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SNX6 (sorting nexin 6)

Identity

Other aliasMSTP010
TFAF2
HGNC (Hugo) SNX6
LocusID (NCBI) 58533
Atlas_Id 42349
Location 14q13.1  [Link to chromosome band 14q13]
Location_base_pair Starts at 35030618 and ends at 35099315 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AD_1 () / SNX6 (14q13.1)EAPP (14q13.1) / SNX6 (14q13.1)PCMTD2 (20q13.33) / SNX6 (14q13.1)
SNX6 (14q13.1) / MIPOL1 (14q13.3)SNX6 (14q13.1) / TCF3 (19p13.3)SNX6 (14q13.1) / ZC3H13 (13q14.13)
cytochrome_b () / SNX6 (14q13.1)EAPP 14q13.1 / SNX6 14q13.1PCMTD2 20q13.33 / SNX6 14q13.1
SNX6 14q13.1 / MIPOL1 14q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SNX6   14970
Cards
Entrez_Gene (NCBI)SNX6  58533  sorting nexin 6
AliasesMSTP010; TFAF2
GeneCards (Weizmann)SNX6
Ensembl hg19 (Hinxton)ENSG00000129515 [Gene_View]  chr14:35030618-35099315 [Contig_View]  SNX6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000129515 [Gene_View]  chr14:35030618-35099315 [Contig_View]  SNX6 [Vega]
ICGC DataPortalENSG00000129515
TCGA cBioPortalSNX6
AceView (NCBI)SNX6
Genatlas (Paris)SNX6
WikiGenes58533
SOURCE (Princeton)SNX6
Genetics Home Reference (NIH)SNX6
Genomic and cartography
GoldenPath hg19 (UCSC)SNX6  -     chr14:35030618-35099315 -  14q13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SNX6  -     14q13.1   [Description]    (hg38-Dec_2013)
EnsemblSNX6 - 14q13.1 [CytoView hg19]  SNX6 - 14q13.1 [CytoView hg38]
Mapping of homologs : NCBISNX6 [Mapview hg19]  SNX6 [Mapview hg38]
OMIM606098   
Gene and transcription
Genbank (Entrez)AF109364 AF121856 AK021456 AK124315 AK292250
RefSeq transcript (Entrez)NM_021249 NM_152233
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)SNX6
Cluster EST : UnigeneHs.356647 [ NCBI ]
CGAP (NCI)Hs.356647
Alternative Splicing GalleryENSG00000129515
Gene ExpressionSNX6 [ NCBI-GEO ]   SNX6 [ EBI - ARRAY_EXPRESS ]   SNX6 [ SEEK ]   SNX6 [ MEM ]
Gene Expression Viewer (FireBrowse)SNX6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)58533
GTEX Portal (Tissue expression)SNX6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNH7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNH7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNH7
Splice isoforms : SwissVarQ9UNH7
PhosPhoSitePlusQ9UNH7
Domaine pattern : Prosite (Expaxy)PX (PS50195)   
Domains : Interpro (EBI)AH/BAR-dom    Phox    SNX5/SNX6/SNX32    SNX6    Vps5_C   
Domain families : Pfam (Sanger)PX (PF00787)    Vps5 (PF09325)   
Domain families : Pfam (NCBI)pfam00787    pfam09325   
Conserved Domain (NCBI)SNX6
DMDM Disease mutations58533
Blocks (Seattle)SNX6
SuperfamilyQ9UNH7
Human Protein AtlasENSG00000129515
Peptide AtlasQ9UNH7
HPRD12086
IPIIPI00910184   IPI01025966   IPI01026075   IPI01025269   IPI01025387   IPI01025591   IPI01025602   IPI00258833   IPI00298111   
Protein Interaction databases
DIP (DOE-UCLA)Q9UNH7
IntAct (EBI)Q9UNH7
FunCoupENSG00000129515
BioGRIDSNX6
STRING (EMBL)SNX6
ZODIACSNX6
Ontologies - Pathways
QuickGOQ9UNH7
Ontology : AmiGOprotein binding  intracellular  nucleus  cytoplasm  cytosol  cytosol  intracellular protein transport  intracellular protein transport  endocytosis  negative regulation of epidermal growth factor-activated receptor activity  cytoplasmic, membrane-bounded vesicle  vesicle organization  regulation of macroautophagy  extrinsic component of membrane  negative regulation of transforming growth factor beta receptor signaling pathway  retromer complex  retromer, tubulation complex  early endosome membrane  dynactin binding  phosphatidylinositol binding  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  protein homodimerization activity  negative regulation of transcription, DNA-templated  protein heterodimerization activity  tubular endosome  regulation of histamine secretion by mast cell  
