SNX9 (sorting nexin 9)

2014-08-01  

Identity

HGNC
SNX9
LOCATION
6q25.3
LOCUSID
51429
ALIAS
SDP1,SH3PX1,SH3PXD3A,WISP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51429
MIM: 605952
HGNC: 14973
Ensembl: ENSG00000130340

Variants:

dbSNP: 51429
ClinVar: 51429
TCGA: ENSG00000130340
COSMIC: SNX9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130340ENST00000392185Q9Y5X1
ENSG00000130340ENST00000614703A0A087WZW2
ENSG00000130340ENST00000614800A0A087WVE4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
176091092007SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis.85
157032092005SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.81
179480572007The PX-BAR membrane-remodeling unit of sorting nexin 9.67
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
129529492003Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components.59
183883132008SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2.43
189406122008Structure and plasticity of Endophilin and Sorting Nexin 9.35
172423502007Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells.34
152990202004Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9.33
117991182002The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation.28

Citation

Dessen P

SNX9 (sorting nexin 9)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54654/snx9