Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SOCS4 (suppressor of cytokine signaling 4)

Identity

Alias (NCBI)SOCS7
HGNC (Hugo) SOCS4
HGNC Previous nameSOCS7
HGNC Previous namesuppressor of cytokine signaling 7
LocusID (NCBI) 122809
Atlas_Id 51617
Location 14q22.3  [Link to chromosome band 14q22]
Location_base_pair Starts at 55027236 and ends at 55049488 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MTOR (1p36.22) / SOCS4 (14q22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SOCS4   19392
Cards
Entrez_Gene (NCBI)SOCS4    suppressor of cytokine signaling 4
AliasesSOCS7
GeneCards (Weizmann)SOCS4
Ensembl hg19 (Hinxton)ENSG00000180008 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180008 [Gene_View]  ENSG00000180008 [Sequence]  chr14:55027236-55049488 [Contig_View]  SOCS4 [Vega]
ICGC DataPortalENSG00000180008
TCGA cBioPortalSOCS4
AceView (NCBI)SOCS4
Genatlas (Paris)SOCS4
SOURCE (Princeton)SOCS4
Genetics Home Reference (NIH)SOCS4
Genomic and cartography
GoldenPath hg38 (UCSC)SOCS4  -     chr14:55027236-55049488 +  14q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SOCS4  -     14q22.3   [Description]    (hg19-Feb_2009)
GoldenPathSOCS4 - 14q22.3 [CytoView hg19]  SOCS4 - 14q22.3 [CytoView hg38]
ImmunoBaseENSG00000180008
genome Data Viewer NCBISOCS4 [Mapview hg19]  
OMIM616337   
Gene and transcription
Genbank (Entrez)AF424815 AK056685 AK124083 AK126195 AK127299
RefSeq transcript (Entrez)NM_080867 NM_199421
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SOCS4
Alternative Splicing GalleryENSG00000180008
Gene ExpressionSOCS4 [ NCBI-GEO ]   SOCS4 [ EBI - ARRAY_EXPRESS ]   SOCS4 [ SEEK ]   SOCS4 [ MEM ]
Gene Expression Viewer (FireBrowse)SOCS4 [ Firebrowse - Broad ]
GenevisibleExpression of SOCS4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)122809
GTEX Portal (Tissue expression)SOCS4
Human Protein AtlasENSG00000180008-SOCS4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WXH5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WXH5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WXH5
Splice isoforms : SwissVarQ8WXH5
PhosPhoSitePlusQ8WXH5
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SOCS (PS50225)   
Domains : Interpro (EBI)SH2    SH2_dom_sf    SOCS4    SOCS4/SOCS5_dom    SOCS4_SH2    SOCS4_SOCS    SOCS_box    SOCS_box-like_dom_sf   
Domain families : Pfam (Sanger)SH2 (PF00017)    SOCS (PF12610)    SOCS_box (PF07525)   
Domain families : Pfam (NCBI)pfam00017    pfam12610    pfam07525   
Domain families : Smart (EMBL)SH2 (SM00252)  SOCS (SM00253)  SOCS_box (SM00969)  
Conserved Domain (NCBI)SOCS4
Blocks (Seattle)SOCS4
PDB (RSDB)2IZV   
PDB Europe2IZV   
PDB (PDBSum)2IZV   
PDB (IMB)2IZV   
Structural Biology KnowledgeBase2IZV   
SCOP (Structural Classification of Proteins)2IZV   
CATH (Classification of proteins structures)2IZV   
SuperfamilyQ8WXH5
Human Protein Atlas [tissue]ENSG00000180008-SOCS4 [tissue]
Peptide AtlasQ8WXH5
HPRD18084
IPIIPI00103544   
Protein Interaction databases
DIP (DOE-UCLA)Q8WXH5
IntAct (EBI)Q8WXH5
BioGRIDSOCS4
STRING (EMBL)SOCS4
ZODIACSOCS4
Ontologies - Pathways
QuickGOQ8WXH5
Ontology : AmiGOprotein binding  phosphatidylinositol 3-kinase complex  negative regulation of epidermal growth factor-activated receptor activity  protein ubiquitination  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  intracellular signal transduction  regulation of growth  regulation of phosphatidylinositol 3-kinase activity  phosphatidylinositol phosphorylation  1-phosphatidylinositol-3-kinase regulator activity  
Ontology : EGO-EBIprotein binding  phosphatidylinositol 3-kinase complex  negative regulation of epidermal growth factor-activated receptor activity  protein ubiquitination  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  intracellular signal transduction  regulation of growth  regulation of phosphatidylinositol 3-kinase activity  phosphatidylinositol phosphorylation  1-phosphatidylinositol-3-kinase regulator activity  
Pathways : KEGGJak-STAT signaling pathway    Insulin signaling pathway    Prolactin signaling pathway    Type II diabetes mellitus   
NDEx NetworkSOCS4
Atlas of Cancer Signalling NetworkSOCS4
Wikipedia pathwaysSOCS4
Orthology - Evolution
OrthoDB122809
GeneTree (enSembl)ENSG00000180008
Phylogenetic Trees/Animal Genes : TreeFamSOCS4
HOGENOMQ8WXH5
Homologs : HomoloGeneSOCS4
Homology/Alignments : Family Browser (UCSC)SOCS4
Gene fusions - Rearrangements
Fusion : QuiverSOCS4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSOCS4 [hg38]
dbVarSOCS4
ClinVarSOCS4
MonarchSOCS4
1000_GenomesSOCS4 
Exome Variant ServerSOCS4
GNOMAD BrowserENSG00000180008
Varsome BrowserSOCS4
Genomic Variants (DGV)SOCS4 [DGVbeta]
DECIPHERSOCS4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSOCS4 
Mutations
ICGC Data PortalSOCS4 
TCGA Data PortalSOCS4 
Broad Tumor PortalSOCS4
OASIS PortalSOCS4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSOCS4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSOCS4
Mutations and Diseases : HGMDSOCS4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SOCS4
DgiDB (Drug Gene Interaction Database)SOCS4
DoCM (Curated mutations)SOCS4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SOCS4 (select a term)
intoGenSOCS4
Cancer3DSOCS4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616337   
Orphanet
DisGeNETSOCS4
MedgenSOCS4
Genetic Testing Registry SOCS4
NextProtQ8WXH5 [Medical]
GENETestsSOCS4
Target ValidationSOCS4
Huge Navigator SOCS4 [HugePedia]
ClinGenSOCS4
Clinical trials, drugs, therapy
MyCancerGenomeSOCS4
Protein Interactions : CTD
Pharm GKB GenePA164742477
PharosQ8WXH5
Clinical trialSOCS4
Miscellaneous
canSAR (ICR)SOCS4 (select the gene name)
HarmonizomeSOCS4
DataMed IndexSOCS4
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSOCS4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:38:41 CET 2021
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