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SNAP25 (synaptosome associated protein 25)

Identity

Alias_namesSNAP
synaptosomal-associated protein
Alias_symbol (synonym)SNAP-25
RIC-4
RIC4
SEC9
bA416N4.2
dJ1068F16.2
Other aliasCMS18
SUP
HGNC (Hugo) SNAP25
LocusID (NCBI) 6616
Atlas_Id 50575
Location 20p12.2  [Link to chromosome band 20p12]
Location_base_pair Starts at 10219003 and ends at 10307420 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LAMA3 (18q11.2) / SNAP25 (20p12.2)RASA4 (7q22.1) / SNAP25 (20p12.2)ROR1 (1p31.3) / SNAP25 (20p12.2)
SNAP25 (20p12.2) / CREBBP (16p13.3)SNAP25 (20p12.2) / EHMT1 (9q34.3)SNAP25 (20p12.2) / IGSF9B (11q25)
SNAP25 (20p12.2) / SNAP25 (20p12.2)SNRPN (15q11.2) / SNAP25 (20p12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SNAP25   11132
Cards
Entrez_Gene (NCBI)SNAP25  6616  synaptosome associated protein 25
AliasesCMS18; RIC-4; RIC4; SEC9; 
SNAP; SNAP-25; SUP; bA416N4.2; dJ1068F16.2
GeneCards (Weizmann)SNAP25
Ensembl hg19 (Hinxton)ENSG00000132639 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132639 [Gene_View]  chr20:10219003-10307420 [Contig_View]  SNAP25 [Vega]
ICGC DataPortalENSG00000132639
TCGA cBioPortalSNAP25
AceView (NCBI)SNAP25
Genatlas (Paris)SNAP25
WikiGenes6616
SOURCE (Princeton)SNAP25
Genetics Home Reference (NIH)SNAP25
Genomic and cartography
GoldenPath hg38 (UCSC)SNAP25  -     chr20:10219003-10307420 +  20p12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SNAP25  -     20p12.2   [Description]    (hg19-Feb_2009)
EnsemblSNAP25 - 20p12.2 [CytoView hg19]  SNAP25 - 20p12.2 [CytoView hg38]
Mapping of homologs : NCBISNAP25 [Mapview hg19]  SNAP25 [Mapview hg38]
OMIM600322   616330   
Gene and transcription
Genbank (Entrez)AK026732 AK090857 AK094560 AK098347 AK098767
RefSeq transcript (Entrez)NM_001322902 NM_001322903 NM_001322904 NM_001322905 NM_001322906 NM_001322907 NM_001322908 NM_001322909 NM_001322910 NM_003081 NM_130811
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SNAP25
Cluster EST : UnigeneHs.167317 [ NCBI ]
CGAP (NCI)Hs.167317
Alternative Splicing GalleryENSG00000132639
Gene ExpressionSNAP25 [ NCBI-GEO ]   SNAP25 [ EBI - ARRAY_EXPRESS ]   SNAP25 [ SEEK ]   SNAP25 [ MEM ]
Gene Expression Viewer (FireBrowse)SNAP25 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6616
GTEX Portal (Tissue expression)SNAP25
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60880   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60880  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60880
Splice isoforms : SwissVarP60880
PhosPhoSitePlusP60880
Domaine pattern : Prosite (Expaxy)T_SNARE (PS50192)   
Domains : Interpro (EBI)SNAP-25    T_SNARE_dom   
Domain families : Pfam (Sanger)SNAP-25 (PF00835)   
Domain families : Pfam (NCBI)pfam00835   
Domain families : Smart (EMBL)t_SNARE (SM00397)  
Conserved Domain (NCBI)SNAP25
DMDM Disease mutations6616
Blocks (Seattle)SNAP25
PDB (SRS)1KIL    1XTG    2N1T    3DDA    3DDB    3RK2    3RK3    3RL0    3ZUR   
PDB (PDBSum)1KIL    1XTG    2N1T    3DDA    3DDB    3RK2    3RK3    3RL0    3ZUR   
PDB (IMB)1KIL    1XTG    2N1T    3DDA    3DDB    3RK2    3RK3    3RL0    3ZUR   
PDB (RSDB)1KIL    1XTG    2N1T    3DDA    3DDB    3RK2    3RK3    3RL0    3ZUR   
Structural Biology KnowledgeBase1KIL    1XTG    2N1T    3DDA    3DDB    3RK2    3RK3    3RL0    3ZUR   
SCOP (Structural Classification of Proteins)1KIL    1XTG    2N1T    3DDA    3DDB    3RK2    3RK3    3RL0    3ZUR   
CATH (Classification of proteins structures)1KIL    1XTG    2N1T    3DDA    3DDB    3RK2    3RK3    3RL0    3ZUR   
SuperfamilyP60880
Human Protein AtlasENSG00000132639
Peptide AtlasP60880
HPRD02637
IPIIPI00010470   IPI00107625   IPI00645321   
Protein Interaction databases
DIP (DOE-UCLA)P60880
IntAct (EBI)P60880
FunCoupENSG00000132639
BioGRIDSNAP25
STRING (EMBL)SNAP25
ZODIACSNAP25
Ontologies - Pathways
QuickGOP60880
