SNIP1 (Smad nuclear interacting protein 1)

2008-12-01  

Identity

HGNC
SNIP1
LOCATION
1p34.3
LOCUSID
79753
ALIAS
PML1,PMRED
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79753
MIM: 608241
HGNC: 30587
Ensembl: ENSG00000163877

Variants:

dbSNP: 79753
ClinVar: 79753
TCGA: ENSG00000163877
COSMIC: SNIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163877ENST00000296215Q8TAD8
ENSG00000163877ENST00000296215B1AK66
ENSG00000163877ENST00000468040A0A1W2PRA0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
186325812008The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis.98
222795242012Genetic mapping and exome sequencing identify variants associated with five novel diseases.97
187941512008Regulation of cyclin D1 RNA stability by SNIP1.38
211677682011Hypoxia-inducible factor-1 alpha, in association with TWIST2 and SNIP1, is a critical prognostic factor in patients with tongue squamous cell carcinoma.26
171572592006SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes.25
157506222005Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP.21
153780062004The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression.14
277030032016SUMO Modification Reverses Inhibitory Effects of Smad Nuclear Interacting Protein-1 in TGF-β Responses.4
304040042018SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.3
309545902019Overexpression of miR-335 inhibits the migration and invasion of osteosarcoma by targeting SNIP1.3

Citation

Dessen P

SNIP1 (Smad nuclear interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50509/snip1