Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SNTA1 (syntrophin alpha 1)

Identity

Alias (NCBI)LQT12
SNT1
TACIP1
dJ1187J4.5
HGNC (Hugo) SNTA1
HGNC Alias symbTACIP1
LQT12
HGNC Alias namepro-TGF-alpha cytoplasmic domain-interacting protein 1
 dystrophin-associated protein A1, 59kDa, acidic component
HGNC Previous nameSNT1
HGNC Previous namesyntrophin, alpha 1 (dystrophin-associated protein A1, 59kD, acidic component)
LocusID (NCBI) 6640
Atlas_Id 52306
Location 20q11.21  [Link to chromosome band 20q11]
Location_base_pair Starts at 33407957 and ends at 33443763 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARVCF (22q11.21) / SNTA1 (20q11.21)ZDHHC20 (13q12.11) / SNTA1 (20q11.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)SNTA1   11167
LRG (Locus Reference Genomic)LRG_332
Cards
Entrez_Gene (NCBI)SNTA1    syntrophin alpha 1
AliasesLQT12; SNT1; TACIP1; dJ1187J4.5
GeneCards (Weizmann)SNTA1
Ensembl hg19 (Hinxton)ENSG00000101400 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101400 [Gene_View]  ENSG00000101400 [Sequence]  chr20:33407957-33443763 [Contig_View]  SNTA1 [Vega]
ICGC DataPortalENSG00000101400
TCGA cBioPortalSNTA1
AceView (NCBI)SNTA1
Genatlas (Paris)SNTA1
SOURCE (Princeton)SNTA1
Genetics Home Reference (NIH)SNTA1
Genomic and cartography
GoldenPath hg38 (UCSC)SNTA1  -     chr20:33407957-33443763 -  20q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SNTA1  -     20q11.21   [Description]    (hg19-Feb_2009)
GoldenPathSNTA1 - 20q11.21 [CytoView hg19]  SNTA1 - 20q11.21 [CytoView hg38]
ImmunoBaseENSG00000101400
Genome Data Viewer NCBISNTA1 [Mapview hg19]  
OMIM601017   612955   
Gene and transcription
Genbank (Entrez)AK095942 AK291994 AK301800 AU118614 BC026215
RefSeq transcript (Entrez)NM_003098
Consensus coding sequences : CCDS (NCBI)SNTA1
Gene ExpressionSNTA1 [ NCBI-GEO ]   SNTA1 [ EBI - ARRAY_EXPRESS ]   SNTA1 [ SEEK ]   SNTA1 [ MEM ]
Gene Expression Viewer (FireBrowse)SNTA1 [ Firebrowse - Broad ]
GenevisibleExpression of SNTA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6640
GTEX Portal (Tissue expression)SNTA1
Human Protein AtlasENSG00000101400-SNTA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13424   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13424  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13424
PhosPhoSitePlusQ13424
Domaine pattern : Prosite (Expaxy)PDZ (PS50106)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)PDZ    PDZ_sf    PH-like_dom_sf    PH_domain    PHsplit_syntrophin    SNTA1    Syntrophin   
Domain families : Pfam (Sanger)PDZ (PF00595)    PH (PF00169)    PH_17 (PF18012)   
Domain families : Pfam (NCBI)pfam00595    pfam00169    pfam18012   
Domain families : Smart (EMBL)PDZ (SM00228)  PH (SM00233)  
Conserved Domain (NCBI)SNTA1
SuperfamilyQ13424
AlphaFold pdb e-kbQ13424   
Human Protein Atlas [tissue]ENSG00000101400-SNTA1 [tissue]
HPRD03009
Protein Interaction databases
DIP (DOE-UCLA)Q13424
IntAct (EBI)Q13424
BioGRIDSNTA1
STRING (EMBL)SNTA1
ZODIACSNTA1
Ontologies - Pathways
QuickGOQ13424
Ontology : AmiGOregulation of heart rate  regulation of vasoconstriction by circulating norepinephrine  actin binding  structural molecule activity  protein binding  calmodulin binding  intracellular anatomical structure  cytoplasm  cytoskeleton  muscle contraction  neuromuscular junction development  dystrophin-associated glycoprotein complex  syntrophin complex  lateral plasma membrane  sodium channel regulator activity  PDZ domain binding  neuromuscular junction  protein-containing complex  sarcolemma  ion channel binding  synapse  postsynaptic membrane  nitric-oxide synthase binding  ATPase binding  regulation of ventricular cardiac muscle cell membrane repolarization  ventricular cardiac muscle cell action potential  negative regulation of peptidyl-cysteine S-nitrosylation  regulation of sodium ion transmembrane transport  
Ontology : EGO-EBIregulation of heart rate  regulation of vasoconstriction by circulating norepinephrine  actin binding  structural molecule activity  protein binding  calmodulin binding  intracellular anatomical structure  cytoplasm  cytoskeleton  muscle contraction  neuromuscular junction development  dystrophin-associated glycoprotein complex  syntrophin complex  lateral plasma membrane  sodium channel regulator activity  PDZ domain binding  neuromuscular junction  protein-containing complex  sarcolemma  ion channel binding  synapse  postsynaptic membrane  nitric-oxide synthase binding  ATPase binding  regulation of ventricular cardiac muscle cell membrane repolarization  ventricular cardiac muscle cell action potential  negative regulation of peptidyl-cysteine S-nitrosylation  regulation of sodium ion transmembrane transport  
NDEx NetworkSNTA1
Atlas of Cancer Signalling NetworkSNTA1
Wikipedia pathwaysSNTA1
Orthology - Evolution
OrthoDB6640
GeneTree (enSembl)ENSG00000101400
Phylogenetic Trees/Animal Genes : TreeFamSNTA1
Homologs : HomoloGeneSNTA1
Homology/Alignments : Family Browser (UCSC)SNTA1
Gene fusions - Rearrangements
Fusion : QuiverSNTA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSNTA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SNTA1
dbVarSNTA1
ClinVarSNTA1
MonarchSNTA1
1000_GenomesSNTA1 
Exome Variant ServerSNTA1
GNOMAD BrowserENSG00000101400
Varsome BrowserSNTA1
ACMGSNTA1 variants
VarityQ13424
Genomic Variants (DGV)SNTA1 [DGVbeta]
DECIPHERSNTA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSNTA1 
Mutations
ICGC Data PortalSNTA1 
TCGA Data PortalSNTA1 
Broad Tumor PortalSNTA1
OASIS PortalSNTA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSNTA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSNTA1
Mutations and Diseases : HGMDSNTA1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSNTA1
DgiDB (Drug Gene Interaction Database)SNTA1
DoCM (Curated mutations)SNTA1
CIViC (Clinical Interpretations of Variants in Cancer)SNTA1
Cancer3DSNTA1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601017    612955   
Orphanet14727   
DisGeNETSNTA1
MedgenSNTA1
Genetic Testing Registry SNTA1
NextProtQ13424 [Medical]
GENETestsSNTA1
Target ValidationSNTA1
Huge Navigator SNTA1 [HugePedia]
ClinGenSNTA1
Clinical trials, drugs, therapy
MyCancerGenomeSNTA1
Protein Interactions : CTDSNTA1
Pharm GKB GenePA36007
PharosQ13424
Clinical trialSNTA1
Miscellaneous
canSAR (ICR)SNTA1
HarmonizomeSNTA1
DataMed IndexSNTA1
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSNTA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:31 CEST 2021
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