Ontology : AmiGOneurotransmitter uptake  SNAP receptor activity  protein binding  cytoplasm  trans-Golgi network  cytosol  plasma membrane  chemical synaptic transmission  neurotransmitter secretion  locomotory behavior  synaptic vesicle  voltage-gated potassium channel complex  associative learning  regulation of neuron projection development  glutamate secretion  membrane  synaptic vesicle exocytosis  synaptic vesicle docking  synaptic vesicle priming  syntaxin-1 binding  cell junction  axon  growth cone  BLOC-1 complex  SNARE complex  SNARE complex  SNARE complex  synaptic vesicle fusion to presynaptic active zone membrane  positive regulation of synaptic plasticity  vesicle  specific granule membrane  somatodendritic compartment  presynaptic membrane  neuron projection  myelin sheath  neutrophil degranulation  calcium-dependent protein binding  perinuclear region of cytoplasm  regulation of insulin secretion  long-term synaptic potentiation  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex  tertiary granule membrane  postsynapse  exocytic insertion of neurotransmitter receptor to postsynaptic membrane  neurotransmitter receptor internalization  short-term synaptic potentiation  
Ontology : EGO-EBIneurotransmitter uptake  SNAP receptor activity  protein binding  cytoplasm  trans-Golgi network  cytosol  plasma membrane  chemical synaptic transmission  neurotransmitter secretion  locomotory behavior  synaptic vesicle  voltage-gated potassium channel complex  associative learning  regulation of neuron projection development  glutamate secretion  membrane  synaptic vesicle exocytosis  synaptic vesicle docking  synaptic vesicle priming  syntaxin-1 binding  cell junction  axon  growth cone  BLOC-1 complex  SNARE complex  SNARE complex  SNARE complex  synaptic vesicle fusion to presynaptic active zone membrane  positive regulation of synaptic plasticity  vesicle  specific granule membrane  somatodendritic compartment  presynaptic membrane  neuron projection  myelin sheath  neutrophil degranulation  calcium-dependent protein binding  perinuclear region of cytoplasm  regulation of insulin secretion  long-term synaptic potentiation  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex  tertiary granule membrane  postsynapse  exocytic insertion of neurotransmitter receptor to postsynaptic membrane  neurotransmitter receptor internalization  short-term synaptic potentiation  
Pathways : BIOCARTABlockade of Neurotransmitter Relase by Botulinum Toxin [Genes]   
Pathways : KEGGSNARE interactions in vesicular transport    Synaptic vesicle cycle    Insulin secretion   
NDEx NetworkSNAP25
Atlas of Cancer Signalling NetworkSNAP25
Wikipedia pathwaysSNAP25
Orthology - Evolution
OrthoDB6616
GeneTree (enSembl)ENSG00000132639
Phylogenetic Trees/Animal Genes : TreeFamSNAP25
HOVERGENP60880
HOGENOMP60880
Homologs : HomoloGeneSNAP25
Homology/Alignments : Family Browser (UCSC)SNAP25
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSNAP25 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SNAP25
dbVarSNAP25
ClinVarSNAP25
1000_GenomesSNAP25 
Exome Variant ServerSNAP25
ExAC (Exome Aggregation Consortium)SNAP25 (select the gene name)
Genetic variants : HAPMAP6616
Genomic Variants (DGV)SNAP25 [DGVbeta]
DECIPHERSNAP25 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSNAP25 
Mutations
ICGC Data PortalSNAP25 
TCGA Data PortalSNAP25 
Broad Tumor PortalSNAP25
OASIS PortalSNAP25 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSNAP25  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSNAP25
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SNAP25
DgiDB (Drug Gene Interaction Database)SNAP25
DoCM (Curated mutations)SNAP25 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SNAP25 (select a term)
intoGenSNAP25
Cancer3DSNAP25(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600322    616330   
Orphanet13931   
MedgenSNAP25
Genetic Testing Registry SNAP25
NextProtP60880 [Medical]
TSGene6616
GENETestsSNAP25
Target ValidationSNAP25
Huge Navigator SNAP25 [HugePedia]
snp3D : Map Gene to Disease6616
BioCentury BCIQSNAP25
ClinGenSNAP25
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6616
Chemical/Pharm GKB GenePA35980
Clinical trialSNAP25
Miscellaneous
canSAR (ICR)SNAP25 (select the gene name)
Probes
Litterature
PubMed192 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSNAP25
EVEXSNAP25
GoPubMedSNAP25
iHOPSNAP25
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:32:13 CEST 2017

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