SNCA (synuclein alpha)

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SNCA (synuclein alpha)

Identity

Other names	NACP
	PARK1
	PARK4
	PD1
HGNC (Hugo)	SNCA
LocusID (NCBI)	6622
Atlas_Id	46121
Location	4q22.1 [Link to chromosome band 4q22]
Location_base_pair	Starts at 90645250 and ends at 90758350 bp from pter ( according to hg19-Feb_2009)

Fusion genes
(updated 2016)

APOL2 (22q12.3) / SNCA (4q22.1)

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	SNCA 11138
	Cards
Entrez_Gene (NCBI)	SNCA 6622 synuclein alpha
Aliases	NACP; PARK1; PARK4; PD1
GeneCards (Weizmann)	SNCA
Ensembl hg19 (Hinxton)	ENSG00000145335 [Gene_View] chr4:90645250-90758350 [Contig_View] SNCA [Vega]
Ensembl hg38 (Hinxton)	ENSG00000145335 [Gene_View] chr4:90645250-90758350 [Contig_View] SNCA [Vega]
ICGC DataPortal	ENSG00000145335
TCGA cBioPortal	SNCA
AceView (NCBI)	SNCA
Genatlas (Paris)	SNCA
WikiGenes	6622
SOURCE (Princeton)	SNCA
	Genomic and cartography
GoldenPath hg19 (UCSC)	SNCA - chr4:90645250-90758350 - 4q22.1 [Description] (hg19-Feb_2009)
GoldenPath hg38 (UCSC)	SNCA - 4q22.1 [Description] (hg38-Dec_2013)
Ensembl	SNCA - 4q22.1 [CytoView hg19] SNCA - 4q22.1 [CytoView hg38]
Mapping of homologs : NCBI	SNCA [Mapview hg19] SNCA [Mapview hg38]
OMIM	127750 163890 168601 605543
	Gene and transcription
Genbank (Entrez)	AI815523 AK290169 AY049786 BC013293 BC108275
RefSeq transcript (Entrez)	NM_000345 NM_001146054 NM_001146055 NM_007308
RefSeq genomic (Entrez)	NC_000004 NC_018915 NG_011851 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)	SNCA
Cluster EST : Unigene	Hs.21374 [ NCBI ]
CGAP (NCI)	Hs.21374
Alternative Splicing Gallery	ENSG00000145335
Gene Expression	SNCA [ NCBI-GEO ] SNCA [ EBI - ARRAY_EXPRESS ] SNCA [ SEEK ] SNCA [ MEM ]
Gene Expression Viewer (FireBrowse)	SNCA [ Firebrowse - Broad ]
SOURCE (Princeton)	Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
Genevisible	Expression in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	6622
GTEX Portal (Tissue expression)	SNCA
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P37840 (Uniprot)
NextProt	P37840 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P37840
Splice isoforms : SwissVar	P37840 (Swissvar)
PhosPhoSitePlus	P37840
Domains : Interpro (EBI)	Synuclein Synuclein_alpha
Domain families : Pfam (Sanger)	Synuclein (PF01387)
Domain families : Pfam (NCBI)	pfam01387
DMDM Disease mutations	6622
Blocks (Seattle)	SNCA
PDB (SRS)	1XQ8 2JN5 2KKW 2M55 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW
PDB (PDBSum)	1XQ8 2JN5 2KKW 2M55 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW
PDB (IMB)	1XQ8 2JN5 2KKW 2M55 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW
PDB (RSDB)	1XQ8 2JN5 2KKW 2M55 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW
Structural Biology KnowledgeBase	1XQ8 2JN5 2KKW 2M55 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW
SCOP (Structural Classification of Proteins)	1XQ8 2JN5 2KKW 2M55 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW
CATH (Classification of proteins structures)	1XQ8 2JN5 2KKW 2M55 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW
Superfamily	P37840
Human Protein Atlas	ENSG00000145335
Peptide Atlas	P37840
HPRD	01227
IPI	IPI00024107 IPI00218467 IPI00218468 IPI00964973 IPI00965305
	Protein Interaction databases
DIP (DOE-UCLA)	P37840
IntAct (EBI)	P37840
FunCoup	ENSG00000145335
BioGRID	SNCA
STRING (EMBL)	SNCA
ZODIAC	SNCA
	Ontologies - Pathways
QuickGO	P37840
Ontology : AmiGO	negative regulation of transcription from RNA polymerase II promoter magnesium ion binding microglial cell activation positive regulation of receptor recycling negative regulation of protein phosphorylation positive regulation of neurotransmitter secretion fatty acid binding copper ion binding calcium ion binding protein binding phospholipid binding extracellular region extracellular region extracellular space nucleus nuclear outer membrane cytoplasm mitochondrion mitochondrial respiratory chain complex I lysosome rough endoplasmic reticulum Golgi apparatus cytosol cytosol ribosome plasma membrane cell cortex fatty acid metabolic process neutral lipid metabolic process phospholipid metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process mitochondrial membrane organization aging microtubule binding synaptic vesicle ferrous iron binding zinc ion binding adult locomotory behavior response to iron(II) ion regulation of phospholipase activity negative regulation of platelet-derived