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SOAT1 (sterol O-acyltransferase 1)

Identity

Alias_namesSOAT
STAT
sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
Alias_symbol (synonym)ACAT
Other aliasACACT
ACAT-1
ACAT1
HGNC (Hugo) SOAT1
LocusID (NCBI) 6646
Atlas_Id 43926
Location 1q25.2  [Link to chromosome band 1q25]
Location_base_pair Starts at 179293714 and ends at 179358679 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MSRA (8p23.1) / SOAT1 (1q25.2)SOAT1 (1q25.2) / C1orf125 ()SOAT1 (1q25.2) / RRAGD (6q15)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SOAT1   11177
Cards
Entrez_Gene (NCBI)SOAT1  6646  sterol O-acyltransferase 1
AliasesACACT; ACAT; ACAT-1; ACAT1; 
SOAT; STAT
GeneCards (Weizmann)SOAT1
Ensembl hg19 (Hinxton)ENSG00000057252 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000057252 [Gene_View]  chr1:179293714-179358679 [Contig_View]  SOAT1 [Vega]
ICGC DataPortalENSG00000057252
TCGA cBioPortalSOAT1
AceView (NCBI)SOAT1
Genatlas (Paris)SOAT1
WikiGenes6646
SOURCE (Princeton)SOAT1
Genetics Home Reference (NIH)SOAT1
Genomic and cartography
GoldenPath hg38 (UCSC)SOAT1  -     chr1:179293714-179358679 +  1q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SOAT1  -     1q25.2   [Description]    (hg19-Feb_2009)
EnsemblSOAT1 - 1q25.2 [CytoView hg19]  SOAT1 - 1q25.2 [CytoView hg38]
Mapping of homologs : NCBISOAT1 [Mapview hg19]  SOAT1 [Mapview hg38]
OMIM102642   
Gene and transcription
Genbank (Entrez)AK026611 AK290659 AK294047 AK300551 AK310920
RefSeq transcript (Entrez)NM_001252511 NM_001252512 NM_003101
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SOAT1
Cluster EST : UnigeneHs.445588 [ NCBI ]
CGAP (NCI)Hs.445588
Alternative Splicing GalleryENSG00000057252
Gene ExpressionSOAT1 [ NCBI-GEO ]   SOAT1 [ EBI - ARRAY_EXPRESS ]   SOAT1 [ SEEK ]   SOAT1 [ MEM ]
Gene Expression Viewer (FireBrowse)SOAT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6646
GTEX Portal (Tissue expression)SOAT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35610   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35610  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35610
Splice isoforms : SwissVarP35610
PhosPhoSitePlusP35610
Domains : Interpro (EBI)MBOAT_fam    Oat_ACAT_DAG_ARE    Sterol_acyltranf_meta   
Domain families : Pfam (Sanger)MBOAT (PF03062)   
Domain families : Pfam (NCBI)pfam03062   
Conserved Domain (NCBI)SOAT1
DMDM Disease mutations6646
Blocks (Seattle)SOAT1
SuperfamilyP35610
Human Protein AtlasENSG00000057252
Peptide AtlasP35610
HPRD00033
IPIIPI00745125   IPI01011590   IPI01011123   IPI01012511   IPI00644020   
Protein Interaction databases
DIP (DOE-UCLA)P35610
IntAct (EBI)P35610
FunCoupENSG00000057252
BioGRIDSOAT1
STRING (EMBL)SOAT1
ZODIACSOAT1
Ontologies - Pathways
QuickGOP35610
Ontology : AmiGOfatty-acyl-CoA binding  sterol O-acyltransferase activity  sterol O-acyltransferase activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  receptor-mediated endocytosis  cholesterol metabolic process  cholesterol metabolic process  macrophage derived foam cell differentiation  macrophage derived foam cell differentiation  macrophage derived foam cell differentiation  cholesterol storage  cholesterol binding  membrane  integral component of membrane  cholesterol efflux  very-low-density lipoprotein particle assembly  cholesterol esterification  cholesterol esterification  cholesterol O-acyltransferase activity  cholesterol O-acyltransferase activity  cholesterol O-acyltransferase activity  cholesterol homeostasis  positive regulation of amyloid precursor protein biosynthetic process  
Ontology : EGO-EBIfatty-acyl-CoA binding  sterol O-acyltransferase activity  sterol O-acyltransferase activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  receptor-mediated endocytosis  cholesterol metabolic process  cholesterol metabolic process  macrophage derived foam cell differentiation  macrophage derived foam cell differentiation  macrophage derived foam cell differentiation  cholesterol storage  cholesterol binding  membrane  integral component of membrane  cholesterol efflux  very-low-density lipoprotein particle assembly  cholesterol esterification  cholesterol esterification  cholesterol O-acyltransferase activity  cholesterol O-acyltransferase activity  cholesterol O-acyltransferase activity  cholesterol homeostasis  positive regulation of amyloid precursor protein biosynthetic process  
Pathways : KEGGSteroid biosynthesis   
NDEx NetworkSOAT1
Atlas of Cancer Signalling NetworkSOAT1
Wikipedia pathwaysSOAT1
Orthology - Evolution
OrthoDB6646
GeneTree (enSembl)ENSG00000057252
Phylogenetic Trees/Animal Genes : TreeFamSOAT1
HOVERGENP35610
HOGENOMP35610
Homologs : HomoloGeneSOAT1
Homology/Alignments : Family Browser (UCSC)SOAT1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSOAT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SOAT1
dbVarSOAT1
ClinVarSOAT1
1000_GenomesSOAT1 
Exome Variant ServerSOAT1
ExAC (Exome Aggregation Consortium)SOAT1 (select the gene name)
Genetic variants : HAPMAP6646
Genomic Variants (DGV)SOAT1 [DGVbeta]
DECIPHERSOAT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSOAT1 
Mutations
ICGC Data PortalSOAT1 
TCGA Data PortalSOAT1 
Broad Tumor PortalSOAT1
OASIS PortalSOAT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSOAT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSOAT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SOAT1
DgiDB (Drug Gene Interaction Database)SOAT1
DoCM (Curated mutations)SOAT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SOAT1 (select a term)
intoGenSOAT1
Cancer3DSOAT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM102642   
Orphanet
MedgenSOAT1
Genetic Testing Registry SOAT1
NextProtP35610 [Medical]
TSGene6646
GENETestsSOAT1
Target ValidationSOAT1
Huge Navigator SOAT1 [HugePedia]
snp3D : Map Gene to Disease6646
BioCentury BCIQSOAT1
ClinGenSOAT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6646
Chemical/Pharm GKB GenePA36015
Clinical trialSOAT1
Miscellaneous
canSAR (ICR)SOAT1 (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSOAT1
EVEXSOAT1
GoPubMedSOAT1
iHOPSOAT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:08:08 CEST 2017

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