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SOCS5 (suppressor of cytokine signaling 5)

Identity

Alias_symbol (synonym)KIAA0671
SOCS-5
CIS6
CISH6
Cish5
Other alias
HGNC (Hugo) SOCS5
LocusID (NCBI) 9655
Atlas_Id 52610
Location 2p21  [Link to chromosome band 2p21]
Location_base_pair Starts at 46698960 and ends at 46762788 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SOCS5   16852
Cards
Entrez_Gene (NCBI)SOCS5  9655  suppressor of cytokine signaling 5
AliasesCIS6; CISH6; Cish5; SOCS-5
GeneCards (Weizmann)SOCS5
Ensembl hg19 (Hinxton)ENSG00000171150 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171150 [Gene_View]  chr2:46698960-46762788 [Contig_View]  SOCS5 [Vega]
ICGC DataPortalENSG00000171150
TCGA cBioPortalSOCS5
AceView (NCBI)SOCS5
Genatlas (Paris)SOCS5
WikiGenes9655
SOURCE (Princeton)SOCS5
Genetics Home Reference (NIH)SOCS5
Genomic and cartography
GoldenPath hg38 (UCSC)SOCS5  -     chr2:46698960-46762788 +  2p21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SOCS5  -     2p21   [Description]    (hg19-Feb_2009)
EnsemblSOCS5 - 2p21 [CytoView hg19]  SOCS5 - 2p21 [CytoView hg38]
Mapping of homologs : NCBISOCS5 [Mapview hg19]  SOCS5 [Mapview hg38]
OMIM607094   
Gene and transcription
Genbank (Entrez)AB014571 AF073958 AI433294 AK290194 AK296796
RefSeq transcript (Entrez)NM_014011 NM_144949
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SOCS5
Cluster EST : UnigeneHs.468426 [ NCBI ]
CGAP (NCI)Hs.468426
Alternative Splicing GalleryENSG00000171150
Gene ExpressionSOCS5 [ NCBI-GEO ]   SOCS5 [ EBI - ARRAY_EXPRESS ]   SOCS5 [ SEEK ]   SOCS5 [ MEM ]
Gene Expression Viewer (FireBrowse)SOCS5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9655
GTEX Portal (Tissue expression)SOCS5
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75159   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75159  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75159
Splice isoforms : SwissVarO75159
PhosPhoSitePlusO75159
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SOCS (PS50225)   
Domains : Interpro (EBI)SH2    SOCS4/SOCS5_dom    SOCS5    SOCS_box   
Domain families : Pfam (Sanger)SH2 (PF00017)    SOCS (PF12610)    SOCS_box (PF07525)   
Domain families : Pfam (NCBI)pfam00017    pfam12610    pfam07525   
Domain families : Smart (EMBL)SH2 (SM00252)  SOCS (SM00253)  SOCS_box (SM00969)  
Conserved Domain (NCBI)SOCS5
DMDM Disease mutations9655
Blocks (Seattle)SOCS5
SuperfamilyO75159
Human Protein AtlasENSG00000171150
Peptide AtlasO75159
HPRD06159
IPIIPI00022271   
Protein Interaction databases
DIP (DOE-UCLA)O75159
IntAct (EBI)O75159
FunCoupENSG00000171150
BioGRIDSOCS5
STRING (EMBL)SOCS5
ZODIACSOCS5
Ontologies - Pathways
QuickGOO75159
Ontology : AmiGOprotein kinase inhibitor activity  epidermal growth factor receptor binding  protein binding  cytoplasm  cytosol  epidermal growth factor receptor signaling pathway  negative regulation of epidermal growth factor-activated receptor activity  JAK-STAT cascade  negative regulation of signal transduction  cell growth  protein ubiquitination  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  receptor tyrosine kinase binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  negative regulation of interleukin-6 production  regulation of growth  positive regulation of T-helper 1 cell differentiation  negative regulation of T-helper 2 cell differentiation  negative regulation of JAK-STAT cascade  negative regulation of inflammatory response  cellular response to low-density lipoprotein particle stimulus  negative regulation of monocyte chemotactic protein-1 production  vascular endothelial cell response to fluid shear stress  
Ontology : EGO-EBIprotein kinase inhibitor activity  epidermal growth factor receptor binding  protein binding  cytoplasm  cytosol  epidermal growth factor receptor signaling pathway  negative regulation of epidermal growth factor-activated receptor activity  JAK-STAT cascade  negative regulation of signal transduction  cell growth  protein ubiquitination  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  receptor tyrosine kinase binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  negative regulation of interleukin-6 production  regulation of growth  positive regulation of T-helper 1 cell differentiation  negative regulation of T-helper 2 cell differentiation  negative regulation of JAK-STAT cascade  negative regulation of inflammatory response  cellular response to low-density lipoprotein particle stimulus  negative regulation of monocyte chemotactic protein-1 production  vascular endothelial cell response to fluid shear stress  
Pathways : KEGGJak-STAT signaling pathway    Prolactin signaling pathway   
NDEx NetworkSOCS5
Atlas of Cancer Signalling NetworkSOCS5
Wikipedia pathwaysSOCS5
Orthology - Evolution
OrthoDB9655
GeneTree (enSembl)ENSG00000171150
Phylogenetic Trees/Animal Genes : TreeFamSOCS5
HOVERGENO75159
HOGENOMO75159
Homologs : HomoloGeneSOCS5
Homology/Alignments : Family Browser (UCSC)SOCS5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSOCS5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SOCS5
dbVarSOCS5
ClinVarSOCS5
1000_GenomesSOCS5 
Exome Variant ServerSOCS5
ExAC (Exome Aggregation Consortium)SOCS5 (select the gene name)
Genetic variants : HAPMAP9655
Genomic Variants (DGV)SOCS5 [DGVbeta]
DECIPHERSOCS5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSOCS5 
Mutations
ICGC Data PortalSOCS5 
TCGA Data PortalSOCS5 
Broad Tumor PortalSOCS5
OASIS PortalSOCS5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSOCS5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSOCS5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SOCS5
DgiDB (Drug Gene Interaction Database)SOCS5
DoCM (Curated mutations)SOCS5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SOCS5 (select a term)
intoGenSOCS5
Cancer3DSOCS5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607094   
Orphanet
MedgenSOCS5
Genetic Testing Registry SOCS5
NextProtO75159 [Medical]
TSGene9655
GENETestsSOCS5
Target ValidationSOCS5
Huge Navigator SOCS5 [HugePedia]
snp3D : Map Gene to Disease9655
BioCentury BCIQSOCS5
ClinGenSOCS5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9655
Chemical/Pharm GKB GenePA134884627
Clinical trialSOCS5
Miscellaneous
canSAR (ICR)SOCS5 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSOCS5
EVEXSOCS5
GoPubMedSOCS5
iHOPSOCS5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:15:19 CEST 2017

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