growth factor receptor signaling pathway regulation of glutamate secretion regulation of dopamine secretion actin cytoskeleton membrane inclusion body oxidoreductase activity kinesin binding protein domain specific binding cell junction axon growth cone platelet alpha granule membrane negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion negative regulation of transporter activity response to lipopolysaccharide negative regulation of monooxygenase activity positive regulation of peptidyl-serine phosphorylation response to interferon-gamma cellular response to oxidative stress negative regulation of histone acetylation regulation of locomotion histone binding dopamine biosynthetic process response to drug mitochondrial ATP synthesis coupled electron transport identical protein binding identical protein binding alpha-tubulin binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process regulation of macrophage activation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process terminal bouton fibril extracellular fibril organization phospholipase binding negative regulation of neuron apoptotic process transcription regulatory region DNA binding cellular protein metabolic process cellular response to fibroblast growth factor stimulus dynein binding positive regulation of endocytosis negative regulation of exocytosis negative regulation of dopamine metabolic process protein N-terminus binding behavioral response to cocaine tau protein binding regulation of long-term neuronal synaptic plasticity perinuclear region of cytoplasm beta-tubulin binding synaptic vesicle endocytosis synapse organization regulation of acyl-CoA biosynthetic process phosphoprotein binding positive regulation of release of sequestered calcium ion into cytosol dopamine uptake involved in synaptic transmission negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake negative regulation of norepinephrine uptake calcium ion homeostasis oxidation-reduction process excitatory postsynaptic potential long-term synaptic potentiation positive regulation of inositol phosphate biosynthetic process phospholipase D inhibitor activity negative regulation of thrombin receptor signaling pathway response to interleukin-1 cellular response to copper ion cellular response to epinephrine stimulus positive regulation of protein serine/threonine kinase activity postsynapse negative regulation of neuron death negative regulation of mitochondrial electron transport, NADH to ubiquinone positive regulation of glutathione peroxidase activity positive regulation of hydrogen peroxide catabolic process regulation of synaptic vesicle recycling regulation of reactive oxygen species biosynthetic process negative regulation of chaperone-mediated autophagy
Ontology : EGO-EBI	negative regulation of transcription from RNA polymerase II promoter magnesium ion binding microglial cell activation positive regulation of receptor recycling negative regulation of protein phosphorylation positive regulation of neurotransmitter secretion fatty acid binding copper ion binding calcium ion binding protein binding phospholipid binding extracellular region extracellular region extracellular space nucleus nuclear outer membrane cytoplasm mitochondrion mitochondrial respiratory chain complex I lysosome rough endoplasmic reticulum Golgi apparatus cytosol cytosol ribosome plasma membrane cell cortex fatty acid metabolic process neutral lipid metabolic process phospholipid metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process mitochondrial membrane organization aging microtubule binding synaptic vesicle ferrous iron binding zinc ion binding adult locomotory behavior response to iron(II) ion regulation of phospholipase activity negative regulation of platelet-derived growth factor receptor signaling pathway regulation of glutamate secretion regulation of dopamine secretion actin cytoskeleton membrane inclusion body oxidoreductase activity kinesin binding protein domain specific binding cell junction axon growth cone platelet alpha granule membrane negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion negative regulation of transporter activity response to lipopolysaccharide negative regulation of monooxygenase activity positive regulation of peptidyl-serine phosphorylation response to interferon-gamma cellular response to oxidative stress negative regulation of histone acetylation regulation of locomotion histone