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SNCA (synuclein, alpha (non A4 component of amyloid precursor))

Identity

Other namesNACP
PARK1
PARK4
PD1
HGNC (Hugo) SNCA
LocusID (NCBI) 6622
Location 4q22.1
Location_base_pair Starts at 90645250 and ends at 90758350 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SNCA   11138
Entrez_Gene (NCBI)SNCA  6622  synuclein, alpha (non A4 component of amyloid precursor)
Cards
GeneCards (Weizmann)SNCA
Ensembl (Hinxton)ENSG00000145335 [Gene_View]  chr4:90645250-90758350 [Contig_View]  SNCA [Vega]
AceView (NCBI)SNCA
Genatlas (Paris)SNCA
SOURCE (Stanford)NM_000345 NM_001146054 NM_001146055 NM_007308
Genomic and cartography
GoldenPath (UCSC)SNCA  -  4q22.1   chr4:90645250-90758350 -  4q22.1   [Description]    (hg19-Feb_2009)
EnsemblSNCA - 4q22.1 [CytoView]
Mapping of homologs : NCBISNCA [Mapview]
OMIM127750   163890   168601   605543   
Gene and transcription
Genbank (Entrez)AI815523 AK290169 AY049786 BC013293 BC108275
RefSeq transcript (SRS)NM_000345 NM_001146054 NM_001146055 NM_007308
RefSeq transcript (Entrez)NM_000345 NM_001146054 NM_001146055 NM_007308
RefSeq genomic (SRS)AC_000136 NC_000004 NC_018915 NG_011851 NT_016354 NW_001838915 NW_004078021
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NG_011851 NT_016354 NW_001838915 NW_004078021
Consensus coding sequences : CCDS (NCBI)SNCA
Cluster EST : UnigeneHs.21374 [ SRS ] Hs.21374 [ NCBI ]
CGAP (NCI)Hs.21374
Alternative Splicing : Fast-db (Paris)GSHG0023405
Alternative Splicing GalleryENSG00000145335
Gene ExpressionSNCA [ NCBI-GEO ]   SNCA [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP37840 (SRS) P37840 (Uniprot)
NextProtP37840
With graphics : InterProP37840
Splice isoforms : SwissVarP37840(Swissvar)
Domains : Interpro (SRS)Synuclein    Synuclein_alpha   
Domains : Interpro (EBI)Synuclein    Synuclein_alpha   
Related proteins : CluSTrP37840
Domain families : Pfam (SRS)Synuclein (PF01387)   
Domain families : Pfam (Sanger)Synuclein (PF01387)   
Domain families : Pfam (NCBI)pfam01387   
DMDM6622
Blocks (Seattle)P37840
PDB (SRS)1XQ8    2JN5    2KKW    2X6M    3Q25    3Q26    3Q27    3Q28    3Q29   
PDB (PDBSum)1XQ8    2JN5    2KKW    2X6M    3Q25    3Q26    3Q27    3Q28    3Q29   
PDB (IMB)1XQ8    2JN5    2KKW    2X6M    3Q25    3Q26    3Q27    3Q28    3Q29   
PDB (RSDB)1XQ8    2JN5    2KKW    2X6M    3Q25    3Q26    3Q27    3Q28    3Q29   
Human Protein AtlasENSG00000145335
HPRD01227
IPIIPI00024107   IPI00218467   IPI00218468   IPI00964973   IPI00965305   
Protein Interaction databases
DIP (DOE-UCLA)P37840
IntAct (EBI)P37840
FunCoupENSG00000145335
REACTOMESNCA
Protein Interaction Database6622
BioGRIDSNCA
InParanoidP37840
Interologous Interaction database P37840
IntegromeDBSNCA
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SNCA
SNP (GeneSNP Utah)SNCA
SNP : HGBaseSNCA
Genetic variants : HAPMAPSNCA
Somatic Mutations in Cancer : COSMICSNCA 
CONAN: Copy Number AnalysisSNCA 
Mutations and Diseases : HGMDSNCA
OMIM127750    163890    168601    605543   
GENETests127750    163890    168601    605543   
Disease Genetic AssociationSNCA
Huge Navigator SNCA [HugePedia]  SNCA [HugeCancerGEM]
Genomic VariantsSNCA  SNCA [DGVbeta]
snp3D : Map Gene to Disease6622
General knowledge
Homologs : HomoloGeneSNCA
Homology/Alignments : Family Browser (UCSC)SNCA
Phylogenetic Trees/Animal Genes : TreeFamSNCA
Chemical/Protein Interactions : CTD6622
Chemical/Pharm GKB GenePA35986
Clinical trialSNCA
Cancer Resource (Charite)ENSG00000145335
Ontology : AmiGOmagnesium ion binding  microglial cell activation  positive regulation of receptor recycling  positive regulation of neurotransmitter secretion  fatty acid binding  copper ion binding  calcium ion binding  protein binding  extracellular region  nucleus  cytoplasm  mitochondrion  cytosol  plasma membrane  cell cortex  fatty acid metabolic process  neutral lipid metabolic process  phospholipid metabolic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  mitochondrial membrane organization  ferrous iron binding  zinc ion binding  adult locomotory behavior  response to iron(II) ion  regulation of phospholipase activity  negative regulation of platelet-derived growth factor receptor signaling pathway  regulation of glutamate secretion  regulation of dopamine secretion  actin cytoskeleton  inclusion body  oxidoreductase activity  kinesin binding  cell junction  axon  growth cone  Hsp70 protein binding  platelet alpha granule membrane  negative regulation of microtubule polymerization  receptor internalization  protein destabilization  response to magnesium ion  negative regulation of transporter activity  response to lipopolysaccharide  negative regulation of monooxygenase activity  positive regulation of peptidyl-serine phosphorylation  response to interferon-gamma  cellular response to oxidative stress  negative regulation of histone acetylation  