SNCA (synuclein alpha)

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SNCA (synuclein alpha)

Identity

Alias (NCBI)	NACP
	PARK1
	PARK4
	PD1
HGNC (Hugo)	SNCA
HGNC Alias symb	NACP
	PD1
HGNC Alias name	non A4 component of amyloid precursor
	alpha-synuclein
	??-synuclein
HGNC Previous name	PARK1
	PARK4
HGNC Previous name	Parkinson disease (autosomal dominant, Lewy body) 4
	synuclein, alpha (non A4 component of amyloid precursor)
LocusID (NCBI)	6622
Atlas_Id	46121
Location	4q22.1 [Link to chromosome band 4q22]
Location_base_pair	Starts at 89724099 and ends at 89836976 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

APOL2 (22q12.3) / SNCA (4q22.1)

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	SNCA 11138
	Cards
Entrez_Gene (NCBI)	SNCA synuclein alpha
Aliases	NACP; PARK1; PARK4; PD1
GeneCards (Weizmann)	SNCA
Ensembl hg19 (Hinxton)	ENSG00000145335 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000145335 [Gene_View] ENSG00000145335 [Sequence] chr4:89724099-89836976 [Contig_View] SNCA [Vega]
ICGC DataPortal	ENSG00000145335
TCGA cBioPortal	SNCA
AceView (NCBI)	SNCA
Genatlas (Paris)	SNCA
SOURCE (Princeton)	SNCA
Genetics Home Reference (NIH)	SNCA
	Genomic and cartography
GoldenPath hg38 (UCSC)	SNCA - chr4:89724099-89836976 - 4q22.1 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	SNCA - 4q22.1 [Description] (hg19-Feb_2009)
GoldenPath	SNCA - 4q22.1 [CytoView hg19] SNCA - 4q22.1 [CytoView hg38]
ImmunoBase	ENSG00000145335
genome Data Viewer NCBI	SNCA [Mapview hg19]
OMIM	127750 163890 168601 605543
	Gene and transcription
Genbank (Entrez)	AI815523 AK290169 AY049786 BC013293 BC108275
RefSeq transcript (Entrez)	NM_000345 NM_001146054 NM_001146055 NM_001375285 NM_001375286 NM_001375287 NM_001375288 NM_001375290 NM_007308
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	SNCA
Alternative Splicing Gallery	ENSG00000145335
Gene Expression	SNCA [ NCBI-GEO ] SNCA [ EBI - ARRAY_EXPRESS ] SNCA [ SEEK ] SNCA [ MEM ]
Gene Expression Viewer (FireBrowse)	SNCA [ Firebrowse - Broad ]
Genevisible	Expression of SNCA in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	6622
GTEX Portal (Tissue expression)	SNCA
Human Protein Atlas	ENSG00000145335-SNCA [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P37840 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	P37840 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P37840
Splice isoforms : SwissVar	P37840
PhosPhoSitePlus	P37840
Domains : Interpro (EBI)	Synuclein Synuclein_alpha
Domain families : Pfam (Sanger)	Synuclein (PF01387)
Domain families : Pfam (NCBI)	pfam01387
Conserved Domain (NCBI)	SNCA
Blocks (Seattle)	SNCA
PDB (RSDB)	1XQ8 2JN5 2KKW 2M55 2N0A 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW 6A6B 6CT7 6CU7 6CU8 6FLT 6H6B 6I42 6L1T 6L1U 6L4S 6LRQ 6OSJ 6OSL 6OSM 6PEO 6PES 6RT0 6RTB 6SST 6SSX 6UFR 6XYO 6XYP 6XYQ
PDB Europe	1XQ8 2JN5 2KKW 2M55 2N0A 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW 6A6B 6CT7 6CU7 6CU8 6FLT 6H6B 6I42 6L1T 6L1U 6L4S 6LRQ 6OSJ 6OSL 6OSM 6PEO 6PES 6RT0 6RTB 6SST 6SSX 6UFR 6XYO 6XYP 6XYQ
PDB (PDBSum)	1XQ8 2JN5 2KKW 2M55 2N0A 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW 6A6B 6CT7 6CU7 6CU8 6FLT 6H6B 6I42 6L1T 6L1U 6L4S 6LRQ 6OSJ 6OSL 6OSM 6PEO 6PES 6RT0 6RTB 6SST 6SSX 6UFR 6XYO 6XYP 6XYQ
PDB (IMB)	1XQ8 2JN5 2KKW 2M55 2N0A 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW 6A6B 6CT7 6CU7 6CU8 6FLT 6H6B 6I42 6L1T 6L1U 6L4S 6LRQ 6OSJ 6OSL 6OSM 6PEO 6PES 6RT0 6RTB 6SST 6SSX 6UFR 6XYO 6XYP 6XYQ
Structural Biology KnowledgeBase	1XQ8 2JN5 2KKW 2M55 2N0A 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW 6A6B 6CT7 6CU7 6CU8 6FLT 6H6B 6I42 6L1T 6L1U 6L4S 6LRQ 6OSJ 6OSL 6OSM 6PEO 6PES 6RT0 6RTB 6SST 6SSX 6UFR 6XYO 6XYP 6XYQ
SCOP (Structural Classification of Proteins)	1XQ8 2JN5 2KKW 2M55 2N0A 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW 6A6B 6CT7 6CU7 6CU8 6FLT 6H6B 6I42 6L1T 6L1U 6L4S 6LRQ 6OSJ 6OSL 6OSM 6PEO 6PES 6RT0 6RTB 6SST 6SSX 6UFR 6XYO 6XYP 6XYQ
CATH (Classification of proteins structures)	1XQ8 2JN5 2KKW 2M55 2N0A 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW 6A6B 6CT7 6CU7 6CU8 6FLT 6H6B 6I42 6L1T 6L1U 6L4S 6LRQ 6OSJ 6OSL 6OSM 6PEO 6PES 6RT0 6RTB 6SST 6SSX 6UFR 6XYO 6XYP 6XYQ
Superfamily	P37840
Human Protein Atlas [tissue]	ENSG00000145335-SNCA [tissue]
Peptide Atlas	P37840
HPRD	01227
IPI	IPI00024107 IPI00218467 IPI00218468 IPI00964973 IPI00965305
	Protein Interaction databases
DIP (DOE-UCLA)	P37840
IntAct (EBI)	P37840
BioGRID	SNCA
STRING (EMBL)	SNCA
ZODIAC	SNCA
	Ontologies - Pathways
QuickGO	P37840
