Cards
Entrez_Gene (NCBI)SMYD1    SET and MYND domain containing 1
AliasesBOP; KMT3D; ZMYND18; ZMYND22
GeneCards (Weizmann)SMYD1
Ensembl hg19 (Hinxton)ENSG00000115593 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115593 [Gene_View]  ENSG00000115593 [Sequence]  chr2:88067825-88113383 [Contig_View]  SMYD1 [Vega]
ICGC DataPortalENSG00000115593
TCGA cBioPortalSMYD1
AceView (NCBI)SMYD1
Genatlas (Paris)SMYD1
SOURCE (Princeton)SMYD1
Genetics Home Reference (NIH)SMYD1
Genomic and cartography
GoldenPath hg38 (UCSC)SMYD1  -     chr2:88067825-88113383 +  2p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SMYD1  -     2p11.2   [Description]    (hg19-Feb_2009)
GoldenPathSMYD1 - 2p11.2 [CytoView hg19]  SMYD1 - 2p11.2 [CytoView hg38]
ImmunoBaseENSG00000115593
Genome Data Viewer NCBISMYD1 [Mapview hg19]  
OMIM606846   
Gene and transcription
Genbank (Entrez)AF086123 AK022290 AK091724 AL832035 AY518933
RefSeq transcript (Entrez)NM_001330364 NM_198274
Consensus coding sequences : CCDS (NCBI)SMYD1
Gene ExpressionSMYD1 [ NCBI-GEO ]   SMYD1 [ EBI - ARRAY_EXPRESS ]   SMYD1 [ SEEK ]   SMYD1 [ MEM ]
Gene Expression Viewer (FireBrowse)SMYD1 [ Firebrowse - Broad ]
GenevisibleExpression of SMYD1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)150572
GTEX Portal (Tissue expression)SMYD1
Human Protein AtlasENSG00000115593-SMYD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NB12   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NB12  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NB12
PhosPhoSitePlusQ8NB12
Domaine pattern : Prosite (Expaxy)SET (PS50280)    ZF_MYND_1 (PS01360)    ZF_MYND_2 (PS50865)   
Domains : Interpro (EBI)SET_dom    TPR-like_helical_dom_sf    Znf_MYND   
Domain families : Pfam (Sanger)SET (PF00856)    zf-MYND (PF01753)   
Domain families : Pfam (NCBI)pfam00856    pfam01753   
Domain families : Smart (EMBL)SET (SM00317)  
Conserved Domain (NCBI)SMYD1
SuperfamilyQ8NB12
AlphaFold pdb e-kbQ8NB12   
Human Protein Atlas [tissue]ENSG00000115593-SMYD1 [tissue]
HPRD06025
Protein Interaction databases
DIP (DOE-UCLA)Q8NB12
IntAct (EBI)Q8NB12
BioGRIDSMYD1
STRING (EMBL)SMYD1
ZODIACSMYD1
Ontologies - Pathways
QuickGOQ8NB12
Ontology : AmiGODNA binding  transcription corepressor activity  protein binding  nucleus  cytoplasm  chromatin remodeling  heart development  positive regulation of myotube differentiation  histone-lysine N-methyltransferase activity  histone lysine methylation  skeletal muscle cell differentiation  positive regulation of myoblast differentiation  negative regulation of transcription, DNA-templated  metal ion binding  
Ontology : EGO-EBIDNA binding  transcription corepressor activity  protein binding  nucleus  cytoplasm  chromatin remodeling  heart development  positive regulation of myotube differentiation  histone-lysine N-methyltransferase activity  histone lysine methylation  skeletal muscle cell differentiation  positive regulation of myoblast differentiation  negative regulation of transcription, DNA-templated  metal ion binding  
NDEx NetworkSMYD1
Atlas of Cancer Signalling NetworkSMYD1
Wikipedia pathwaysSMYD1
Orthology - Evolution
OrthoDB150572
GeneTree (enSembl)ENSG00000115593
Phylogenetic Trees/Animal Genes : TreeFamSMYD1
Homologs : HomoloGeneSMYD1
Homology/Alignments : Family Browser (UCSC)SMYD1
Gene fusions - Rearrangements
Fusion : QuiverSMYD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSMYD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SMYD1
dbVarSMYD1
ClinVarSMYD1
MonarchSMYD1
1000_GenomesSMYD1 
Exome Variant ServerSMYD1
GNOMAD BrowserENSG00000115593
Varsome BrowserSMYD1
ACMGSMYD1 variants
VarityQ8NB12
Genomic Variants (DGV)SMYD1 [DGVbeta]
DECIPHERSMYD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSMYD1 
Mutations
ICGC Data PortalSMYD1 
TCGA Data PortalSMYD1 
Broad Tumor PortalSMYD1
OASIS PortalSMYD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSMYD1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSMYD1
Mutations and Diseases : HGMDSMYD1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSMYD1
DgiDB (Drug Gene Interaction Database)SMYD1
DoCM (Curated mutations)SMYD1
CIViC (Clinical Interpretations of Variants in Cancer)SMYD1
Cancer3DSMYD1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606846   
Orphanet
DisGeNETSMYD1
MedgenSMYD1
Genetic Testing Registry SMYD1
NextProtQ8NB12 [Medical]
GENETestsSMYD1
Target ValidationSMYD1
Huge Navigator SMYD1 [HugePedia]
ClinGenSMYD1
Clinical trials, drugs, therapy
MyCancerGenomeSMYD1
Protein Interactions : CTDSMYD1
Pharm GKB GenePA134862943
PharosQ8NB12
Clinical trialSMYD1
Miscellaneous
canSAR (ICR)SMYD1
HarmonizomeSMYD1
DataMed IndexSMYD1
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSMYD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:18 CEST 2021

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