SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70)

2003-11-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
RNPU1Z,RPU1,SNRP70,Snp1,U1-70K,U170K,U1AP,U1RNP
FUSION GENES

Other Information

Locus ID:

NCBI: 6625
MIM: 180740
HGNC: 11150
Ensembl: ENSG00000104852

Variants:

dbSNP: 6625
ClinVar: 6625
TCGA: ENSG00000104852
COSMIC: SNRNP70

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104852ENST00000221448P08621
ENSG00000104852ENST00000401730P08621
ENSG00000104852ENST00000595231P08621
ENSG00000104852ENST00000598441P08621
ENSG00000104852ENST00000598441A0A024QZD5
ENSG00000104852ENST00000598984M0QYR1
ENSG00000104852ENST00000601065P08621
ENSG00000104852ENST00000601411M0QX04

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, U1-snRNPKEGGhsa_M00351
Spliceosome, U1-snRNPKEGGM00351
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
240230612013U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease.82
240230612013U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease.82
215369042011Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly.71
255551582015Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.64
261240922015FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP.28
224908662012U1-small nuclear ribonucleoprotein activates the NLRP3 inflammasome in human monocytes.27
268289622016A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange.25
205195842010Splicing-independent recruitment of U1 snRNP to a transcription unit in living cells.24
238742162013The conserved intronic cleavage and polyadenylation site of CstF-77 gene imparts control of 3' end processing activity through feedback autoregulation and by U1 snRNP.21
176225842007Pre-spliceosomal binding of U1 small nuclear ribonucleoprotein (RNP) and heterogenous nuclear RNP E1 is associated with suppression of a growth hormone receptor pseudoexon.18

Citation

Dessen P

SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42344/snrnp70