Ontology : AmiGO	negative regulation of transcription by RNA polymerase II SNARE binding magnesium ion binding transcription regulatory region sequence-specific DNA binding microglial cell activation positive regulation of receptor recycling actin binding protein kinase inhibitor activity fatty acid binding copper ion binding calcium ion binding protein binding phospholipid binding extracellular region extracellular region extracellular space nucleus cytoplasm cytoplasm mitochondrion lysosome cytosol cytosol plasma membrane cell cortex negative regulation of protein kinase activity apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process chemical synaptic transmission ferrous iron binding zinc ion binding response to iron(II) ion regulation of phospholipase activity negative regulation of platelet-derived growth factor receptor signaling pathway regulation of dopamine secretion actin cytoskeleton membrane synaptic vesicle exocytosis synaptic vesicle priming inclusion body oxidoreductase activity kinesin binding regulation of transmembrane transporter activity axon growth cone Hsp70 protein binding platelet alpha granule membrane negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion negative regulation of transporter activity response to lipopolysaccharide negative regulation of monooxygenase activity protein-containing complex positive regulation of peptidyl-serine phosphorylation response to interferon-gamma cellular response to oxidative stress negative regulation of histone acetylation SNARE complex assembly positive regulation of SNARE complex assembly histone binding dopamine biosynthetic process identical protein binding identical protein binding alpha-tubulin binding neuronal cell body cysteine-type endopeptidase inhibitor activity involved in apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process axon terminus cellular protein metabolic process positive regulation of endocytosis negative regulation of exocytosis positive regulation of exocytosis tau protein binding perinuclear region of cytoplasm synaptic vesicle endocytosis synaptic vesicle endocytosis positive regulation of inflammatory response synapse organization phosphoprotein binding protein tetramerization positive regulation of release of sequestered calcium ion into cytosol dopamine uptake involved in synaptic transmission negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake regulation of norepinephrine uptake negative regulation of norepinephrine uptake calcium ion homeostasis positive regulation of inositol phosphate biosynthetic process phospholipase D inhibitor activity negative regulation of thrombin-activated receptor signaling pathway response to interleukin-1 dynein complex binding cellular response to copper ion cellular response to epinephrine stimulus positive regulation of protein serine/threonine kinase activity supramolecular fiber organization supramolecular fiber regulation of neuron death negative regulation of neuron death positive regulation of neuron death negative regulation of mitochondrial electron transport, NADH to ubiquinone cuprous ion binding cuprous ion binding positive regulation of glutathione peroxidase activity positive regulation of hydrogen peroxide catabolic process regulation of synaptic vesicle recycling regulation of reactive oxygen species biosynthetic process negative regulation of chaperone-mediated autophagy regulation of presynapse assembly
Ontology : EGO-EBI	negative regulation of transcription by RNA polymerase II SNARE binding magnesium ion binding transcription regulatory region sequence-specific DNA binding microglial cell activation positive regulation of receptor recycling actin binding protein kinase inhibitor activity fatty acid binding copper ion binding calcium ion binding protein binding phospholipid binding extracellular region extracellular region extracellular space nucleus cytoplasm cytoplasm mitochondrion lysosome cytosol cytosol plasma membrane cell cortex negative regulation of protein kinase activity apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process chemical synaptic transmission ferrous iron binding zinc ion binding response to iron(II) ion regulation of phospholipase activity negative regulation of platelet-derived growth factor receptor signaling pathway regulation of dopamine secretion actin cytoskeleton membrane synaptic vesicle exocytosis synaptic vesicle priming inclusion body oxidoreductase activity kinesin binding regulation of transmembrane transporter activity axon growth cone Hsp70 protein binding platelet alpha granule membrane negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion negative regulation of transporter activity