SNX18 (sorting nexin 18)

2014-11-01  

Identity

HGNC
SNX18
LOCATION
5q11.2
LOCUSID
112574
ALIAS
SH3PX2,SH3PXD3B,SNAG1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 112574
HGNC: 19245
Ensembl: ENSG00000178996

Variants:

dbSNP: 112574
ClinVar: 112574
TCGA: ENSG00000178996
COSMIC: SNX18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178996ENST00000326277Q96RF0
ENSG00000178996ENST00000343017Q96RF0
ENSG00000178996ENST00000381410Q96RF0

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
238782782013Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation.59
184112442008SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1-positive endosomal trafficking.36
204273132010SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane.33
219694672011Interaction between FIP5 and SNX18 regulates epithelial lumen formation.22
227183502012SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis.17
294376952018SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2.13

Citation

Dessen P

SNX18 (sorting nexin 18)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74052/snx18