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SNX2 (sorting nexin 2)

Identity

Alias (NCBI)TRG-9
HGNC (Hugo) SNX2
LocusID (NCBI) 6643
Atlas_Id 53051
Location 5q23.2  [Link to chromosome band 5q23]
Location_base_pair Starts at 122775080 and ends at 122834541 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SNHG1 (11q12.3) / SNX2 (5q23.2)SNX2 (5q23.2) / ABL1 (9q34.12)SNX2 (5q23.2) / B4GALT5 (20q13.13)
SNX2 (5q23.2) / ZFC3H1 (12q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;9)(q23;q34) SNX2/ABL1


External links

 

Nomenclature
HGNC (Hugo)SNX2   11173
Cards
Entrez_Gene (NCBI)SNX2    sorting nexin 2
AliasesTRG-9
GeneCards (Weizmann)SNX2
Ensembl hg19 (Hinxton)ENSG00000205302 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000205302 [Gene_View]  ENSG00000205302 [Sequence]  chr5:122775080-122834541 [Contig_View]  SNX2 [Vega]
ICGC DataPortalENSG00000205302
TCGA cBioPortalSNX2
AceView (NCBI)SNX2
Genatlas (Paris)SNX2
SOURCE (Princeton)SNX2
Genetics Home Reference (NIH)SNX2
Genomic and cartography
GoldenPath hg38 (UCSC)SNX2  -     chr5:122775080-122834541 +  5q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SNX2  -     5q23.2   [Description]    (hg19-Feb_2009)
GoldenPathSNX2 - 5q23.2 [CytoView hg19]  SNX2 - 5q23.2 [CytoView hg38]
ImmunoBaseENSG00000205302
Genome Data Viewer NCBISNX2 [Mapview hg19]  
OMIM605929   
Gene and transcription
Genbank (Entrez)AF043453 AF065482 AK002170 AK023581 AK023716
RefSeq transcript (Entrez)NM_001278199 NM_003100
Consensus coding sequences : CCDS (NCBI)SNX2
Gene ExpressionSNX2 [ NCBI-GEO ]   SNX2 [ EBI - ARRAY_EXPRESS ]   SNX2 [ SEEK ]   SNX2 [ MEM ]
Gene Expression Viewer (FireBrowse)SNX2 [ Firebrowse - Broad ]
GenevisibleExpression of SNX2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6643
GTEX Portal (Tissue expression)SNX2
Human Protein AtlasENSG00000205302-SNX2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60749   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60749  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60749
PhosPhoSitePlusO60749
Domaine pattern : Prosite (Expaxy)PX (PS50195)   
Domains : Interpro (EBI)AH/BAR_dom_sf    PX_dom    PX_dom_sf    SNX2    SNX2_PX    Sorting_nexin_N    Vps5_C   
Domain families : Pfam (Sanger)PX (PF00787)    Sorting_nexin (PF03700)    Vps5 (PF09325)   
Domain families : Pfam (NCBI)pfam00787    pfam03700    pfam09325   
Domain families : Smart (EMBL)PX (SM00312)  
Conserved Domain (NCBI)SNX2
SuperfamilyO60749
AlphaFold pdb e-kbO60749   
Human Protein Atlas [tissue]ENSG00000205302-SNX2 [tissue]
HPRD09332
Protein Interaction databases
DIP (DOE-UCLA)O60749
IntAct (EBI)O60749
BioGRIDSNX2
STRING (EMBL)SNX2
ZODIACSNX2
Ontologies - Pathways
QuickGOO60749
Ontology : AmiGOepidermal growth factor receptor binding  insulin receptor binding  protein binding  cytoplasm  lysosome  endosome  endosome  cytosol  intracellular protein transport  endocytosis  endosome membrane  endosome membrane  membrane  lamellipodium  retromer complex  retromer, tubulation complex  retromer, tubulation complex  early endosome membrane  protein-containing complex  early endosome to Golgi transport  phosphatidylinositol binding  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  identical protein binding  protein homodimerization activity  cadherin binding  protein heterodimerization activity  lamellipodium morphogenesis  transferrin receptor binding  leptin receptor binding  
Ontology : EGO-EBIepidermal growth factor receptor binding  insulin receptor binding  protein binding  cytoplasm  lysosome  endosome  endosome  cytosol  intracellular protein transport  endocytosis  endosome membrane  endosome membrane  membrane  lamellipodium  retromer complex  retromer, tubulation complex  retromer, tubulation complex  early endosome membrane  protein-containing complex  early endosome to Golgi transport  phosphatidylinositol binding  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  identical protein binding  protein homodimerization activity  cadherin binding  protein heterodimerization activity  lamellipodium morphogenesis  transferrin receptor binding  leptin receptor binding  
NDEx NetworkSNX2
Atlas of Cancer Signalling NetworkSNX2
Wikipedia pathwaysSNX2
Orthology - Evolution
OrthoDB6643
GeneTree (enSembl)ENSG00000205302
Phylogenetic Trees/Animal Genes : TreeFamSNX2
Homologs : HomoloGeneSNX2
Homology/Alignments : Family Browser (UCSC)SNX2
Gene fusions - Rearrangements
Fusion : MitelmanSNX2/ABL1 [5q23.2/9q34.12]  
Fusion : QuiverSNX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSNX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SNX2
dbVarSNX2
ClinVarSNX2
MonarchSNX2
1000_GenomesSNX2 
Exome Variant ServerSNX2
GNOMAD BrowserENSG00000205302
Varsome BrowserSNX2
ACMGSNX2 variants
VarityO60749
Genomic Variants (DGV)SNX2 [DGVbeta]
DECIPHERSNX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSNX2 
Mutations
ICGC Data PortalSNX2 
TCGA Data PortalSNX2 
Broad Tumor PortalSNX2
OASIS PortalSNX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSNX2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSNX2
Mutations and Diseases : HGMDSNX2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSNX2
DgiDB (Drug Gene Interaction Database)SNX2
DoCM (Curated mutations)SNX2
CIViC (Clinical Interpretations of Variants in Cancer)SNX2
Cancer3DSNX2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605929   
Orphanet
DisGeNETSNX2
MedgenSNX2
Genetic Testing Registry SNX2
NextProtO60749 [Medical]
GENETestsSNX2
Target ValidationSNX2
Huge Navigator SNX2 [HugePedia]
ClinGenSNX2
Clinical trials, drugs, therapy
MyCancerGenomeSNX2
Protein Interactions : CTDSNX2
Pharm GKB GenePA36012
PharosO60749
Clinical trialSNX2
Miscellaneous
canSAR (ICR)SNX2
HarmonizomeSNX2
DataMed IndexSNX2
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSNX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:32 CEST 2021

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