response to lipopolysaccharide negative regulation of monooxygenase activity protein-containing complex positive regulation of peptidyl-serine phosphorylation response to interferon-gamma cellular response to oxidative stress negative regulation of histone acetylation SNARE complex assembly positive regulation of SNARE complex assembly histone binding dopamine biosynthetic process identical protein binding identical protein binding alpha-tubulin binding neuronal cell body cysteine-type endopeptidase inhibitor activity involved in apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process axon terminus cellular protein metabolic process positive regulation of endocytosis negative regulation of exocytosis positive regulation of exocytosis tau protein binding perinuclear region of cytoplasm synaptic vesicle endocytosis synaptic vesicle endocytosis positive regulation of inflammatory response synapse organization phosphoprotein binding protein tetramerization positive regulation of release of sequestered calcium ion into cytosol dopamine uptake involved in synaptic transmission negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake regulation of norepinephrine uptake negative regulation of norepinephrine uptake calcium ion homeostasis positive regulation of inositol phosphate biosynthetic process phospholipase D inhibitor activity negative regulation of thrombin-activated receptor signaling pathway response to interleukin-1 dynein complex binding cellular response to copper ion cellular response to epinephrine stimulus positive regulation of protein serine/threonine kinase activity supramolecular fiber organization supramolecular fiber regulation of neuron death negative regulation of neuron death positive regulation of neuron death negative regulation of mitochondrial electron transport, NADH to ubiquinone cuprous ion binding cuprous ion binding positive regulation of glutathione peroxidase activity positive regulation of hydrogen peroxide catabolic process regulation of synaptic vesicle recycling regulation of reactive oxygen species biosynthetic process negative regulation of chaperone-mediated autophagy regulation of presynapse assembly
Pathways : BIOCARTA	Alpha-synuclein and Parkin-mediated proteolysis in Parkinson's disease [Genes] Role of Parkin in the Ubiquitin-Proteasomal Pathway [Genes]
Pathways : KEGG	Alzheimer's disease Parkinson's disease
NDEx Network	SNCA
Atlas of Cancer Signalling Network	SNCA
Wikipedia pathways	SNCA
	Orthology - Evolution
OrthoDB	6622
GeneTree (enSembl)	ENSG00000145335
Phylogenetic Trees/Animal Genes : TreeFam	SNCA
HOGENOM	P37840
Homologs : HomoloGene	SNCA
Homology/Alignments : Family Browser (UCSC)	SNCA
	Gene fusions - Rearrangements
Fusion : Quiver	SNCA
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	SNCA [hg38]
dbVar	SNCA
ClinVar	SNCA
Monarch	SNCA
1000_Genomes	SNCA
Exome Variant Server	SNCA
GNOMAD Browser	ENSG00000145335
Varsome Browser	SNCA
Genomic Variants (DGV)	SNCA [DGVbeta]
DECIPHER	SNCA [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	SNCA
	Mutations
ICGC Data Portal	SNCA
TCGA Data Portal	SNCA
Broad Tumor Portal	SNCA
OASIS Portal	SNCA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	SNCA [overview] [genome browser] [tissue] [distribution]
Somatic Mutations in Cancer : COSMIC3D	SNCA
Mutations and Diseases : HGMD	SNCA
LOVD (Leiden Open Variation Database)	Parkinson's disease Mutation Database
BioMuta	search SNCA
DgiDB (Drug Gene Interaction Database)	SNCA
DoCM (Curated mutations)	SNCA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	SNCA (select a term)
intoGen	SNCA
Cancer3D	SNCA(select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	127750 163890 168601 605543
Orphanet	17928 932 23022
DisGeNET	SNCA
Medgen	SNCA
Genetic Testing Registry	SNCA
NextProt	P37840 [Medical]
GENETests	SNCA
Target Validation	SNCA
Huge Navigator	SNCA [HugePedia]
ClinGen	SNCA
	Clinical trials, drugs, therapy
MyCancerGenome	SNCA
Protein Interactions : CTD
Pharm GKB Gene	PA35986
Pharos	P37840
Clinical trial	SNCA
	Miscellaneous
canSAR (ICR)	SNCA (select the gene name)
Harmonizome	SNCA
DataMed Index	SNCA
	Probes
	Litterature
PubMed	499 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
EVEX	SNCA

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Thu Mar 25 19:46:49 CET 2021

Home Genes Leukemias Solid Tumors Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

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jlhuret@AtlasGeneticsOncology.org.

Atlas of Genetics and Cytogenetics in Oncology and Haematology

SNCA (synuclein alpha)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute