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SNX14 (sorting nexin 14)

Identity

Alias_symbol (synonym)RGS-PX2
Other aliasSCAR20
HGNC (Hugo) SNX14
LocusID (NCBI) 57231
Atlas_Id 74048
Location 6q14.3  [Link to chromosome band 6q14]
Location_base_pair Starts at 85505497 and ends at 85594156 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GALM (2p22.1) / SNX14 (6q14.3)GRINA (8q24.3) / SNX14 (6q14.3)SNX14 (6q14.3) / NKAIN2 (6q22.31)
SNX14 (6q14.3) / PPP2R2A (8p21.2)SNX14 (6q14.3) / SYNCRIP (6q14.3)SNX14 NKAIN2
SNX14 SYNCRIP

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;6)(q14;q14) SNHG5/SNX14
t(6;6)(q14;q14) SNHG5/SNX14


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q14;q14) SNX14/SYNCRIP


External links

Nomenclature
HGNC (Hugo)SNX14   14977
Cards
Entrez_Gene (NCBI)SNX14  57231  sorting nexin 14
AliasesRGS-PX2; SCAR20
GeneCards (Weizmann)SNX14
Ensembl hg19 (Hinxton)ENSG00000135317 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135317 [Gene_View]  ENSG00000135317 [Sequence]  chr6:85505497-85594156 [Contig_View]  SNX14 [Vega]
ICGC DataPortalENSG00000135317
TCGA cBioPortalSNX14
AceView (NCBI)SNX14
Genatlas (Paris)SNX14
WikiGenes57231
SOURCE (Princeton)SNX14
Genetics Home Reference (NIH)SNX14
Genomic and cartography
GoldenPath hg38 (UCSC)SNX14  -     chr6:85505497-85594156 -  6q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SNX14  -     6q14.3   [Description]    (hg19-Feb_2009)
EnsemblSNX14 - 6q14.3 [CytoView hg19]  SNX14 - 6q14.3 [CytoView hg38]
Mapping of homologs : NCBISNX14 [Mapview hg19]  SNX14 [Mapview hg38]
OMIM616105   616354   
Gene and transcription
Genbank (Entrez)AF121863 AJ420561 AK000362 AK026479 AK095380
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SNX14
Cluster EST : UnigeneHs.485871 [ NCBI ]
CGAP (NCI)Hs.485871
Alternative Splicing GalleryENSG00000135317
Gene ExpressionSNX14 [ NCBI-GEO ]   SNX14 [ EBI - ARRAY_EXPRESS ]   SNX14 [ SEEK ]   SNX14 [ MEM ]
Gene Expression Viewer (FireBrowse)SNX14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57231
GTEX Portal (Tissue expression)SNX14
Human Protein AtlasENSG00000135317-SNX14 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5W7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5W7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5W7
Splice isoforms : SwissVarQ9Y5W7
PhosPhoSitePlusQ9Y5W7
Domaine pattern : Prosite (Expaxy)PX (PS50195)    PXA (PS51207)    RGS (PS50132)   
Domains : Interpro (EBI)Phox    Phox_assoc    RGS    Sorting_nexin_C   
Domain families : Pfam (Sanger)Nexin_C (PF08628)    PX (PF00787)    PXA (PF02194)    RGS (PF00615)   
Domain families : Pfam (NCBI)pfam08628    pfam00787    pfam02194    pfam00615   
Domain families : Smart (EMBL)PX (SM00312)  PXA (SM00313)  RGS (SM00315)  
Conserved Domain (NCBI)SNX14
DMDM Disease mutations57231
Blocks (Seattle)SNX14
PDB (SRS)4BGJ    4PQO    4PQP   
PDB (PDBSum)4BGJ    4PQO    4PQP   
PDB (IMB)4BGJ    4PQO    4PQP   
PDB (RSDB)4BGJ    4PQO    4PQP   
Structural Biology KnowledgeBase4BGJ    4PQO    4PQP   
SCOP (Structural Classification of Proteins)4BGJ    4PQO    4PQP   
CATH (Classification of proteins structures)4BGJ    4PQO    4PQP   
SuperfamilyQ9Y5W7
Human Protein Atlas [tissue]ENSG00000135317-SNX14 [tissue]
Peptide AtlasQ9Y5W7
HPRD11590
IPIIPI00419678   IPI00216696   IPI00940044   IPI00939803   IPI00553234   IPI00964479   IPI00965161   IPI00966327   IPI00965654   IPI00966501   IPI00965980   IPI00965345   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5W7
IntAct (EBI)Q9Y5W7
FunCoupENSG00000135317
BioGRIDSNX14
STRING (EMBL)SNX14
ZODIACSNX14
Ontologies - Pathways
QuickGOQ9Y5W7
Ontology : AmiGOlysosome  lysosomal membrane  late endosome  protein transport  integral component of membrane  dendrite  late endosome membrane  phosphatidylinositol-3,5-bisphosphate binding  autophagosome maturation  
Ontology : EGO-EBIlysosome  lysosomal membrane  late endosome  protein transport  integral component of membrane  dendrite  late endosome membrane  phosphatidylinositol-3,5-bisphosphate binding  autophagosome maturation  
NDEx NetworkSNX14
Atlas of Cancer Signalling NetworkSNX14
Wikipedia pathwaysSNX14
Orthology - Evolution
OrthoDB57231
GeneTree (enSembl)ENSG00000135317
Phylogenetic Trees/Animal Genes : TreeFamSNX14
HOVERGENQ9Y5W7
HOGENOMQ9Y5W7
Homologs : HomoloGeneSNX14
Homology/Alignments : Family Browser (UCSC)SNX14
Gene fusions - Rearrangements
Fusion PortalSNX14 NKAIN2
Fusion PortalSNX14 SYNCRIP
Fusion : QuiverSNX14
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSNX14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SNX14
dbVarSNX14
ClinVarSNX14
1000_GenomesSNX14 
Exome Variant ServerSNX14
ExAC (Exome Aggregation Consortium)ENSG00000135317
GNOMAD BrowserENSG00000135317
Varsome BrowserSNX14
Genetic variants : HAPMAP57231
Genomic Variants (DGV)SNX14 [DGVbeta]
DECIPHERSNX14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSNX14 
Mutations
ICGC Data PortalSNX14 
TCGA Data PortalSNX14 
Broad Tumor PortalSNX14
OASIS PortalSNX14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSNX14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSNX14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SNX14
DgiDB (Drug Gene Interaction Database)SNX14
DoCM (Curated mutations)SNX14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SNX14 (select a term)
intoGenSNX14
Cancer3DSNX14(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616105    616354   
Orphanet22694   
DisGeNETSNX14
MedgenSNX14
Genetic Testing Registry SNX14
NextProtQ9Y5W7 [Medical]
TSGene57231
GENETestsSNX14
Target ValidationSNX14
Huge Navigator SNX14 [HugePedia]
snp3D : Map Gene to Disease57231
BioCentury BCIQSNX14
ClinGenSNX14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57231
Chemical/Pharm GKB GenePA129840867
Clinical trialSNX14
Miscellaneous
canSAR (ICR)SNX14 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSNX14
EVEXSNX14
GoPubMedSNX14
iHOPSNX14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 14:32:29 CEST 2018

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