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SNX2 (sorting nexin 2)

Identity

Other aliasTRG-9
HGNC (Hugo) SNX2
LocusID (NCBI) 6643
Atlas_Id 53051
Location 5q23.2  [Link to chromosome band 5q23]
Location_base_pair Starts at 122110691 and ends at 122170234 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SNHG1 (11q12.3) / SNX2 (5q23.2)SNX2 (5q23.2) / ABL1 (9q34.12)SNX2 (5q23.2) / B4GALT5 (20q13.13)
SNX2 (5q23.2) / ZFC3H1 (12q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SNX2   11173
Cards
Entrez_Gene (NCBI)SNX2  6643  sorting nexin 2
AliasesTRG-9
GeneCards (Weizmann)SNX2
Ensembl hg19 (Hinxton)ENSG00000205302 [Gene_View]  chr5:122110691-122170234 [Contig_View]  SNX2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000205302 [Gene_View]  chr5:122110691-122170234 [Contig_View]  SNX2 [Vega]
ICGC DataPortalENSG00000205302
TCGA cBioPortalSNX2
AceView (NCBI)SNX2
Genatlas (Paris)SNX2
WikiGenes6643
SOURCE (Princeton)SNX2
Genetics Home Reference (NIH)SNX2
Genomic and cartography
GoldenPath hg19 (UCSC)SNX2  -     chr5:122110691-122170234 +  5q23.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SNX2  -     5q23.2   [Description]    (hg38-Dec_2013)
EnsemblSNX2 - 5q23.2 [CytoView hg19]  SNX2 - 5q23.2 [CytoView hg38]
Mapping of homologs : NCBISNX2 [Mapview hg19]  SNX2 [Mapview hg38]
OMIM605929   
Gene and transcription
Genbank (Entrez)AF043453 AF065482 AK002170 AK023581 AK023716
RefSeq transcript (Entrez)NM_001278199 NM_003100
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_034772 NW_004929323
Consensus coding sequences : CCDS (NCBI)SNX2
Cluster EST : UnigeneHs.713554 [ NCBI ]
CGAP (NCI)Hs.713554
Alternative Splicing GalleryENSG00000205302
Gene ExpressionSNX2 [ NCBI-GEO ]   SNX2 [ EBI - ARRAY_EXPRESS ]   SNX2 [ SEEK ]   SNX2 [ MEM ]
Gene Expression Viewer (FireBrowse)SNX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6643
GTEX Portal (Tissue expression)SNX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60749   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60749  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60749
Splice isoforms : SwissVarO60749
PhosPhoSitePlusO60749
Domaine pattern : Prosite (Expaxy)PX (PS50195)   
Domains : Interpro (EBI)Phox    SNX2    Sorting_nexin_N    Vps5_C   
Domain families : Pfam (Sanger)PX (PF00787)    Sorting_nexin (PF03700)    Vps5 (PF09325)   
Domain families : Pfam (NCBI)pfam00787    pfam03700    pfam09325   
Domain families : Smart (EMBL)PX (SM00312)  
Conserved Domain (NCBI)SNX2
DMDM Disease mutations6643
Blocks (Seattle)SNX2
SuperfamilyO60749
Human Protein AtlasENSG00000205302
Peptide AtlasO60749
HPRD09332
IPIIPI00299095   IPI00964716   IPI00967160   IPI00966296   
Protein Interaction databases
DIP (DOE-UCLA)O60749
IntAct (EBI)O60749
FunCoupENSG00000205302
BioGRIDSNX2
STRING (EMBL)SNX2
ZODIACSNX2
Ontologies - Pathways
QuickGOO60749
Ontology : AmiGOepidermal growth factor receptor binding  insulin receptor binding  protein binding  cytoplasm  cytosol  cytosol  cytosol  intracellular protein transport  endocytosis  endosome membrane  membrane  vesicle organization  extrinsic component of membrane  lamellipodium  retromer complex  retromer, tubulation complex  retromer, tubulation complex  early endosome membrane  early endosome to Golgi transport  phosphatidylinositol binding  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  protein homodimerization activity  protein complex  protein heterodimerization activity  protein heterodimerization activity  protein oligomerization  extracellular exosome  lamellipodium morphogenesis  transferrin receptor binding  leptin receptor binding  
Ontology : EGO-EBIepidermal growth factor receptor binding  insulin receptor binding  protein binding  cytoplasm  cytosol  cytosol  cytosol  intracellular protein transport  endocytosis  endosome membrane  membrane  vesicle organization  extrinsic component of membrane  lamellipodium  retromer complex  retromer, tubulation complex  retromer, tubulation complex  early endosome membrane  early endosome to Golgi transport  phosphatidylinositol binding  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  protein homodimerization activity  protein complex  protein heterodimerization activity  protein heterodimerization activity  protein oligomerization  extracellular exosome  lamellipodium morphogenesis  transferrin receptor binding  leptin receptor binding  
NDEx NetworkSNX2
Atlas of Cancer Signalling NetworkSNX2
Wikipedia pathwaysSNX2
Orthology - Evolution
OrthoDB6643
GeneTree (enSembl)ENSG00000205302
Phylogenetic Trees/Animal Genes : TreeFamSNX2
HOVERGENO60749
HOGENOMO60749
Homologs : HomoloGeneSNX2
Homology/Alignments : Family Browser (UCSC)SNX2
Gene fusions - Rearrangements
Fusion : MitelmanSNX2/ABL1 [5q23.2/9q34.12]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSNX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SNX2
dbVarSNX2
ClinVarSNX2
1000_GenomesSNX2 
Exome Variant ServerSNX2
ExAC (Exome Aggregation Consortium)SNX2 (select the gene name)
Genetic variants : HAPMAP6643
Genomic Variants (DGV)SNX2 [DGVbeta]
DECIPHER (Syndromes)5:122110691-122170234  ENSG00000205302
CONAN: Copy Number AnalysisSNX2 
Mutations
ICGC Data PortalSNX2 
TCGA Data PortalSNX2 
Broad Tumor PortalSNX2
OASIS PortalSNX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSNX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSNX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SNX2
DgiDB (Drug Gene Interaction Database)SNX2
DoCM (Curated mutations)SNX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SNX2 (select a term)
intoGenSNX2
Cancer3DSNX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605929   
Orphanet
MedgenSNX2
Genetic Testing Registry SNX2
NextProtO60749 [Medical]
TSGene6643
GENETestsSNX2
Huge Navigator SNX2 [HugePedia]
snp3D : Map Gene to Disease6643
BioCentury BCIQSNX2
ClinGenSNX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6643
Chemical/Pharm GKB GenePA36012
Clinical trialSNX2
Miscellaneous
canSAR (ICR)SNX2 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSNX2
EVEXSNX2
GoPubMedSNX2
iHOPSNX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:20:21 CEST 2017

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