SNX33 (sorting nexin 33)

2014-11-01  

Identity

HGNC
SNX33
LOCATION
15q24.2
LOCUSID
257364
ALIAS
SH3PX3,SH3PXD3C,SNX30
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 257364
HGNC: 28468
Ensembl: ENSG00000173548

Variants:

dbSNP: 257364
ClinVar: 257364
TCGA: ENSG00000173548
COSMIC: SNX33

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173548ENST00000308527Q8WV41
ENSG00000173548ENST00000569152H3BPR3

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
183537732008A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.39
227183502012SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis.17
194876892009Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein.15
197186582009Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins.9
209646292011Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33.9
184197542008The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding.8

Citation

Dessen P

SNX33 (sorting nexin 33)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74062/snx33