binding dopamine biosynthetic process response to drug mitochondrial ATP synthesis coupled electron transport identical protein binding identical protein binding alpha-tubulin binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process regulation of macrophage activation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process terminal bouton fibril extracellular fibril organization phospholipase binding negative regulation of neuron apoptotic process transcription regulatory region DNA binding cellular protein metabolic process cellular response to fibroblast growth factor stimulus dynein binding positive regulation of endocytosis negative regulation of exocytosis negative regulation of dopamine metabolic process protein N-terminus binding behavioral response to cocaine tau protein binding regulation of long-term neuronal synaptic plasticity perinuclear region of cytoplasm beta-tubulin binding synaptic vesicle endocytosis synapse organization regulation of acyl-CoA biosynthetic process phosphoprotein binding positive regulation of release of sequestered calcium ion into cytosol dopamine uptake involved in synaptic transmission negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake negative regulation of norepinephrine uptake calcium ion homeostasis oxidation-reduction process excitatory postsynaptic potential long-term synaptic potentiation positive regulation of inositol phosphate biosynthetic process phospholipase D inhibitor activity negative regulation of thrombin receptor signaling pathway response to interleukin-1 cellular response to copper ion cellular response to epinephrine stimulus positive regulation of protein serine/threonine kinase activity postsynapse negative regulation of neuron death negative regulation of mitochondrial electron transport, NADH to ubiquinone positive regulation of glutathione peroxidase activity positive regulation of hydrogen peroxide catabolic process regulation of synaptic vesicle recycling regulation of reactive oxygen species biosynthetic process negative regulation of chaperone-mediated autophagy
Pathways : BIOCARTA	Alpha-synuclein and Parkin-mediated proteolysis in Parkinson's disease [Genes] Role of Parkin in the Ubiquitin-Proteasomal Pathway [Genes]
Pathways : KEGG	Alzheimer's disease Parkinson's disease
NDEx Network	SNCA
Atlas of Cancer Signalling Network	SNCA
Wikipedia pathways	SNCA
	Orthology - Evolution
OrthoDB	6622
GeneTree (enSembl)	ENSG00000145335
Phylogenetic Trees/Animal Genes : TreeFam	SNCA
Homologs : HomoloGene	SNCA
Homology/Alignments : Family Browser (UCSC)	SNCA
	Gene fusions - Rearrangements
	Polymorphisms : SNP, variants
NCBI Variation Viewer	SNCA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	SNCA
dbVar	SNCA
ClinVar	SNCA
1000_Genomes	SNCA
Exome Variant Server	SNCA
ExAC (Exome Aggregation Consortium)	SNCA (select the gene name)
Genetic variants : HAPMAP	6622
Genomic Variants (DGV)	SNCA [DGVbeta]
	Mutations
ICGC Data Portal	SNCA
TCGA Data Portal	SNCA
Broad Tumor Portal	SNCA
OASIS Portal	SNCA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	SNCA
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)	Parkinson's disease Mutation Database
BioMuta	search SNCA
DgiDB (Drug Gene Interaction Database)	SNCA
DoCM (Curated mutations)	SNCA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	SNCA (select a term)
intoGen	SNCA
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor]
	Diseases
DECIPHER (Syndromes)	4:90645250-90758350 ENSG00000145335
CONAN: Copy Number Analysis	SNCA
Mutations and Diseases : HGMD	SNCA
OMIM	127750 163890 168601 605543
Medgen	SNCA
Genetic Testing Registry	SNCA
NextProt	P37840 [Medical]
TSGene	6622
GENETests	SNCA
Huge Navigator	SNCA [HugePedia]
snp3D : Map Gene to Disease	6622
BioCentury BCIQ	SNCA
ClinGen	SNCA
	Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD	6622
Chemical/Pharm GKB Gene	PA35986
Clinical trial	SNCA
	Miscellaneous
canSAR (ICR)	SNCA (select the gene name)
	Probes
	Litterature
PubMed	499 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	SNCA
EVEX	SNCA
GoPubMed	SNCA
iHOP	SNCA

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Mon Sep 19 19:14:13 CEST 2016

Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

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jlhuret@AtlasGeneticsOncology.org.

Atlas of Genetics and Cytogenetics in Oncology and Haematology

SNCA (synuclein alpha)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute