SOCS4 (suppressor of cytokine signaling 4)

2010-08-01  

Identity

HGNC
LOCATION
14q22.3
LOCUSID
ALIAS
SOCS7
FUSION GENES

Other Information

Locus ID:

NCBI: 122809
MIM: 616337
HGNC: 19392
Ensembl: ENSG00000180008

Variants:

dbSNP: 122809
ClinVar: 122809
TCGA: ENSG00000180008
COSMIC: SOCS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180008ENST00000339298Q8WXH5
ENSG00000180008ENST00000339298Q5H9R6
ENSG00000180008ENST00000395472Q8WXH5
ENSG00000180008ENST00000395472Q5H9R6
ENSG00000180008ENST00000555846Q8WXH5
ENSG00000180008ENST00000555846Q5H9R6

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Jak-STAT signaling pathwayKEGGko04630
Insulin signaling pathwayKEGGko04910
Type II diabetes mellitusKEGGko04930
Jak-STAT signaling pathwayKEGGhsa04630
Insulin signaling pathwayKEGGhsa04910
Type II diabetes mellitusKEGGhsa04930
ECS complexKEGGhsa_M00388
ECS complexKEGGM00388
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
JAK-STAT signalingKEGGhsa_M00684
JAK-STAT signalingKEGGM00684

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
328195882020Exosome-mediated miR-9-5p promotes proliferation and migration of renal cancer cells both in vitro and in vivo by targeting SOCS4.11
328195882020Exosome-mediated miR-9-5p promotes proliferation and migration of renal cancer cells both in vitro and in vivo by targeting SOCS4.11
312000022019Long noncoding RNA TUSC7 inhibits cell proliferation, migration and invasion by regulating SOCS4 (SOCS5) expression through targeting miR-616 in endometrial carcinoma.12
313984632019Suppressor of cytokine signaling genes in renal transplant receivers: Association with transplant fate.0
312000022019Long noncoding RNA TUSC7 inhibits cell proliferation, migration and invasion by regulating SOCS4 (SOCS5) expression through targeting miR-616 in endometrial carcinoma.12
313984632019Suppressor of cytokine signaling genes in renal transplant receivers: Association with transplant fate.0
287517152017In vitro significance of SOCS-3 and SOCS-4 and potential mechanistic links to wound healing.3
287517152017In vitro significance of SOCS-3 and SOCS-4 and potential mechanistic links to wound healing.3
276354282016Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing.8
276354282016Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing.8
252863862015Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer's disease brains and human microglia.25
256398322015A missense mutation underlies defective SOCS4 function in a family with autoimmunity.2
264374442015Interleukin-23 Facilitates Thyroid Cancer Cell Migration and Invasion by Inhibiting SOCS4 Expression via MicroRNA-25.20
252863862015Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer's disease brains and human microglia.25
256398322015A missense mutation underlies defective SOCS4 function in a family with autoimmunity.2

Citation

Dessen P

SOCS4 (suppressor of cytokine signaling 4)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51617/socs4