SNX5 (sorting nexin 5)

2013-05-01  

Identity

HGNC
LOCATION
20p11.23
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 27131
MIM: 605937
HGNC: 14969
Ensembl: ENSG00000089006

Variants:

dbSNP: 27131
ClinVar: 27131
TCGA: ENSG00000089006
COSMIC: SNX5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089006ENST00000377759Q9Y5X3
ENSG00000089006ENST00000377768Q9Y5X3
ENSG00000089006ENST00000419004Q5QPE4
ENSG00000089006ENST00000431277Q5QPE5
ENSG00000089006ENST00000463050A0A087WUY5
ENSG00000089006ENST00000481323U3KQL0
ENSG00000089006ENST00000486039U3KQL0
ENSG00000089006ENST00000606557Q9Y5X3
ENSG00000089006ENST00000606557A0A0S2Z5F1
ENSG00000089006ENST00000606602U3KQP5

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
171485742007A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer.88
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.63
155617692004Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation.25
282262392017Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis.18
231950372013Novel role of sorting nexin 5 in renal D(1) dopamine receptor trafficking and function: implications for hypertension.15
185962352008The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport.12
224868132012Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-2.5
258258162015Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells.5
315760582019Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins.4
294449452018Interaction of Human Cytomegalovirus Tegument Proteins ppUL35 and ppUL35A with Sorting Nexin 5 Regulates Glycoprotein B (gpUL55) Localization.3

Citation

Dessen P

SNX5 (sorting nexin 5)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53258/snx5