SNX2 (sorting nexin 2)

2012-11-01  

Identity

HGNC
LOCATION
5q23.2
LOCUSID
ALIAS
TRG-9
FUSION GENES

Other Information

Locus ID:

NCBI: 6643
MIM: 605929
HGNC: 11173
Ensembl: ENSG00000205302

Variants:

dbSNP: 6643
ClinVar: 6643
TCGA: ENSG00000205302
COSMIC: SNX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205302ENST00000379516O60749
ENSG00000205302ENST00000505934D6RC15
ENSG00000205302ENST00000512394D6RBT1
ENSG00000205302ENST00000514949O60749

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
388363262024Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cells.0
388363262024Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cells.0
348177772022Human sorting nexin 2 protein interacts with Influenza A virus PA protein and has a negative regulatory effect on the virus replication.1
348177772022Human sorting nexin 2 protein interacts with Influenza A virus PA protein and has a negative regulatory effect on the virus replication.1
329943212020Host Retromer Protein Sorting Nexin 2 Interacts with Human Respiratory Syncytial Virus Structural Proteins and is Required for Efficient Viral Production.9
329943212020Host Retromer Protein Sorting Nexin 2 Interacts with Human Respiratory Syncytial Virus Structural Proteins and is Required for Efficient Viral Production.9
235318552014Sorting Nexin 2 (SNX2): a potential marker of active thyrocytes in normal and hyperfunctioning thyroid disorders.1
235318552014Sorting Nexin 2 (SNX2): a potential marker of active thyrocytes in normal and hyperfunctioning thyroid disorders.1
233604892013Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs.13
233604892013Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs.13
206049012010A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling.10
206049012010A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling.10
171017782007Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.112
173198032007Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins.22
171017782007Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.112

Citation

Dessen P

SNX2 (sorting nexin 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53051/snx2