SNX1 (sorting nexin 1)

2007-12-01  

Identity

HGNC
LOCATION
15q22.31
LOCUSID
ALIAS
HsT17379,VPS5
FUSION GENES

Other Information

Locus ID:

NCBI: 6642
MIM: 601272
HGNC: 11172
Ensembl: ENSG00000028528

Variants:

dbSNP: 6642
ClinVar: 6642
TCGA: ENSG00000028528
COSMIC: SNX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000028528ENST00000261889Q13596
ENSG00000028528ENST00000380285J3KPH4
ENSG00000028528ENST00000558040H0YK58
ENSG00000028528ENST00000559061H0YK43
ENSG00000028528ENST00000559389H0YKL5
ENSG00000028528ENST00000559844Q13596
ENSG00000028528ENST00000560260H0YKD5
ENSG00000028528ENST00000560829H0YK42
ENSG00000028528ENST00000560861H0YKT3
ENSG00000028528ENST00000561026Q13596
ENSG00000028528ENST00000625244H0YKD5

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
154984862004Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides.168
171017782007Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.81
175024862007EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin.72
226731152012Identification of Alzheimer disease-associated variants in genes that regulate retromer function.63
164074032006An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins.62
121981322002The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation.61
180883232008SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors.60
219730562012SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation.54
214273582011MicroRNA-95 promotes cell proliferation and targets sorting Nexin 1 in human colorectal carcinoma.52
120580632002Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1.33

Citation

Dessen P

SNX1 (sorting nexin 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49891/snx1