regulation of locomotion  histone binding  dopamine biosynthetic process  response to drug  mitochondrial ATP synthesis coupled electron transport  identical protein binding  alpha-tubulin binding  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  regulation of macrophage activation  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  fibril  extracellular fibril organization  negative regulation of neuron apoptotic process  synapse  dynein binding  positive regulation of endocytosis  negative regulation of exocytosis  tau protein binding  regulation of long-term neuronal synaptic plasticity  perinuclear region of cytoplasm  synaptic vesicle endocytosis  synapse organization  regulation of acyl-CoA biosynthetic process  phosphoprotein binding  positive regulation of release of sequestered calcium ion into cytosol  dopamine uptake involved in synaptic transmission  negative regulation of dopamine uptake involved in synaptic transmission  negative regulation of serotonin uptake  negative regulation of norepinephrine uptake  calcium ion homeostasis  oxidation-reduction process  regulation of excitatory postsynaptic membrane potential  long-term synaptic potentiation  positive regulation of inositol phosphate biosynthetic process  phospholipase D inhibitor activity  negative regulation of thrombin receptor signaling pathway  response to interleukin-1  cellular response to copper ion  cellular response to epinephrine stimulus  positive regulation of protein serine/threonine kinase activity  
Ontology : EGO-EBImagnesium ion binding  microglial cell activation  positive regulation of receptor recycling  positive regulation of neurotransmitter secretion  fatty acid binding  copper ion binding  calcium ion binding  protein binding  extracellular region  nucleus  cytoplasm  mitochondrion  cytosol  plasma membrane  cell cortex  fatty acid metabolic process  neutral lipid metabolic process  phospholipid metabolic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  mitochondrial membrane organization  ferrous iron binding  zinc ion binding  adult locomotory behavior  response to iron(II) ion  regulation of phospholipase activity  negative regulation of platelet-derived growth factor receptor signaling pathway  regulation of glutamate secretion  regulation of dopamine secretion  actin cytoskeleton  inclusion body  oxidoreductase activity  kinesin binding  cell junction  axon  growth cone  Hsp70 protein binding  platelet alpha granule membrane  negative regulation of microtubule polymerization  receptor internalization  protein destabilization  response to magnesium ion  negative regulation of transporter activity  response to lipopolysaccharide  negative regulation of monooxygenase activity  positive regulation of peptidyl-serine phosphorylation  response to interferon-gamma  cellular response to oxidative stress  negative regulation of histone acetylation  regulation of locomotion  histone binding  dopamine biosynthetic process  response to drug  mitochondrial ATP synthesis coupled electron transport  identical protein binding  alpha-tubulin binding  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  regulation of macrophage activation  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  fibril  extracellular fibril organization  negative regulation of neuron apoptotic process  synapse  dynein binding  positive regulation of endocytosis  negative regulation of exocytosis  tau protein binding  regulation of long-term neuronal synaptic plasticity  perinuclear region of cytoplasm  synaptic vesicle endocytosis  synapse organization  regulation of acyl-CoA biosynthetic process  phosphoprotein binding  positive regulation of release of sequestered calcium ion into cytosol  dopamine uptake involved in synaptic transmission  negative regulation of dopamine uptake involved in synaptic transmission  negative regulation of serotonin uptake  negative regulation of norepinephrine uptake  calcium ion homeostasis  oxidation-reduction process  regulation of excitatory postsynaptic membrane potential  long-term synaptic potentiation  positive regulation of inositol phosphate biosynthetic process  phospholipase D inhibitor activity  negative regulation of thrombin receptor signaling pathway  response to interleukin-1  cellular response to copper ion  cellular response to epinephrine stimulus  positive regulation of protein serine/threonine kinase activity  
Pathways : BIOCARTAAlpha-synuclein and Parkin-mediated proteolysis in Parkinson's disease [Genes]    Role of Parkin in the Ubiquitin-Proteasomal Pathway [Genes]   
Pathways : KEGGParkinson's diseaseNeurodegenerative DisordersAlzheimer's disease
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
PubGeneSNCA
iHOPSNCA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:39:23 CEST 2013
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