Ontology : EGO-EBIprotein binding  intracellular  nucleus  cytoplasm  cytosol  cytosol  intracellular protein transport  intracellular protein transport  endocytosis  negative regulation of epidermal growth factor-activated receptor activity  cytoplasmic, membrane-bounded vesicle  vesicle organization  regulation of macroautophagy  extrinsic component of membrane  negative regulation of transforming growth factor beta receptor signaling pathway  retromer complex  retromer, tubulation complex  early endosome membrane  dynactin binding  phosphatidylinositol binding  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  protein homodimerization activity  negative regulation of transcription, DNA-templated  protein heterodimerization activity  tubular endosome  regulation of histamine secretion by mast cell  
NDEx NetworkSNX6
Atlas of Cancer Signalling NetworkSNX6
Wikipedia pathwaysSNX6
Orthology - Evolution
OrthoDB58533
GeneTree (enSembl)ENSG00000129515
Phylogenetic Trees/Animal Genes : TreeFamSNX6
HOVERGENQ9UNH7
HOGENOMQ9UNH7
Homologs : HomoloGeneSNX6
Homology/Alignments : Family Browser (UCSC)SNX6
Gene fusions - Rearrangements
Fusion : MitelmanEAPP/SNX6 [14q13.1/14q13.1]  [t(14;14)(q13;q13)]  
Fusion : MitelmanPCMTD2/SNX6 [20q13.33/14q13.1]  [t(14;20)(q13;q13)]  
Fusion: TCGAEAPP 14q13.1 SNX6 14q13.1 LUAD
Fusion: TCGAPCMTD2 20q13.33 SNX6 14q13.1 BRCA
Fusion: TCGASNX6 14q13.1 MIPOL1 14q13.3 LUAD
Fusion Cancer (Beijing)AD_1 [SNX6]  -  14q13.1 [FUSC003243]
Fusion Cancer (Beijing)cytochrome_b [SNX6]  -  14q13.1 [FUSC000479]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSNX6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SNX6
dbVarSNX6
ClinVarSNX6
1000_GenomesSNX6 
Exome Variant ServerSNX6
ExAC (Exome Aggregation Consortium)SNX6 (select the gene name)
Genetic variants : HAPMAP58533
Genomic Variants (DGV)SNX6 [DGVbeta]
DECIPHER (Syndromes)14:35030618-35099315  ENSG00000129515
CONAN: Copy Number AnalysisSNX6 
Mutations
ICGC Data PortalSNX6 
TCGA Data PortalSNX6 
Broad Tumor PortalSNX6
OASIS PortalSNX6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSNX6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSNX6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SNX6
DgiDB (Drug Gene Interaction Database)SNX6
DoCM (Curated mutations)SNX6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SNX6 (select a term)
intoGenSNX6
Cancer3DSNX6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606098   
Orphanet
MedgenSNX6
Genetic Testing Registry SNX6
NextProtQ9UNH7 [Medical]
TSGene58533
GENETestsSNX6
Huge Navigator SNX6 [HugePedia]
snp3D : Map Gene to Disease58533
BioCentury BCIQSNX6
ClinGenSNX6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD58533
Chemical/Pharm GKB GenePA37946
Clinical trialSNX6
Miscellaneous
canSAR (ICR)SNX6 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSNX6
EVEXSNX6
GoPubMedSNX6
iHOPSNX6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:20:23 CEST 2017

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