SNRPA (small nuclear ribonucleoprotein polypeptide A)

2016-10-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
Mud1,U1-A,U1A
FUSION GENES

Other Information

Locus ID:

NCBI: 6626
MIM: 182285
HGNC: 11151
Ensembl: ENSG00000077312

Variants:

dbSNP: 6626
ClinVar: 6626
TCGA: ENSG00000077312
COSMIC: SNRPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077312ENST00000243563P09012
ENSG00000077312ENST00000597353M0R2B8
ENSG00000077312ENST00000599362M0R221
ENSG00000077312ENST00000600456M0R0G9
ENSG00000077312ENST00000601253M0QXK2
ENSG00000077312ENST00000601393M0R268
ENSG00000077312ENST00000601545M0QZG7

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, U1-snRNPKEGGhsa_M00351
Spliceosome, U1-snRNPKEGGM00351
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
175076592007Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3'-UTR.45
15890361200513C NMR relaxation studies of RNA base and ribose nuclei reveal a complex pattern of motions in the RNA binding site for human U1A protein.25
179427412007A bipartite U1 site represses U1A expression by synergizing with PIE to inhibit nuclear polyadenylation.15
243620202014U1A regulates 3' processing of the survival motor neuron mRNA.11
214197782011Multistep kinetics of the U1A-SL2 RNA complex dissociation.5
213843382011U1A protein-stem loop 2 RNA recognition: prediction of structural differences from protein mutations.4
300398892018SNRPA enhances tumour cell growth in gastric cancer through modulating NGF expression.4
212984552011The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus.3
289548862017Small Nuclear Ribonucleoprotein Polypeptide A-Mediated Alternative Polyadenylation of STAT5B during Th1 Cell Differentiation.2
311071492019Nuclear retention element recruits U1 snRNP components to restrain spliced lncRNAs in the nucleus.2

Citation

Dessen P

SNRPA (small nuclear ribonucleoprotein polypeptide A)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56352/snrpa