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SNX6 (sorting nexin 6)

Identity

Alias (NCBI)MSTP010
TFAF2
HGNC (Hugo) SNX6
LocusID (NCBI) 58533
Atlas_Id 42349
Location 14q13.1  [Link to chromosome band 14q13]
Location_base_pair Starts at 34561093 and ends at 34630148 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AD_1 () / SNX6 (14q13.1)EAPP (14q13.1) / SNX6 (14q13.1)PCMTD2 (20q13.33) / SNX6 (14q13.1)
SNX6 (14q13.1) / MIPOL1 (14q13.3)SNX6 (14q13.1) / TCF3 (19p13.3)SNX6 (14q13.1) / ZC3H13 (13q14.13)
cytochrome_b () / SNX6 (14q13.1)EAPP 14q13.1 / SNX6 14q13.1PCMTD2 20q13.33 / SNX6 14q13.1
SNX6 14q13.1 / MIPOL1 14q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SNX6   14970
Cards
Entrez_Gene (NCBI)SNX6    sorting nexin 6
AliasesMSTP010; TFAF2
GeneCards (Weizmann)SNX6
Ensembl hg19 (Hinxton)ENSG00000129515 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129515 [Gene_View]  ENSG00000129515 [Sequence]  chr14:34561093-34630148 [Contig_View]  SNX6 [Vega]
ICGC DataPortalENSG00000129515
TCGA cBioPortalSNX6
AceView (NCBI)SNX6
Genatlas (Paris)SNX6
SOURCE (Princeton)SNX6
Genetics Home Reference (NIH)SNX6
Genomic and cartography
GoldenPath hg38 (UCSC)SNX6  -     chr14:34561093-34630148 -  14q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SNX6  -     14q13.1   [Description]    (hg19-Feb_2009)
GoldenPathSNX6 - 14q13.1 [CytoView hg19]  SNX6 - 14q13.1 [CytoView hg38]
ImmunoBaseENSG00000129515
Genome Data Viewer NCBISNX6 [Mapview hg19]  
OMIM606098   
Gene and transcription
Genbank (Entrez)AF109364 AF121856 AI446034 AK021456 AK124315
RefSeq transcript (Entrez)NM_001366519 NM_021249 NM_152233
Consensus coding sequences : CCDS (NCBI)SNX6
Gene ExpressionSNX6 [ NCBI-GEO ]   SNX6 [ EBI - ARRAY_EXPRESS ]   SNX6 [ SEEK ]   SNX6 [ MEM ]
Gene Expression Viewer (FireBrowse)SNX6 [ Firebrowse - Broad ]
GenevisibleExpression of SNX6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)58533
GTEX Portal (Tissue expression)SNX6
Human Protein AtlasENSG00000129515-SNX6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNH7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNH7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNH7
PhosPhoSitePlusQ9UNH7
Domaine pattern : Prosite (Expaxy)PX (PS50195)   
Domains : Interpro (EBI)AH/BAR_dom_sf    PX_dom    PX_dom_sf    PX_SNX6    SNX5/SNX6/SNX32    SNX6    Vps5_C   
Domain families : Pfam (Sanger)PX (PF00787)    Vps5 (PF09325)   
Domain families : Pfam (NCBI)pfam00787    pfam09325   
Conserved Domain (NCBI)SNX6
SuperfamilyQ9UNH7
AlphaFold pdb e-kbQ9UNH7   
Human Protein Atlas [tissue]ENSG00000129515-SNX6 [tissue]
HPRD12086
Protein Interaction databases
DIP (DOE-UCLA)Q9UNH7
IntAct (EBI)Q9UNH7
BioGRIDSNX6
STRING (EMBL)SNX6
ZODIACSNX6
Ontologies - Pathways
QuickGOQ9UNH7
Ontology : AmiGOprotein binding  nucleus  cytoplasm  endosome  cytosol  intracellular protein transport  intracellular protein transport  negative regulation of epidermal growth factor-activated receptor activity  regulation of macroautophagy  negative regulation of transforming growth factor beta receptor signaling pathway  retromer complex  retromer, tubulation complex  early endosome membrane  dynactin binding  dynactin binding  type I transforming growth factor beta receptor binding  phosphatidylinositol binding  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  protein homodimerization activity  negative regulation of neuron apoptotic process  negative regulation of transcription, DNA-templated  cellular response to epidermal growth factor stimulus  tubular endosome  regulation of histamine secretion by mast cell  cellular response to amyloid-beta  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  endosome  cytosol  intracellular protein transport  intracellular protein transport  negative regulation of epidermal growth factor-activated receptor activity  regulation of macroautophagy  negative regulation of transforming growth factor beta receptor signaling pathway  retromer complex  retromer, tubulation complex  early endosome membrane  dynactin binding  dynactin binding  type I transforming growth factor beta receptor binding  phosphatidylinositol binding  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  protein homodimerization activity  negative regulation of neuron apoptotic process  negative regulation of transcription, DNA-templated  cellular response to epidermal growth factor stimulus  tubular endosome  regulation of histamine secretion by mast cell  cellular response to amyloid-beta  
NDEx NetworkSNX6
Atlas of Cancer Signalling NetworkSNX6
Wikipedia pathwaysSNX6
Orthology - Evolution
OrthoDB58533
GeneTree (enSembl)ENSG00000129515
Phylogenetic Trees/Animal Genes : TreeFamSNX6
Homologs : HomoloGeneSNX6
Homology/Alignments : Family Browser (UCSC)SNX6
Gene fusions - Rearrangements
Fusion : MitelmanEAPP/SNX6 [14q13.1/14q13.1]  
Fusion : MitelmanPCMTD2/SNX6 [20q13.33/14q13.1]  
Fusion Cancer (Beijing)AD_1 [SNX6]  -  14q13.1 [FUSC003243]
Fusion Cancer (Beijing)cytochrome_b [SNX6]  -  14q13.1 [FUSC000479]
Fusion : QuiverSNX6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSNX6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SNX6
dbVarSNX6
ClinVarSNX6
MonarchSNX6
1000_GenomesSNX6 
Exome Variant ServerSNX6
GNOMAD BrowserENSG00000129515
Varsome BrowserSNX6
ACMGSNX6 variants
VarityQ9UNH7
Genomic Variants (DGV)SNX6 [DGVbeta]
DECIPHERSNX6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSNX6 
Mutations
ICGC Data PortalSNX6 
TCGA Data PortalSNX6 
Broad Tumor PortalSNX6
OASIS PortalSNX6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSNX6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSNX6
Mutations and Diseases : HGMDSNX6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSNX6
DgiDB (Drug Gene Interaction Database)SNX6
DoCM (Curated mutations)SNX6
CIViC (Clinical Interpretations of Variants in Cancer)SNX6
Cancer3DSNX6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606098   
Orphanet
DisGeNETSNX6
MedgenSNX6
Genetic Testing Registry SNX6
NextProtQ9UNH7 [Medical]
GENETestsSNX6
Target ValidationSNX6
Huge Navigator SNX6 [HugePedia]
ClinGenSNX6
Clinical trials, drugs, therapy
MyCancerGenomeSNX6
Protein Interactions : CTDSNX6
Pharm GKB GenePA37946
PharosQ9UNH7
Clinical trialSNX6
Miscellaneous
canSAR (ICR)SNX6
HarmonizomeSNX6
DataMed IndexSNX6
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSNX6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:34 CEST 2021

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