Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SNCA (synuclein alpha)

Identity

Alias (NCBI)NACP
PARK1
PARK4
PD1
HGNC (Hugo) SNCA
HGNC Alias symbNACP
PD1
HGNC Alias namenon A4 component of amyloid precursor
 alpha-synuclein
 ??-synuclein
HGNC Previous namePARK1
 PARK4
HGNC Previous nameParkinson disease (autosomal dominant, Lewy body) 4
 synuclein, alpha (non A4 component of amyloid precursor)
LocusID (NCBI) 6622
Atlas_Id 46121
Location 4q22.1  [Link to chromosome band 4q22]
Location_base_pair Starts at 89724099 and ends at 89836976 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
APOL2 (22q12.3) / SNCA (4q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SNCA   11138
Cards
Entrez_Gene (NCBI)SNCA  6622  synuclein alpha
AliasesNACP; PARK1; PARK4; PD1
GeneCards (Weizmann)SNCA
Ensembl hg19 (Hinxton)ENSG00000145335 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145335 [Gene_View]  ENSG00000145335 [Sequence]  chr4:89724099-89836976 [Contig_View]  SNCA [Vega]
ICGC DataPortalENSG00000145335
TCGA cBioPortalSNCA
AceView (NCBI)SNCA
Genatlas (Paris)SNCA
WikiGenes6622
SOURCE (Princeton)SNCA
Genetics Home Reference (NIH)SNCA
Genomic and cartography
GoldenPath hg38 (UCSC)SNCA  -     chr4:89724099-89836976 -  4q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SNCA  -     4q22.1   [Description]    (hg19-Feb_2009)
GoldenPathSNCA - 4q22.1 [CytoView hg19]  SNCA - 4q22.1 [CytoView hg38]
ImmunoBaseENSG00000145335
genome Data Viewer NCBISNCA [Mapview hg19]  
OMIM127750   163890   168601   605543   
Gene and transcription
Genbank (Entrez)AI815523 AK290169 AY049786 BC013293 BC108275
RefSeq transcript (Entrez)NM_000345 NM_001146054 NM_001146055 NM_001375285 NM_001375286 NM_001375287 NM_001375288 NM_001375290 NM_007308
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SNCA
Alternative Splicing GalleryENSG00000145335
Gene ExpressionSNCA [ NCBI-GEO ]   SNCA [ EBI - ARRAY_EXPRESS ]   SNCA [ SEEK ]   SNCA [ MEM ]
Gene Expression Viewer (FireBrowse)SNCA [ Firebrowse - Broad ]
GenevisibleExpression of SNCA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6622
GTEX Portal (Tissue expression)SNCA
Human Protein AtlasENSG00000145335-SNCA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP37840   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP37840  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP37840
Splice isoforms : SwissVarP37840
PhosPhoSitePlusP37840
Domains : Interpro (EBI)Synuclein    Synuclein_alpha   
Domain families : Pfam (Sanger)Synuclein (PF01387)   
Domain families : Pfam (NCBI)pfam01387   
Conserved Domain (NCBI)SNCA
DMDM Disease mutations6622
Blocks (Seattle)SNCA
PDB (RSDB)1XQ8    2JN5    2KKW    2M55    2N0A    2X6M    3Q25    3Q26    3Q27    3Q28    3Q29    4BXL    4R0U    4R0W    4RIK    4RIL    4ZNN    5CRW    6A6B    6CT7    6CU7    6CU8    6FLT    6H6B    6OSJ    6OSL    6OSM    6PEO    6PES    6RT0    6RTB    6SST    6SSX   
PDB Europe1XQ8    2JN5    2KKW    2M55    2N0A    2X6M    3Q25    3Q26    3Q27    3Q28    3Q29    4BXL    4R0U    4R0W    4RIK    4RIL    4ZNN    5CRW    6A6B    6CT7    6CU7    6CU8    6FLT    6H6B    6OSJ    6OSL    6OSM    6PEO    6PES    6RT0    6RTB    6SST    6SSX   
PDB (PDBSum)1XQ8    2JN5    2KKW    2M55    2N0A    2X6M    3Q25    3Q26    3Q27    3Q28    3Q29    4BXL    4R0U    4R0W    4RIK    4RIL    4ZNN    5CRW    6A6B    6CT7    6CU7    6CU8    6FLT    6H6B    6OSJ    6OSL    6OSM    6PEO    6PES    6RT0    6RTB    6SST    6SSX   
PDB (IMB)1XQ8    2JN5    2KKW    2M55    2N0A    2X6M    3Q25    3Q26    3Q27    3Q28    3Q29    4BXL    4R0U    4R0W    4RIK    4RIL    4ZNN    5CRW    6A6B    6CT7    6CU7    6CU8    6FLT    6H6B    6OSJ    6OSL    6OSM    6PEO    6PES    6RT0    6RTB    6SST    6SSX   
Structural Biology KnowledgeBase1XQ8    2JN5    2KKW    2M55    2N0A    2X6M    3Q25    3Q26    3Q27    3Q28    3Q29    4BXL    4R0U    4R0W    4RIK    4RIL    4ZNN    5CRW    6A6B    6CT7    6CU7    6CU8    6FLT    6H6B    6OSJ    6OSL    6OSM    6PEO    6PES    6RT0    6RTB    6SST    6SSX   
SCOP (Structural Classification of Proteins)1XQ8    2JN5    2KKW    2M55    2N0A    2X6M    3Q25    3Q26    3Q27    3Q28    3Q29    4BXL    4R0U    4R0W    4RIK    4RIL    4ZNN    5CRW    6A6B    6CT7    6CU7    6CU8    6FLT    6H6B    6OSJ    6OSL    6OSM    6PEO    6PES    6RT0    6RTB    6SST    6SSX   
CATH (Classification of proteins structures)1XQ8    2JN5    2KKW    2M55    2N0A    2X6M    3Q25    3Q26    3Q27    3Q28    3Q29    4BXL    4R0U    4R0W    4RIK    4RIL    4ZNN    5CRW    6A6B    6CT7    6CU7    6CU8    6FLT    6H6B    6OSJ    6OSL    6OSM    6PEO    6PES    6RT0    6RTB    6SST    6SSX   
SuperfamilyP37840
Human Protein Atlas [tissue]ENSG00000145335-SNCA [tissue]
Peptide AtlasP37840
HPRD01227
IPIIPI00024107   IPI00218467   IPI00218468   IPI00964973   IPI00965305   
Protein Interaction databases
DIP (DOE-UCLA)P37840
IntAct (EBI)P37840
FunCoupENSG00000145335
BioGRIDSNCA
STRING (EMBL)SNCA
ZODIACSNCA
Ontologies - Pathways
QuickGOP37840
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  SNARE binding  magnesium ion binding  transcription regulatory region sequence-specific DNA binding  microglial cell activation  positive regulation of receptor recycling  actin binding  protein kinase inhibitor activity  fatty acid binding  copper ion binding  calcium ion binding  protein binding  phospholipid binding  extracellular region  extracellular region  extracellular space  nucleus  cytoplasm  mitochondrion  lysosome  cytosol  cytosol  plasma membrane  cell cortex  negative regulation of protein kinase activity  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  ferrous iron binding  zinc ion binding  response to iron(II) ion  regulation of phospholipase activity  negative regulation of platelet-derived growth factor receptor signaling pathway  regulation of dopamine secretion  actin cytoskeleton  membrane  synaptic vesicle exocytosis  synaptic vesicle priming  inclusion body  oxidoreductase activity  kinesin binding  regulation of transmembrane transporter activity  axon  growth cone  Hsp70 protein binding  platelet alpha granule membrane  negative regulation of microtubule polymerization  receptor internalization  protein destabilization  response to magnesium ion  negative regulation of transporter activity  response to lipopolysaccharide  negative regulation of monooxygenase activity  protein-containing complex  positive regulation of peptidyl-serine phosphorylation  response to interferon-gamma  cellular response to oxidative stress  negative regulation of histone acetylation  SNARE complex assembly  positive regulation of SNARE complex assembly  histone binding  dopamine biosynthetic process  identical protein binding  identical protein binding  alpha-tubulin binding  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  cellular protein metabolic process  positive regulation of endocytosis  negative regulation of exocytosis  positive regulation of exocytosis  tau protein binding  perinuclear region of cytoplasm  synaptic vesicle endocytosis  positive regulation of inflammatory response  phosphoprotein binding  protein tetramerization  positive regulation of release of sequestered calcium ion into cytosol  dopamine uptake involved in synaptic transmission  negative regulation of dopamine uptake involved in synaptic transmission  negative regulation of serotonin uptake  regulation of norepinephrine uptake  negative regulation of norepinephrine uptake  calcium ion homeostasis  oxidation-reduction process  positive regulation of inositol phosphate biosynthetic process  phospholipase D inhibitor activity  negative regulation of thrombin-activated receptor signaling pathway  response to interleukin-1  dynein complex binding  cellular response to copper ion  cellular response to epinephrine stimulus  positive regulation of protein serine/threonine kinase activity  supramolecular fiber organization  presynapse  supramolecular fiber  negative regulation of neuron death  positive regulation of neuron death  negative regulation of mitochondrial electron transport, NADH to ubiquinone  cuprous ion binding  positive regulation of glutathione peroxidase activity  positive regulation of hydrogen peroxide catabolic process  regulation of synaptic vesicle recycling  regulation of reactive oxygen species biosynthetic process  negative regulation of chaperone-mediated autophagy  regulation of presynapse assembly  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  SNARE binding  magnesium ion binding  transcription regulatory region sequence-specific DNA binding  microglial cell activation  positive regulation of receptor recycling  actin binding  protein kinase inhibitor activity  fatty acid binding  copper ion binding  calcium ion binding  protein binding  phospholipid binding  extracellular region  extracellular region  extracellular space  nucleus  cytoplasm  mitochondrion  lysosome  cytosol  cytosol  plasma membrane  cell cortex  negative regulation of protein kinase activity  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  ferrous iron binding  zinc ion binding  response to iron(II) ion  regulation of phospholipase activity  negative regulation of platelet-derived growth factor receptor signaling pathway  regulation of dopamine secretion  actin cytoskeleton  membrane  synaptic vesicle exocytosis  synaptic vesicle priming  inclusion body  oxidoreductase activity  kinesin binding  regulation of transmembrane transporter activity  axon  growth cone  Hsp70 protein binding  platelet alpha granule membrane  negative regulation of microtubule polymerization  receptor internalization  protein destabilization  response to magnesium ion  negative regulation of transporter activity  response to lipopolysaccharide  negative regulation of monooxygenase activity  protein-containing complex  positive regulation of peptidyl-serine phosphorylation  response to interferon-gamma  cellular response to oxidative stress  negative regulation of histone acetylation  SNARE complex assembly  positive regulation of SNARE complex assembly  histone binding  dopamine biosynthetic process  identical protein binding  identical protein binding  alpha-tubulin binding  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  cellular protein metabolic process  positive regulation of endocytosis  negative regulation of exocytosis  positive regulation of exocytosis  tau protein binding  perinuclear region of cytoplasm  synaptic vesicle endocytosis  positive regulation of inflammatory response  phosphoprotein binding  protein tetramerization  positive regulation of release of sequestered calcium ion into cytosol  dopamine uptake involved in synaptic transmission  negative regulation of dopamine uptake involved in synaptic transmission  negative regulation of serotonin uptake  regulation of norepinephrine uptake  negative regulation of norepinephrine uptake  calcium ion homeostasis  oxidation-reduction process  positive regulation of inositol phosphate biosynthetic process  phospholipase D inhibitor activity  negative regulation of thrombin-activated receptor signaling pathway  response to interleukin-1  dynein complex binding  cellular response to copper ion  cellular response to epinephrine stimulus  positive regulation of protein serine/threonine kinase activity  supramolecular fiber organization  presynapse  supramolecular fiber  negative regulation of neuron death  positive regulation of neuron death  negative regulation of mitochondrial electron transport, NADH to ubiquinone  cuprous ion binding  positive regulation of glutathione peroxidase activity  positive regulation of hydrogen peroxide catabolic process  regulation of synaptic vesicle recycling  regulation of reactive oxygen species biosynthetic process  negative regulation of chaperone-mediated autophagy  regulation of presynapse assembly  
Pathways : KEGGAlzheimer's disease    Parkinson's disease   
NDEx NetworkSNCA
Atlas of Cancer Signalling NetworkSNCA
Wikipedia pathwaysSNCA
Orthology - Evolution
OrthoDB6622
GeneTree (enSembl)ENSG00000145335
Phylogenetic Trees/Animal Genes : TreeFamSNCA
HOGENOMP37840
Homologs : HomoloGeneSNCA
Homology/Alignments : Family Browser (UCSC)SNCA
Gene fusions - Rearrangements
Fusion : QuiverSNCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSNCA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SNCA
dbVarSNCA
ClinVarSNCA
MonarchSNCA
1000_GenomesSNCA 
Exome Variant ServerSNCA
GNOMAD BrowserENSG00000145335
Varsome BrowserSNCA
Genetic variants : HAPMAP6622
Genomic Variants (DGV)SNCA [DGVbeta]
DECIPHERSNCA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSNCA 
Mutations
ICGC Data PortalSNCA 
TCGA Data PortalSNCA 
Broad Tumor PortalSNCA
OASIS PortalSNCA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSNCA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSNCA
Mutations and Diseases : HGMDSNCA
LOVD (Leiden Open Variation Database)Parkinson's disease Mutation Database
BioMutasearch SNCA
DgiDB (Drug Gene Interaction Database)SNCA
DoCM (Curated mutations)SNCA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SNCA (select a term)
intoGenSNCA
Cancer3DSNCA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM127750    163890    168601    605543   
Orphanet17928    932    23022   
DisGeNETSNCA
MedgenSNCA
Genetic Testing Registry SNCA
NextProtP37840 [Medical]
TSGene6622
GENETestsSNCA
Target ValidationSNCA
Huge Navigator SNCA [HugePedia]
snp3D : Map Gene to Disease6622
BioCentury BCIQSNCA
ClinGenSNCA
Clinical trials, drugs, therapy
Protein Interactions : CTD6622
Pharm GKB GenePA35986
Clinical trialSNCA
Miscellaneous
canSAR (ICR)SNCA (select the gene name)
HarmonizomeSNCA
DataMed IndexSNCA
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSNCA
EVEXSNCA
GoPubMedSNCA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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