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SOCS5 (suppressor of cytokine signaling 5)

Identity

Alias (NCBI)CIS6
CISH6
Cish5
SOCS-5
HGNC (Hugo) SOCS5
HGNC Alias symbKIAA0671
SOCS-5
CIS6
CISH6
Cish5
LocusID (NCBI) 9655
Atlas_Id 52610
Location 2p21  [Link to chromosome band 2p21]
Location_base_pair Starts at 46699295 and ends at 46763128 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SOCS5   16852
Cards
Entrez_Gene (NCBI)SOCS5    suppressor of cytokine signaling 5
AliasesCIS6; CISH6; Cish5; SOCS-5
GeneCards (Weizmann)SOCS5
Ensembl hg19 (Hinxton)ENSG00000171150 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171150 [Gene_View]  ENSG00000171150 [Sequence]  chr2:46699295-46763128 [Contig_View]  SOCS5 [Vega]
ICGC DataPortalENSG00000171150
TCGA cBioPortalSOCS5
AceView (NCBI)SOCS5
Genatlas (Paris)SOCS5
SOURCE (Princeton)SOCS5
Genetics Home Reference (NIH)SOCS5
Genomic and cartography
GoldenPath hg38 (UCSC)SOCS5  -     chr2:46699295-46763128 +  2p21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SOCS5  -     2p21   [Description]    (hg19-Feb_2009)
GoldenPathSOCS5 - 2p21 [CytoView hg19]  SOCS5 - 2p21 [CytoView hg38]
ImmunoBaseENSG00000171150
Genome Data Viewer NCBISOCS5 [Mapview hg19]  
OMIM607094   
Gene and transcription
Genbank (Entrez)AB014571 AF073958 AI433294 AK290194 AK296796
RefSeq transcript (Entrez)NM_014011 NM_144949
Consensus coding sequences : CCDS (NCBI)SOCS5
Gene ExpressionSOCS5 [ NCBI-GEO ]   SOCS5 [ EBI - ARRAY_EXPRESS ]   SOCS5 [ SEEK ]   SOCS5 [ MEM ]
Gene Expression Viewer (FireBrowse)SOCS5 [ Firebrowse - Broad ]
GenevisibleExpression of SOCS5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9655
GTEX Portal (Tissue expression)SOCS5
Human Protein AtlasENSG00000171150-SOCS5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75159   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75159  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75159
PhosPhoSitePlusO75159
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SOCS (PS50225)   
Domains : Interpro (EBI)SH2    SH2_dom_sf    SOCS4/SOCS5_dom    SOCS5    SOCS5_SOCS    SOCS_box    SOCS_box-like_dom_sf   
Domain families : Pfam (Sanger)SH2 (PF00017)    SOCS (PF12610)    SOCS_box (PF07525)   
Domain families : Pfam (NCBI)pfam00017    pfam12610    pfam07525   
Domain families : Smart (EMBL)SH2 (SM00252)  SOCS (SM00253)  SOCS_box (SM00969)  
Conserved Domain (NCBI)SOCS5
SuperfamilyO75159
AlphaFold pdb e-kbO75159   
Human Protein Atlas [tissue]ENSG00000171150-SOCS5 [tissue]
HPRD06159
Protein Interaction databases
DIP (DOE-UCLA)O75159
IntAct (EBI)O75159
BioGRIDSOCS5
STRING (EMBL)SOCS5
ZODIACSOCS5
Ontologies - Pathways
QuickGOO75159
Ontology : AmiGOepidermal growth factor receptor binding  protein binding  cytosol  phosphatidylinositol 3-kinase complex  epidermal growth factor receptor signaling pathway  negative regulation of epidermal growth factor-activated receptor activity  receptor signaling pathway via JAK-STAT  negative regulation of signal transduction  protein ubiquitination  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  receptor tyrosine kinase binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  negative regulation of interleukin-6 production  intracellular signal transduction  regulation of growth  regulation of phosphatidylinositol 3-kinase activity  post-translational protein modification  positive regulation of T-helper 1 cell differentiation  negative regulation of T-helper 2 cell differentiation  phosphatidylinositol phosphate biosynthetic process  1-phosphatidylinositol-3-kinase regulator activity  negative regulation of inflammatory response  cellular response to low-density lipoprotein particle stimulus  negative regulation of monocyte chemotactic protein-1 production  vascular endothelial cell response to fluid shear stress  
Ontology : EGO-EBIepidermal growth factor receptor binding  protein binding  cytosol  phosphatidylinositol 3-kinase complex  epidermal growth factor receptor signaling pathway  negative regulation of epidermal growth factor-activated receptor activity  receptor signaling pathway via JAK-STAT  negative regulation of signal transduction  protein ubiquitination  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  receptor tyrosine kinase binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  negative regulation of interleukin-6 production  intracellular signal transduction  regulation of growth  regulation of phosphatidylinositol 3-kinase activity  post-translational protein modification  positive regulation of T-helper 1 cell differentiation  negative regulation of T-helper 2 cell differentiation  phosphatidylinositol phosphate biosynthetic process  1-phosphatidylinositol-3-kinase regulator activity  negative regulation of inflammatory response  cellular response to low-density lipoprotein particle stimulus  negative regulation of monocyte chemotactic protein-1 production  vascular endothelial cell response to fluid shear stress  
Pathways : KEGGJak-STAT signaling pathway    Prolactin signaling pathway   
NDEx NetworkSOCS5
Atlas of Cancer Signalling NetworkSOCS5
Wikipedia pathwaysSOCS5
Orthology - Evolution
OrthoDB9655
GeneTree (enSembl)ENSG00000171150
Phylogenetic Trees/Animal Genes : TreeFamSOCS5
Homologs : HomoloGeneSOCS5
Homology/Alignments : Family Browser (UCSC)SOCS5
Gene fusions - Rearrangements
Fusion : QuiverSOCS5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSOCS5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SOCS5
dbVarSOCS5
ClinVarSOCS5
MonarchSOCS5
1000_GenomesSOCS5 
Exome Variant ServerSOCS5
GNOMAD BrowserENSG00000171150
Varsome BrowserSOCS5
ACMGSOCS5 variants
VarityO75159
Genomic Variants (DGV)SOCS5 [DGVbeta]
DECIPHERSOCS5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSOCS5 
Mutations
ICGC Data PortalSOCS5 
TCGA Data PortalSOCS5 
Broad Tumor PortalSOCS5
OASIS PortalSOCS5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSOCS5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSOCS5
Mutations and Diseases : HGMDSOCS5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSOCS5
DgiDB (Drug Gene Interaction Database)SOCS5
DoCM (Curated mutations)SOCS5
CIViC (Clinical Interpretations of Variants in Cancer)SOCS5
Cancer3DSOCS5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607094   
Orphanet
DisGeNETSOCS5
MedgenSOCS5
Genetic Testing Registry SOCS5
NextProtO75159 [Medical]
GENETestsSOCS5
Target ValidationSOCS5
Huge Navigator SOCS5 [HugePedia]
ClinGenSOCS5
Clinical trials, drugs, therapy
MyCancerGenomeSOCS5
Protein Interactions : CTDSOCS5
Pharm GKB GenePA134884627
PharosO75159
Clinical trialSOCS5
Miscellaneous
canSAR (ICR)SOCS5
HarmonizomeSOCS5
DataMed IndexSOCS5
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSOCS5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:32:35 CEST 2021

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