SND1 (staphylococcal nuclease and tudor domain containing 1)

2007-12-01  

Identity

HGNC
LOCATION
7q32.1
LOCUSID
ALIAS
TDRD11,Tudor-SN,p100
FUSION GENES

Other Information

Locus ID:

NCBI: 27044
MIM: 602181
HGNC: 30646
Ensembl: ENSG00000197157

Variants:

dbSNP: 27044
ClinVar: 27044
TCGA: ENSG00000197157
COSMIC: SND1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197157ENST00000354725Q7KZF4
ENSG00000197157ENST00000354725A0A140VK49
ENSG00000197157ENST00000486037H7C597

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
122349342002Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II.59
223965372012Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor κB and miR-221.53
214781472011Identification of staphylococcal nuclease domain-containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions.49
175766642007Transcriptional co-activator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome.44
179090682007SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis.44
249817412014MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.40
156958022005The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6.39
184536312008Structural and functional insights into human Tudor-SN, a key component linking RNA interference and editing.38

Citation

Dessen P

SND1 (staphylococcal nuclease and tudor domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49890/snd1