Identity
HGNC
LOCATION
4q22.1
LOCUSID
ALIAS
NACP,PARK1,PARK4,PD1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6622
MIM: 163890
HGNC: 11138
Ensembl: ENSG00000145335
Variants:
dbSNP: 6622
ClinVar: 6622
TCGA: ENSG00000145335
COSMIC: SNCA
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35657577 | 2024 | Disease Mechanisms of Multiple System Atrophy: What a Parallel Between the Form of Pasta and the Alpha-Synuclein Assemblies Involved in MSA and PD Tells Us. | 0 |
| 37671615 | 2024 | MerTK is a mediator of alpha-synuclein fibril uptake by human microglia. | 1 |
| 37714326 | 2024 | Calcium influx: An essential process by which α-Synuclein regulates morphology of erythrocytes. | 1 |
| 37995510 | 2024 | Selenium and selenoproteins role in Parkinson's disease: Is there a link between selenoproteins and accumulated alpha-synuclein? | 0 |
| 38043677 | 2024 | Young human alpha synuclein transgenic (BAC-SNCA) mice display sex- and gene-dose-dependent phenotypic disturbances. | 0 |
| 38048087 | 2024 | Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease. | 8 |
| 38104957 | 2024 | Revisiting the role of 3-nitrotyrosine residues in the formation of alpha-synuclein oligomers and fibrils. | 0 |
| 38105619 | 2024 | Alpha-synuclein promotes PRMT5-mediated H4R3me2s histone methylation by interacting with the BAF complex. | 1 |
| 38163647 | 2024 | Extracellular α-synuclein impairs sphingosine 1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D in HeLa cells. | 0 |
| 38250774 | 2024 | Misfolded α-Synuclein in Autosomal Dominant Alzheimer's Disease. | 0 |
| 38256207 | 2024 | The 75-99 C-Terminal Peptide of URG7 Protein Promotes α-Synuclein Disaggregation. | 0 |
| 38270442 | 2024 | Misfolded alpha-synuclein in amyotrophic lateral sclerosis: Implications for diagnosis and treatment. | 1 |
| 38291230 | 2024 | Dopaminergic neuron loss in mice due to increased levels of wild-type human α-Synuclein only takes place under conditions of accelerated aging. | 0 |
| 38307302 | 2024 | Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease. | 2 |
| 38335281 | 2024 | Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons. | 1 |
Citation
Dessen P
SNCA (synuclein alpha)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46121/snca
